AIMC Topic: Mice, Knockout

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MASP-2 deficiency does not prevent the progression of diabetic kidney disease in a mouse model of type 1 diabetes.

Scandinavian journal of immunology Dec 25, 2023
Mannan-binding lectin (MBL) initiates the lectin pathway of complement and has been linked to albuminuria and mortality in diabetes. We hypothesize that MBL-associated serine protease 2 (MASP-2) deficiency will protect against diabetes-induced kidney...
Mannose-Binding Protein-Associated Serine Proteases Diabetic Nephropathies Animals Diabetes Mellitus, Type 1 Mice, Knockout Disease Models, Animal Male Albuminuria Cystatin C Mice, Inbred C57BL Disease Progression Mice Diabetes Mellitus, Experimental
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Structural, functional and molecular pathogenesis of pelvic organ prolapse in patient and deficient mice.

Aging Dec 19, 2021
Pelvic organ prolapse is a worldwide health problem to elderly women. Understanding its pathogenesis and an ideal animal model are crucial to developing promising treatments. The present study aimed to investigate new clinical significance and detail...
Female Aged Aged, 80 and over Animals Humans Middle Aged Mice Disease Models, Animal Mice, Inbred C57BL Gene Ontology Pelvic Organ Prolapse Amino Acid Oxidoreductases Mice, Knockout Collagen
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Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease.

Nature communications Jul 12, 2021
Modeling human diseases as networks simplify complex multi-cellular processes, helps understand patterns in noisy data that humans cannot find, and thereby improves precision in prediction. Using Inflammatory Bowel Disease (IBD) as an example, here w...
Humans Dextran Sulfate Colitis Organoids Disease Models, Animal Gene Expression Regulation Animals Mice, Inbred C57BL AMP-Activated Protein Kinases Molecular Targeted Therapy Multigene Family Cohort Studies Intestinal Mucosa Likelihood Functions Mice Mice, Knockout Artificial Intelligence Treatment Outcome Machine Learning Inflammatory Bowel Diseases Reproducibility of Results
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Enhanced Integrated Gradients: improving interpretability of deep learning models using splicing codes as a case study.

Genome biology Jun 19, 2020
Despite the success and fast adaptation of deep learning models in biomedical domains, their lack of interpretability remains an issue. Here, we introduce Enhanced Integrated Gradients (EIG), a method to identify significant features associated with ...
Computational Biology Liver Mice, Knockout RNA Splicing Animals Deep Learning
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Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature.

eLife May 14, 2020
The transcriptional activation and repression during NK cell ontology are poorly understood. Here, using single-cell RNA-sequencing, we reveal a novel role for T-bet in suppressing the immature gene signature during murine NK cell development. Based ...
Forkhead Box Protein O1 Mechanistic Target of Rapamycin Complex 2 Rapamycin-Insensitive Companion of mTOR Protein Regulatory-Associated Protein of mTOR Proto-Oncogene Proteins c-akt Bone Marrow Cells Gene Expression Regulation Killer Cells, Natural T-Box Domain Proteins T-bet Transcription Factor Animals Gene Expression Profiling Transcriptome Single-Cell Analysis Cluster Analysis Mice, Inbred C57BL Mice, Knockout RNA-Seq Genotype Machine Learning Phenotype
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Machine learning predicts putative hematopoietic stem cells within large single-cell transcriptomics data sets.

Experimental hematology Sep 9, 2019
Hematopoietic stem cells (HSCs) are an essential source and reservoir for normal hematopoiesis, and their function is compromised in many blood disorders. HSC research has benefitted from the recent development of single-cell molecular profiling tech...
Mice, Knockout Hematopoietic Stem Cells Gene Expression Profiling Transcriptome Mice Sequence Analysis, RNA Machine Learning Animals
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Detection and Classification of Novel Renal Histologic Phenotypes Using Deep Neural Networks.

The American journal of pathology Jun 18, 2019
With the advent and increased accessibility of deep neural networks (DNNs), complex properties of histologic images can be rigorously and reproducibly quantified. We used DNN-based transfer learning to analyze histologic images of periodic acid-Schif...
Male Image Processing, Computer-Assisted Mice Kidney Neural Networks, Computer Mice, Knockout Aldehyde Oxidoreductases Phenotype Neural Pathways Animals
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Real-time analysis of the behaviour of groups of mice via a depth-sensing camera and machine learning.

Nature biomedical engineering May 20, 2019
Preclinical studies of psychiatric disorders use animal models to investigate the impact of environmental factors or genetic mutations on complex traits such as decision-making and social interactions. Here, we introduce a method for the real-time an...
Female Animals Male Mice Mice, Knockout Mutation Video Recording Machine Learning Disease Models, Animal Phenotype Nerve Tissue Proteins Microfilament Proteins Autistic Disorder Behavior, Animal Behavioral Research Social Behavior
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Refining humane endpoints in mouse models of disease by systematic review and machine learning-based endpoint definition.

ALTEX Apr 18, 2019
Ideally, humane endpoints allow for early termination of experiments by minimizing an animal's discomfort, distress and pain, while ensuring that scientific objectives are reached. Yet, lack of commonly agreed methodology and heterogeneity of cut-off...
Female Body Temperature Animals Ethical Review Male Body Weight Supervised Machine Learning Animal Welfare Random Allocation Disease Models, Animal Severity of Illness Index Mice, Inbred C57BL Sepsis Mice, Knockout Time Factors Systematic Reviews as Topic Mice Stroke
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Morphometric analysis of peripheral myelinated nerve fibers through deep learning.

Journal of the peripheral nervous system : JPNS Dec 11, 2018
Irrespective of initial causes of neurological diseases, these disorders usually exhibit two key pathological changes-axonal loss or demyelination or a mixture of the two. Therefore, vigorous quantification of myelin and axons is essential in studyin...
Nerve Fibers, Myelinated Deep Learning Mice Mice, Knockout Mice, Inbred C57BL Microscopy Animals Axons Pattern Recognition, Automated
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