AIMC Topic: Mice, Knockout

Clear Filters Showing 21 to 28 of 28 articles

Deep learning-based quantification of abdominal fat on magnetic resonance images.

PloS one Sep 20, 2018
Obesity is increasingly prevalent and associated with increased risk of developing type 2 diabetes, cardiovascular diseases, and cancer. Magnetic resonance imaging (MRI) is an accurate method for determination of body fat volume and distribution. How...
Apolipoproteins E Subcutaneous Fat Diet, Western Mice, Inbred C3H Automation Organ Specificity Abdominal Fat Intra-Abdominal Fat Female Animals Male Deep Learning Adipose Tissue Mice, Knockout Body Weight Magnetic Resonance Imaging Mice, Inbred C57BL Phenotype
View on PubMed DOI

TIGERi: modeling and visualizing the responses to perturbation of a transcription factor network.

BMC bioinformatics May 31, 2017
BACKGROUND: Transcription factor (TF) networks play a key role in controlling the transfer of genetic information from gene to mRNA. Much progress has been made on understanding and reverse-engineering TF network topologies using a range of experimen...
Mice Transcription Factors Mice, Knockout Binding Sites Mitogen-Activated Protein Kinase 14 Machine Learning Animals Transcriptome Gene Regulatory Networks
View on PubMed DOI

and cell-based analyses reveal strong divergence between prediction and observation of T-cell-recognized tumor antigen T-cell epitopes.

The Journal of biological chemistry May 23, 2017
Tumor exomes provide comprehensive information on mutated, overexpressed genes and aberrant splicing, which can be exploited for personalized cancer immunotherapy. Of particular interest are mutated tumor antigen T-cell epitopes, because neoepitope-s...
Antigens, Neoplasm Vaccines, Synthetic Membrane Proteins Neoplasm Proteins Epitopes HLA-A2 Antigen Protein Stability Mice, Knockout Peptide Fragments Reproducibility of Results Animals Computational Biology Cancer Vaccines Humans Artificial Intelligence Cells, Cultured Melanoma Models, Immunological Protein Refolding T-Lymphocytes, Cytotoxic Expert Systems Oligopeptides Immunogenicity, Vaccine Mice, Transgenic
View on PubMed DOI

Adaptations to excess choline in insulin resistant and Pcyt2 deficient skeletal muscle.

Biochemistry and cell biology = Biochimie et biologie cellulaire Sep 6, 2016
It was hypothesized that choline supplementation in insulin resistant (IR) CTP:phosphoethanolamine cytidylyltransferase deficient (Pcyt2) mice would ameliorate muscle function by remodeling glucose and fatty acid (FA) metabolism. Pcyt2 mice either re...
Organic Cation Transport Proteins RNA Nucleotidyltransferases Sterol Regulatory Element Binding Protein 1 fas Receptor Adaptation, Physiological Carnitine O-Palmitoyltransferase Diacylglycerol O-Acyltransferase Insulin Receptor Substrate Proteins Administration, Oral Choline Gene Expression Regulation PPAR alpha Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Stearoyl-CoA Desaturase Lipogenesis Triglycerides Microtubule-Associated Proteins Muscle, Skeletal Mice, Knockout Glucose Fatty Acids Animals Mice Insulin Resistance Signal Transduction
View on PubMed DOI

Dissecting cross-lineage tumourigenesis under p53 inactivation through single-cell multi-omics and spatial transcriptomics.

Clinical and translational medicine Sep 1, 2025
BACKGROUND: Tumour suppressor genes, exemplified by TP53 (encoding the human p53), function as critical guardians against tumourigenesis. Germline TP53-inactivating mutations underlie Li-Fraumeni syndrome, a hereditary cancer predisposition disorder ...
Humans Multiomics Carcinogenesis Mice, Knockout Tumor Suppressor Protein p53 Li-Fraumeni Syndrome Animals Transcriptome Single-Cell Analysis Mice
View on PubMed DOI

Tribulus terrestris L. Extract Alleviates Atherosclerosis by Suppressing TNF-α-Mediated Macrophage Inflammation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology Aug 15, 2025
Atherosclerosis (AS) is a major contributor to cardiovascular disease. In traditional Chinese medicine, Tribulus terrestris L., or Baijili (BJL), has shown therapeutic effects on inflammation and cardiovascular issues. Our prior research indicated th...
RAW 264.7 Cells Apolipoproteins E Tribulus Mice, Inbred C57BL Diet, High-Fat Mice, Knockout Atherosclerosis Tumor Necrosis Factor-alpha Macrophages Animals Mice Plant Extracts Inflammation Male Molecular Docking Simulation
View on PubMed DOI

AI Quantification of Vascular Lesions in Mouse Fundus Fluorescein Angiography.

Translational vision science & technology Jun 2, 2025
PURPOSE: Quantifying vascular leakage in fundus fluorescein angiography (FFA) is a critical endpoint in preclinical models of diseases such as neovascular age-related macular degeneration, retinopathy of prematurity, and diabetic retinopathy. Traditi...
Artificial Intelligence Animals Choroidal Neovascularization Image Processing, Computer-Assisted Mice Disease Models, Animal Mice, Knockout Fundus Oculi Fluorescein Angiography Retinal Neovascularization Retinal Vessels
View on PubMed DOI

Network Tomography for Understanding Phenotypic Presentations in Aortic Stenosis.

JACC. Cardiovascular imaging Feb 1, 2019
OBJECTIVES: This study sought to build a patient-patient similarity network using multiple features of left ventricular (LV) structure and function in patients with aortic stenosis (AS). The study further validated the observations in an experimental...
Severity of Illness Index Time Factors Disease Models, Animal Aortic Valve Stenosis Ventricular Function, Left Echocardiography Middle Aged Disease Progression Image Interpretation, Computer-Assisted Heart Valve Prosthesis Implantation Balloon Valvuloplasty Aortic Valve Predictive Value of Tests Mice, Knockout Heart Ventricles Humans Machine Learning Female Reproducibility of Results Cross-Sectional Studies Animals Male Aged Aged, 80 and over
View on PubMed DOI
Popular Topics
Recent Journals