AIMC Topic: Mice, Knockout

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Adaptations to excess choline in insulin resistant and Pcyt2 deficient skeletal muscle.

Biochemistry and cell biology = Biochimie et biologie cellulaire Sep 6, 2016
It was hypothesized that choline supplementation in insulin resistant (IR) CTP:phosphoethanolamine cytidylyltransferase deficient (Pcyt2) mice would ameliorate muscle function by remodeling glucose and fatty acid (FA) metabolism. Pcyt2 mice either re...
Muscle, Skeletal Stearoyl-CoA Desaturase PPAR alpha Lipogenesis Triglycerides Mice, Knockout Adaptation, Physiological Choline Insulin Resistance Microtubule-Associated Proteins Gene Expression Regulation Animals Fatty Acids Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Signal Transduction Mice Glucose Administration, Oral RNA Nucleotidyltransferases Sterol Regulatory Element Binding Protein 1 fas Receptor Carnitine O-Palmitoyltransferase Diacylglycerol O-Acyltransferase Insulin Receptor Substrate Proteins Organic Cation Transport Proteins
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Tribulus terrestris L. Extract Alleviates Atherosclerosis by Suppressing TNF-α-Mediated Macrophage Inflammation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology Aug 15, 2025
Atherosclerosis (AS) is a major contributor to cardiovascular disease. In traditional Chinese medicine, Tribulus terrestris L., or Baijili (BJL), has shown therapeutic effects on inflammation and cardiovascular issues. Our prior research indicated th...
Inflammation Mice, Inbred C57BL Diet, High-Fat Mice RAW 264.7 Cells Tumor Necrosis Factor-alpha Mice, Knockout Apolipoproteins E Plant Extracts Atherosclerosis Tribulus Macrophages Animals Male Molecular Docking Simulation
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AI Quantification of Vascular Lesions in Mouse Fundus Fluorescein Angiography.

Translational vision science & technology Jun 2, 2025
PURPOSE: Quantifying vascular leakage in fundus fluorescein angiography (FFA) is a critical endpoint in preclinical models of diseases such as neovascular age-related macular degeneration, retinopathy of prematurity, and diabetic retinopathy. Traditi...
Artificial Intelligence Animals Disease Models, Animal Mice, Knockout Fundus Oculi Image Processing, Computer-Assisted Mice Retinal Vessels Choroidal Neovascularization Fluorescein Angiography Retinal Neovascularization
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Network Tomography for Understanding Phenotypic Presentations in Aortic Stenosis.

JACC. Cardiovascular imaging Feb 1, 2019
OBJECTIVES: This study sought to build a patient-patient similarity network using multiple features of left ventricular (LV) structure and function in patients with aortic stenosis (AS). The study further validated the observations in an experimental...
Balloon Valvuloplasty Image Interpretation, Computer-Assisted Heart Valve Prosthesis Implantation Aortic Valve Stenosis Aortic Valve Mice, Knockout Heart Ventricles Predictive Value of Tests Time Factors Disease Models, Animal Disease Progression Severity of Illness Index Humans Machine Learning Animals Male Echocardiography Ventricular Function, Left Aged Middle Aged Female Aged, 80 and over Reproducibility of Results Cross-Sectional Studies
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