AIMC Topic: Mice

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A computational framework for optimal control of a self-adjustive neural system with activity-dependent and homeostatic plasticity.

NeuroImage
The control of the brain system has received increasing attention in the domain of brain science. Most brain control studies have been conducted to explore the brain network's graph-theoretic properties or to produce the desired state based on neural...

DeepLabStream enables closed-loop behavioral experiments using deep learning-based markerless, real-time posture detection.

Communications biology
In general, animal behavior can be described as the neuronal-driven sequence of reoccurring postures through time. Most of the available current technologies focus on offline pose estimation with high spatiotemporal resolution. However, to correlate ...

Machine learning approaches reveal subtle differences in breathing and sleep fragmentation in -derived astrocytes ablated mice.

Journal of neurophysiology
Modern neurophysiology research requires the interrogation of high-dimensionality data sets. Machine learning and artificial intelligence (ML/AI) workflows have permeated into nearly all aspects of daily life in the developed world but have not been ...

Integrated functional neuronal network analysis of 3D silk-collagen scaffold-based mouse cortical culture.

STAR protocols
Bioengineered 3D tunable neuronal constructs are a versatile platform for studying neuronal network functions, offering numerous advantages over existing technologies and providing for the discovery of new biological insights. Functional neural netwo...

Manipulation of Single Neural Stem Cells and Neurons in Brain Slices using Robotic Microinjection.

Journal of visualized experiments : JoVE
A central question in developmental neurobiology is how neural stem and progenitor cells form the brain. To answer this question, one needs to label, manipulate, and follow single cells in the brain tissue with high resolution over time. This task is...

Automatic classification of mice vocalizations using Machine Learning techniques and Convolutional Neural Networks.

PloS one
Ultrasonic vocalizations (USVs) analysis is a well-recognized tool to investigate animal communication. It can be used for behavioral phenotyping of murine models of different disorders. The USVs are usually recorded with a microphone sensitive to ul...

DeepLPI: a multimodal deep learning method for predicting the interactions between lncRNAs and protein isoforms.

BMC bioinformatics
BACKGROUND: Long non-coding RNAs (lncRNAs) regulate diverse biological processes via interactions with proteins. Since the experimental methods to identify these interactions are expensive and time-consuming, many computational methods have been prop...

Bi-channel image registration and deep-learning segmentation (BIRDS) for efficient, versatile 3D mapping of mouse brain.

eLife
We have developed an open-source software called bi-channel image registration and deep-learning segmentation (BIRDS) for the mapping and analysis of 3D microscopy data and applied this to the mouse brain. The BIRDS pipeline includes image preprocess...

Automated joint skull-stripping and segmentation with Multi-Task U-Net in large mouse brain MRI databases.

NeuroImage
Skull-stripping and region segmentation are fundamental steps in preclinical magnetic resonance imaging (MRI) studies, and these common procedures are usually performed manually. We present Multi-task U-Net (MU-Net), a convolutional neural network de...

Automated Extraction of Skin Wound Healing Biomarkers From In Vivo Label-Free Multiphoton Microscopy Using Convolutional Neural Networks.

Lasers in surgery and medicine
BACKGROUND AND OBJECTIVES: Histological analysis is a gold standard technique for studying impaired skin wound healing. Label-free multiphoton microscopy (MPM) can provide natural image contrast similar to histological sections and quantitative metab...