AIMC Topic: Molecular Diagnostic Techniques

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Strategies for Testing Intervention Matching Schemes in Cancer.

Clinical pharmacology and therapeutics Jul 24, 2020
Personalized medicine, or the tailoring of health interventions to an individual's nuanced and often unique genetic, biochemical, physiological, behavioral, and/or exposure profile, is seen by many as a biological necessity given the great heterogene...
Humans Artificial Intelligence Decision Support Techniques Antineoplastic Agents Molecular Diagnostic Techniques Models, Theoretical Predictive Value of Tests Molecular Targeted Therapy Precision Medicine Clinical Decision-Making Biomarkers, Tumor Neoplasms
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Deep Learning Predicts Molecular Subtype of Muscle-invasive Bladder Cancer from Conventional Histopathological Slides.

European urology Apr 27, 2020
BACKGROUND: Muscle-invasive bladder cancer (MIBC) is the second most common genitourinary malignancy, and is associated with high morbidity and mortality. Recently, molecular subtypes of MIBC have been identified, which have important clinical implic...
Neoplasm Invasiveness Humans Forecasting Deep Learning Molecular Diagnostic Techniques Urinary Bladder Neoplasms
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A quite sensitive fluorescent loop-mediated isothermal amplification for rapid detection of respiratory syncytial virus.

Journal of infection in developing countries Dec 31, 2019
INTRODUCTION: Human respiratory syncytial virus (hRSV) is a common respiratory virus closely related to respiratory tract infection (RTI). Rapid and accurate detection of hRSV is urgently needed to reduce the high morbidity and mortality due to hRSV ...
Respiratory Syncytial Virus, Human Child, Preschool Humans Molecular Diagnostic Techniques Respiratory Tract Infections Nucleic Acid Amplification Techniques Sensitivity and Specificity Reverse Transcription Respiratory Syncytial Virus Infections Infant China
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A colorimetric Loop-mediated isothermal amplification (LAMP) assay based on HRP-mimicking molecular beacon for the rapid detection of Vibrio parahaemolyticus.

Biosensors & bioelectronics Dec 16, 2019
In the world wide, food poisoning accidents related to Vibrio spp. are on the rise, even numbers of food poisoning by other foodborne pathogens are decreasing. Therefore, the requirement of the rapid, sensitive and convenient detection method for V. ...
Limit of Detection Seafood Vibrio Infections Food Microbiology Nucleic Acid Amplification Techniques Foodborne Diseases Colorimetry Humans Biosensing Techniques Molecular Diagnostic Techniques Vibrio parahaemolyticus
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An interpretation algorithm for molecular diagnosis of bacterial vaginosis in a maternity hospital using machine learning: proof-of-concept study.

Diagnostic microbiology and infectious disease Nov 27, 2019
Allplex Bacterial vaginosis assay (Seegene, South Korea) is a molecular test for bacterial vaginosis (BV). A machine learning algorithm was devised on 200 samples (BV = 23, non-BV = 177) converting 7 identified bacterial strains polymerase chain reac...
Reproducibility of Results Sensitivity and Specificity Molecular Diagnostic Techniques Hospitals, Maternity Cross Infection Humans Machine Learning Algorithms Female Polymerase Chain Reaction Proof of Concept Study Vaginosis, Bacterial
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Artificial intelligence in clinical and genomic diagnostics.

Genome medicine Nov 19, 2019
Artificial intelligence (AI) is the development of computer systems that are able to perform tasks that normally require human intelligence. Advances in AI software and hardware, especially deep learning algorithms and the graphics processing units (...
Deep Learning Neural Networks, Computer Molecular Diagnostic Techniques Humans Artificial Intelligence Genetics, Medical Genomics Algorithms Molecular Sequence Annotation Genetic Association Studies Phenotype Computational Biology
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Rapid microarray-based assay for detection of pyrazinamide resistant Mycobacterium tuberculosis.

Diagnostic microbiology and infectious disease Dec 30, 2018
Pyrazinamide (PZA) is a key antibiotic for the treatment of drug susceptible tuberculosis. PZA-resistance is mainly mediated by mutations in the pncA gene; however the current gold standard is a phenotypic drug susceptibility test requiring a well-ad...
Humans Eswatini Sensitivity and Specificity Microarray Analysis Pyrazinamide Antitubercular Agents Transition Temperature Tuberculosis, Multidrug-Resistant Time Factors Mycobacterium tuberculosis Genotype Amidohydrolases Molecular Diagnostic Techniques DNA, Bacterial
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A Nasal Brush-based Classifier of Asthma Identified by Machine Learning Analysis of Nasal RNA Sequence Data.

Scientific reports Jun 11, 2018
Asthma is a common, under-diagnosed disease affecting all ages. We sought to identify a nasal brush-based classifier of mild/moderate asthma. 190 subjects with mild/moderate asthma and controls underwent nasal brushing and RNA sequencing of nasal sam...
Molecular Diagnostic Techniques Sequence Analysis, RNA Predictive Value of Tests Nasal Mucosa Asthma Sensitivity and Specificity Male Gene Expression Profiling Humans Machine Learning Prospective Studies Female Young Adult Adult
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A European multicenter study on the analytical performance of the VERIS HBV assay.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology Dec 19, 2017
BACKGROUND: Hepatitis B viral load monitoring is an essential part of managing patients with chronic Hepatits B infection. Beckman Coulter has developed the VERIS HBV Assay for use on the fully automated Beckman Coulter DxN VERIS Molecular Diagnostic...
Real-Time Polymerase Chain Reaction Hepatitis B virus Hepatitis B Genotype Humans Molecular Diagnostic Techniques Automation, Laboratory Europe Sensitivity and Specificity Limit of Detection Viral Load RNA, Viral
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Evaluation of a Urine-Based Rapid Molecular Diagnostic Test with Potential to Be Used at Point-of-Care for Pulmonary Tuberculosis: Cape Town Cohort.

The Journal of molecular diagnostics : JMD Dec 18, 2017
Tuberculosis (TB) diagnosis among sputum-scarce patients is time consuming. Thus, a nonsputum diagnostic alternative is urgently needed. The Mycobacterium tuberculosis-specific transrenal (Tr) DNA from urine is a potential target for TB diagnostics. ...
Polymerase Chain Reaction Multivariate Analysis Microscopy Tuberculosis, Pulmonary Mycobacterium tuberculosis Logistic Models Diagnostic Tests, Routine Sensitivity and Specificity Universities Cross-Sectional Studies Sputum Male South Africa Aged Point-of-Care Systems Cohort Studies Middle Aged Aged, 80 and over Molecular Diagnostic Techniques Humans HIV Infections Young Adult DNA, Bacterial Biomarkers Adult Female Risk Factors
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