AIMC Topic: Neoplasm Proteins

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Classifying the molecular functions of Rab GTPases in membrane trafficking using deep convolutional neural networks.

Analytical biochemistry Jun 13, 2018
Deep learning has been increasingly used to solve a number of problems with state-of-the-art performance in a wide variety of fields. In biology, deep learning can be applied to reduce feature extraction time and achieve high levels of performance. I...
Humans Cell Membrane Protein Transport Intellectual Disability Choroideremia rab GTP-Binding Proteins Neural Networks, Computer Machine Learning Neoplasms Neoplasm Proteins Models, Biological
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Agonists of G-Protein-Coupled Odorant Receptors Are Predicted from Chemical Features.

The journal of physical chemistry letters Apr 17, 2018
Predicting the activity of chemicals for a given odorant receptor is a longstanding challenge. Here the activity of 258 chemicals on the human G-protein-coupled odorant receptor (OR)51E1, also known as prostate-specific G-protein-coupled receptor 2 (...
Drug Evaluation, Preclinical Humans Machine Learning Mice Fatty Acids Animals Receptors, G-Protein-Coupled Ligands Protein Binding Neoplasm Proteins Receptors, Odorant Models, Molecular
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Higher Serum Endocan Level Is Associated with Alzheimer Disease.

Dementia and geriatric cognitive disorders Jan 26, 2018
BACKGROUND: The novel molecule endocan, which is released by endothelium and is regulated by proangiogenic and proinflammatory cytokines, may have a role in the pathophysiology of Alzheimer disease (AD). The aim of this study was to evaluate the rela...
Neoplasm Proteins Geriatric Assessment Aged, 80 and over Neuropsychological Tests Reference Values Humans Male Alzheimer Disease Biomarkers Cognitive Dysfunction Female ROC Curve Aged Proteoglycans
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PSCA rs1045531 Polymorphism and the Risk of Prostate Cancer in a Chinese Population Undergoing Prostate Biopsy.

Technology in cancer research & treatment Nov 14, 2017
BACKGROUND AND PURPOSE: This study explored the association between a single-nucleotide polymorphism of prostate stem cell antigen and prostate cancer in Chinese patients undergoing prostate biopsy.
Genetic Association Studies Antigens, Neoplasm Neoplasm Proteins Prostatic Neoplasms Humans Prostate-Specific Antigen Middle Aged Risk Factors Neoplasm Grading Aged Genetic Predisposition to Disease Prostate Male Polymorphism, Single Nucleotide Biopsy Genotype GPI-Linked Proteins
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Finding disagreement pathway signatures and constructing an ensemble model for cancer classification.

Scientific reports Aug 30, 2017
Cancer classification based on molecular level is a relatively routine research procedure with advances in high-throughput molecular profiling techniques. However, the number of genes typically far exceeds the number of the sample size in gene expres...
Neoplasm Proteins Datasets as Topic Oligonucleotide Array Sequence Analysis Taxoids Atlases as Topic Anthracyclines Humans Gene Expression Profiling Neoplasms Gene Regulatory Networks Antineoplastic Agents Gene Expression Regulation, Neoplastic Signal Transduction Support Vector Machine
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and cell-based analyses reveal strong divergence between prediction and observation of T-cell-recognized tumor antigen T-cell epitopes.

The Journal of biological chemistry May 23, 2017
Tumor exomes provide comprehensive information on mutated, overexpressed genes and aberrant splicing, which can be exploited for personalized cancer immunotherapy. Of particular interest are mutated tumor antigen T-cell epitopes, because neoepitope-s...
Antigens, Neoplasm Vaccines, Synthetic Membrane Proteins Neoplasm Proteins Mice, Knockout Reproducibility of Results Animals Computational Biology Cancer Vaccines Oligopeptides Immunogenicity, Vaccine Mice, Transgenic Models, Immunological Protein Refolding Peptide Fragments Epitopes HLA-A2 Antigen Protein Stability Expert Systems Humans T-Lymphocytes, Cytotoxic Artificial Intelligence Cells, Cultured Melanoma
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Computational methods using genome-wide association studies to predict radiotherapy complications and to identify correlative molecular processes.

Scientific reports Feb 24, 2017
The biological cause of clinically observed variability of normal tissue damage following radiotherapy is poorly understood. We hypothesized that machine/statistical learning methods using single nucleotide polymorphism (SNP)-based genome-wide associ...
Rectum Hemorrhage Erectile Dysfunction Radiation Tolerance Gene Expression Regulation, Neoplastic Gamma Rays Signal Transduction Neoplasm Proteins Prostatic Neoplasms Prostate Middle Aged Genome-Wide Association Study Cohort Studies Humans Polymorphism, Single Nucleotide Machine Learning Prognosis Aged Biomarkers, Tumor Male
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Loss of the integral nuclear envelope protein SUN1 induces alteration of nucleoli.

Nucleus (Austin, Tex.) Mar 10, 2016
A supervised machine learning algorithm, which is qualified for image classification and analyzing similarities, is based on multiple discriminative morphological features that are automatically assembled during the learning processes. The algorithm ...
Cell Line, Tumor Membrane Proteins Nuclear Proteins Neoplasm Proteins Microtubule-Associated Proteins RNA, Ribosomal RNA, Neoplasm Cell Nucleolus Nuclear Envelope Humans Machine Learning Algorithms Female Breast Neoplasms
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Drug repositioning for non-small cell lung cancer by using machine learning algorithms and topological graph theory.

BMC bioinformatics Jan 11, 2016
BACKGROUND: Non-small cell lung cancer (NSCLC) is one of the leading causes of death globally, and research into NSCLC has been accumulating steadily over several years. Drug repositioning is the current trend in the pharmaceutical industry for ident...
Carcinoma, Non-Small-Cell Lung Neoplasm Proteins Drug Repositioning Microarray Analysis Antineoplastic Agents Humans Lung Neoplasms Machine Learning Gene Expression Regulation, Neoplastic Algorithms Signal Transduction Drug Discovery Models, Theoretical
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canSAR: an updated cancer research and drug discovery knowledgebase.

Nucleic acids research Dec 15, 2015
canSAR (http://cansar.icr.ac.uk) is a publicly available, multidisciplinary, cancer-focused knowledgebase developed to support cancer translational research and drug discovery. canSAR integrates genomic, protein, pharmacological, drug and chemical da...
Neoplasm Proteins Gene Expression Knowledge Bases Clinical Trials as Topic Animals Neoplasms Drug Discovery Antineoplastic Agents Cell Line, Tumor Humans
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