AIMC Topic: Non-alcoholic Fatty Liver Disease
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Targeted metabolomics reveals bioactive inflammatory mediators from gut into blood circulation in children with NAFLD.
NPJ biofilms and microbiomes
Jul 1, 2025
Altered gut metabolites are important for the inflammatory progression in children with NAFLD. Fecal and plasma samples were collected from 145 subjects including 53 non-alcoholic fatty liver (NAFL), 39 nonalcoholic steatohepatitis (NASH) and 53 obes...
Therapeutic horizons in metabolic dysfunction-associated steatohepatitis.
The Journal of clinical investigation
Jul 1, 2025
Metabolic dysfunction-associated steatohepatitis (MASH), the progressive inflammatory form of MASLD, is now a leading cause of chronic liver disease worldwide. Driven by obesity and type 2 diabetes, MASH significantly increases the risk of cirrhosis,...
CDKN1A and EGR1 are key genes for endoplasmic reticulum stress-induced ferroptosis in MASH.
Free radical biology & medicine
May 23, 2025
Metabolic dysfunction-associated steatohepatitis (MASH) is a complex liver disease whose pathogenesis involving endoplasmic reticulum (ER) stress and ferroptosis. However, key regulatory genes remain poorly understood, hindering the development of ef...
Diet, High-Fat
Ferroptosis
Non-alcoholic Fatty Liver Disease
Phenylenediamines
Early Growth Response Protein 1
Gene Expression Regulation
Endoplasmic Reticulum Stress
Cyclin-Dependent Kinase Inhibitor p21
Mice, Inbred C57BL
Liver
Fatty Liver
Disease Models, Animal
Male
Hep G2 Cells
Mice
Humans
Animals
Unraveling MASLD: The Role of Gut Microbiota, Dietary Modulation, and AI-Driven Lifestyle Interventions.
Nutrients
May 4, 2025
Gut microbiota has a crucial role in the pathophysiology of metabolic-associated steatotic liver disease (MASLD), influencing various metabolic mechanisms and contributing to the development of the disease. Dietary interventions targeting gut microbi...
Assessing the diagnostic accuracy of ChatGPT-4 in the histopathological evaluation of liver fibrosis in MASH.
Hepatology communications
Apr 30, 2025
BACKGROUND: Large language models like ChatGPT have demonstrated potential in medical image interpretation, but their efficacy in liver histopathological analysis remains largely unexplored. This study aims to assess ChatGPT-4-vision's diagnostic acc...
Multiscale insights into cornuside's effects on NAFLD: A cross-disciplinary integrating bioinformatics, computational chemistry, and machine learning.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Apr 26, 2025
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a complex metabolic disorder involving intertwined signaling pathways, posing challenges for targeted therapeutic interventions. Cornus Fructus (CF), a traditional medicinal herb, holds potenti...
Machine learning-based disease risk stratification and prediction of metabolic dysfunction-associated fatty liver disease using vibration-controlled transient elastography: Result from NHANES 2021-2023.
BMC gastroenterology
Apr 14, 2025
BACKGROUND: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a common chronic liver disease and represents a significant public health issue. Nevertheless, current risk stratification methods remain inadequate. The study aimed to use m...
Machine learning-based integration reveals reliable biomarkers and potential mechanisms of NASH progression to fibrosis.
Scientific reports
Apr 11, 2025
Non-alcoholic fatty liver disease (NAFLD) affects about 25% of adults worldwide. Its advanced form, non-alcoholic steatohepatitis (NASH), is a major cause of liver fibrosis, but there are no non-invasive tests for diagnosing or preventing it. In our ...
Preclinical evidence construction for epigallocatechin-3-gallate against non-alcoholic fatty liver disease: a meta-analysis and machine learning study.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Apr 10, 2025
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant health concern worldwide, exhibiting an increasing incidence that necessitates immediate intervention. Epigallocatechin-3-gallate (EGCG) has shown significant pharmaco...
Identification of CACNB1 protein as an actionable therapeutic target for hepatocellular carcinoma via metabolic dysfunction analysis in liver diseases: An integrated bioinformatics and machine learning approach for precise therapy.
International journal of biological macromolecules
Mar 25, 2025
In addition to histological evaluation for nonalcoholic fatty liver disease (NAFLD), a comprehensive analysis of the metabolic landscape is urgently needed to categorize patients into distinct subgroups for precise treatment. In this study, a total o...
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