AIMC Topic: Oxidative Stress
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Unraveling the oxidative stress landscape in diabetic foot ulcers: insights from bulk RNA and single-cell RNA sequencing data.
Biology direct
Jul 4, 2025
BACKGROUND: Oxidative stress plays a crucial role in the development of diabetic foot ulcers (DFU). However, its underlying mechanisms are not fully understood. The purpose of this study was to use bioinformatics and preliminary validation methods to...
Identification and verification of immune and oxidative stress-related diagnostic indicators for malignant lung nodules through WGCNA and machine learning.
Scientific reports
Jul 1, 2025
Early detection of lung nodules (LNs) is critical for prevention and treatment of lung cancer. However, current noninvasive diagnostic methods face significant challenges in reliably distinguishing benign from malignant nodules. Thus, there is an urg...
Machine learning reveals genes impacting oxidative stress resistance across yeasts.
Nature communications
Jul 1, 2025
Reactive oxygen species (ROS) are highly reactive molecules encountered by yeasts during routine metabolism and during interactions with other organisms, including host infection. Here, we characterize the variation in resistance to the ROS-inducing ...
From neurotoxicity to neuroprotection: Rethinking GABAR-targeting anesthetics.
Cell biology and toxicology
Jun 14, 2025
The brain growth spurt (BGS) represents a pivotal window in neurodevelopment, defined by rapid neurogenesis, heightened synaptogenesis, and the dynamic establishment of neural networks. During this phase, heightened brain plasticity significantly enh...
An integrated analytical approach for biomarker discovery in esophageal cancer: Combining trace element and oxidative stress profiling with machine learning.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
May 28, 2025
BACKGROUND: Early detection of esophageal squamous cell carcinoma (ESCC) significantly improves survival rates, yet reliable biochemical biomarkers for early diagnosis remain limited. The aim of this study is to identify potential early diagnostic bi...
Eyes Are the Windows to the Soul: Reviewing the Possible Use of the Retina to Indicate Traumatic Brain Injury.
International journal of molecular sciences
May 28, 2025
Traumatic brain injury (TBI) induces complex molecular and cellular responses, often leading to vision deterioration and potential mortality. Current objective diagnostic methods are limited, necessitating the development of novel tools to assess dis...
Aging at the Crossroads of Organ Interactions: Implications for the Heart.
Circulation research
May 22, 2025
Aging processes underlie common chronic cardiometabolic diseases such as heart failure and diabetes. Cross-organ/tissue interactions can accelerate aging through cellular senescence, tissue wasting, accelerated atherosclerosis, increased vascular sti...
Effect of PUFAs-ω3 and ω6 on oxidative stress of sheep erythrocytes.
BMC veterinary research
May 10, 2025
BACKGROUND: In recent years, the use of long-chain polyunsaturated fatty acids (PUFA) ω3 and ω6, as food supplements in livestock has increased due to their beneficial properties related to their antioxidant activity. It has been demonstrated however...
Mechanism Exploration of Dietary Supplement Astaxanthin on Improving Atherosclerosis through an Integrated Strategy Encompassing Artificial Intelligence Virtual Screening and Experimental Validation.
Journal of agricultural and food chemistry
Apr 23, 2025
Atherosclerosis (AS) is a major and common pathological basis of ischemic intestinal infarction, myocardial infarction, stroke, renal failure, and other highly lethal and disabling diseases. Current pharmacological interventions (e.g., statins) often...
Revealing the Oxidative Stress-Related Molecular Characteristics and Potential Therapeutic Targets of Schizophrenia through Integrated Gene Expression Data Analysis.
Molecular neurobiology
Apr 11, 2025
Schizophrenia is a severe mental disorder characterized by oxidative stress imbalances. The underlying mechanisms of oxidative stress-related gene expression in schizophrenia require further investigation. Additionally, the diagnosis of schizophrenia...
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