AIMC Topic: Peptide Fragments

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Serum level of interleukin-6 (IL-6) and N-terminal propeptide of procollagen type I (PINP) in patients with liver diseases.

Scandinavian journal of clinical and laboratory investigation Dec 22, 2017
INTRODUCTION: The aim of this study was to evaluate the concentration of interleukin-6 and N-terminal propeptide of procollagen type I and their relationship in liver diseases of different etiologies.
Middle Aged Case-Control Studies ROC Curve Peptide Fragments Liver Diseases Female Aged Adult Male Procollagen Humans Interleukin-6
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Specific and intrinsic sequence patterns extracted by deep learning from intra-protein binding and non-binding peptide fragments.

Scientific reports Nov 2, 2017
The key finding in the DNA double helix model is the specific pairing or binding between nucleotides A-T and C-G, and the pairing rules are the molecule basis of genetic code. Unfortunately, no such rules have been discovered for proteins. Here we sh...
Databases, Protein Peptide Fragments Amino Acid Sequence Protein Conformation Binding Sites Algorithms Deep Learning Protein Binding Proteins
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A machine learning approach for the identification of new biomarkers for knee osteoarthritis development in overweight and obese women.

Osteoarthritis and cartilage Sep 9, 2017
OBJECTIVE: Knee osteoarthritis (OA) is among the higher contributors to global disability. Despite its high prevalence, currently, there is no cure for this disease. Furthermore, the available diagnostic approaches have large precision errors and low...
Heuristics Fruit Arthralgia Osteoarthritis, Knee Collagen Type I Obesity Muscle Strength Quadriceps Muscle Principal Component Analysis Peptide Fragments Collagen Type II Humans Machine Learning Biomarkers Female Reproducibility of Results Middle Aged Diet Comorbidity Incidence Overweight
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The effect of percutaneous coronary revascularization on plasma N-terminal pro-B-type natriuretic peptide levels in stable coronary artery disease.

Indian heart journal Aug 16, 2017
BACKGROUND: This study was conducted to assess the effect of percutaneous coronary revascularization (PCR) on plasma NT-proBNP concentration in patients with chronic stable angina (CSA).
Electrocardiography Aged Adult Follow-Up Studies Male Coronary Angiography Middle Aged Peptide Fragments Time Factors Percutaneous Coronary Intervention Humans Prospective Studies Coronary Artery Disease Biomarkers Natriuretic Peptide, Brain Female Angina, Stable
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In silico identification of milk antihypertensive di- and tripeptides involved in angiotensin I-converting enzyme inhibitory activity.

Nutrition research (New York, N.Y.) Jul 28, 2017
Identification of bioactive milk peptides could improve food technology through improved selection of food supplements with a focus on antihypertensive properties. We hypothesized that angiotensin I-converting enzyme (ACE) inhibitory activities of mi...
Hydrogen Bonding Peptidyl-Dipeptidase A Proteolysis Binding Sites Milk Proteins Oligopeptides Angiotensin-Converting Enzyme Inhibitors Quantitative Structure-Activity Relationship Protein Conformation Peptide Fragments Dipeptides Hydrophobic and Hydrophilic Interactions Expert Systems Catalytic Domain Cattle Computational Biology Dietary Supplements Antihypertensive Agents Models, Molecular Humans Animals Molecular Docking Simulation
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and cell-based analyses reveal strong divergence between prediction and observation of T-cell-recognized tumor antigen T-cell epitopes.

The Journal of biological chemistry May 23, 2017
Tumor exomes provide comprehensive information on mutated, overexpressed genes and aberrant splicing, which can be exploited for personalized cancer immunotherapy. Of particular interest are mutated tumor antigen T-cell epitopes, because neoepitope-s...
Protein Refolding T-Lymphocytes, Cytotoxic Expert Systems Oligopeptides Immunogenicity, Vaccine Mice, Transgenic Models, Immunological Cells, Cultured Melanoma Reproducibility of Results Animals Computational Biology Humans Artificial Intelligence Mice, Knockout Peptide Fragments Epitopes HLA-A2 Antigen Protein Stability Cancer Vaccines Antigens, Neoplasm Vaccines, Synthetic Membrane Proteins Neoplasm Proteins
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A genotypic method for determining HIV-2 coreceptor usage enables epidemiological studies and clinical decision support.

Retrovirology Dec 20, 2016
BACKGROUND: CCR5-coreceptor antagonists can be used for treating HIV-2 infected individuals. Before initiating treatment with coreceptor antagonists, viral coreceptor usage should be determined to ensure that the virus can use only the CCR5 corecepto...
HIV-2 Receptors, CCR5 HIV Infections Decision Support Systems, Clinical Genotype Support Vector Machine Receptors, CXCR4 Peptide Fragments Internet CCR5 Receptor Antagonists Genotyping Techniques HIV Envelope Protein gp120 Humans
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Cardiac Biomarkers of Low Cardiac Output Syndrome in the Postoperative Period After Congenital Heart Disease Surgery in Children.

Revista espanola de cardiologia (English ed.) Oct 27, 2016
INTRODUCTION AND OBJECTIVES: To assess the predictive value of atrial natriuretic peptide, β-type natriuretic peptide, copeptin, mid-regional pro-adrenomedullin (MR-proADM) and cardiac troponin I (cTn-I) as indicators of low cardiac output syndrome i...
Adrenomedullin Cardiopulmonary Bypass Protein Precursors Analysis of Variance Heart Defects, Congenital Cardiac Output, Low Child Operative Time Troponin Peptide Fragments Male Postoperative Complications Infant Pilot Projects Child, Preschool Humans Biomarkers Female Infant, Newborn
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Predictive value of circulating osteonectin in patients with ischemic symptomatic chronic heart failure.

Biomedical journal Feb 19, 2016
BACKGROUND: Osteonectin (OSN) plays a pivotal role in cardiac remodeling, but predictive value for OSN in ischemic chronic heart failure (CHF) has not been defined. The aim of the study was to evaluate the prognostic value of OSN for cumulative survi...
Humans Prospective Studies Female Aged Male Middle Aged Chronic Disease Peptide Fragments Heart Failure Natriuretic Peptide, Brain Myocardial Ischemia Osteonectin
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Identification of Peptide Inhibitors of Enveloped Viruses Using Support Vector Machine.

PloS one Dec 4, 2015
The peptides derived from envelope proteins have been shown to inhibit the protein-protein interactions in the virus membrane fusion process and thus have a great potential to be developed into effective antiviral therapies. There are three types of ...
Peptide Fragments Viral Envelope Proteins Sequence Analysis, Protein Viral Fusion Protein Inhibitors Protein Binding Support Vector Machine
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