AIMC Topic: Prospective Studies

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[Expert systems-urgently needed for early diagnosis of sepsis : Results of retrospective clinical validation of the expert system FLORIDA].

Medizinische Klinik, Intensivmedizin und Notfallmedizin
The expert system FLORIDA (Fuzzy Logic Orientated Rule Interpreter for Diagnostic Applications) is equipped with a knowledge base applying linguistic rules of clinical experts according to the pathophysiologic conception of the sepsis-3 definition an...

When robots care: Public deliberations on how technology and humans may support independent living for older adults.

Social science & medicine (1982)
While assistive robots receive growing attention as a potential solution to support older adults to live independently, several scholars question the underlying social, ethical and health policy assumptions. One perplexing issue is determining whethe...

Bioimpedance and New-Onset Heart Failure: A Longitudinal Study of >500 000 Individuals From the General Population.

Journal of the American Heart Association
BACKGROUND: Heart failure constitutes a high burden on patients and society, but although lifetime risk is high, it is difficult to predict without costly or invasive testing. We aimed to establish new risk factors of heart failure, which potentially...

Comparison of Models for Predicting Quality of Life After Surgical Resection of Hepatocellular Carcinoma: a Prospective Study.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
BACKGROUND: The essential issue of internal validity has not been adequately addressed in prediction models such as artificial neural network (ANN), support vector machine (SVM), Gaussian process regression (GPR), and multiple linear regression (MLR)...

A Nasal Brush-based Classifier of Asthma Identified by Machine Learning Analysis of Nasal RNA Sequence Data.

Scientific reports
Asthma is a common, under-diagnosed disease affecting all ages. We sought to identify a nasal brush-based classifier of mild/moderate asthma. 190 subjects with mild/moderate asthma and controls underwent nasal brushing and RNA sequencing of nasal sam...

Plasminogen activator inhibitor-1 is associated with the metabolism and development of advanced colonic polyps.

Translational research : the journal of laboratory and clinical medicine
Implications of plasminogen activator inhibitor-1 (PAI-1) in colonic polyps remain elusive. A prospective study was conducted with 188 consecutive subjects who underwent colonoscopy at a tertiary referral center. Biochemical parameters, serum PAI-1 l...

Assessment of the Diagnostic Accuracy of Biparametric Magnetic Resonance Imaging for Prostate Cancer in Biopsy-Naive Men: The Biparametric MRI for Detection of Prostate Cancer (BIDOC) Study.

JAMA network open
IMPORTANCE: Multiparametric magnetic resonance imaging (MRI) enhances detection and risk stratification for significant prostate cancer but is time-consuming (approximately 40 minutes) and expensive. Rapid and simpler (approximately 15-minute) bipara...

Effects of robot-assisted gait training in chronic stroke patients treated by botulinum toxin-a: A pivotal study.

Physiotherapy research international : the journal for researchers and clinicians in physical therapy
OBJECTIVE: To investigate combined effects of robot-assisted training (RAT) and physical therapy versus physical therapy only on balance and gait function of chronic stroke patients after botulinum toxin-A (BoNT-A) treatment.

A metabolomics-based approach for non-invasive screening of fetal central nervous system anomalies.

Metabolomics : Official journal of the Metabolomic Society
BACKGROUND: Central nervous system anomalies represent a wide range of congenital birth defects, with an incidence of approximately 1% of all births. They are currently diagnosed using ultrasound evaluation. However, there is strong need for a more a...