AIMC Topic: Reproducibility of Results

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Identification of aberrantly methylated‑differentially expressed genes and gene ontology in prostate cancer.

Molecular medicine reports
Prostate cancer (PCa) is the most frequent urological malignancy in men worldwide. DNA methylation has an essential role in the etiology and pathogenesis of PCa. The purpose of the present study was to identify the aberrantly methylated‑differentiall...

Time-resolved evaluation of compound repositioning predictions on a text-mined knowledge network.

BMC bioinformatics
BACKGROUND: Computational compound repositioning has the potential for identifying new uses for existing drugs, and new algorithms and data source aggregation strategies provide ever-improving results via in silico metrics. However, even with these a...

Evaluating the reliability of neurocognitive biomarkers of neurodegenerative diseases across countries: A machine learning approach.

NeuroImage
Accurate early diagnosis of neurodegenerative diseases represents a growing challenge for current clinical practice. Promisingly, current tools can be complemented by computational decision-support methods to objectively analyze multidimensional meas...

An enhanced deep learning approach for brain cancer MRI images classification using residual networks.

Artificial intelligence in medicine
Cancer is the second leading cause of death after cardiovascular diseases. Out of all types of cancer, brain cancer has the lowest survival rate. Brain tumors can have different types depending on their shape, texture, and location. Proper diagnosis ...

Accurate Ambulatory Gait Analysis in Walking and Running Using Machine Learning Models.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
Wearable sensors have been proposed as alternatives to traditional laboratory equipment for low-cost and portable real-time gait analysis in unconstrained environments. However, the moderate accuracy of these systems currently limits their widespread...

Body Composition Analysis of Computed Tomography Scans in Clinical Populations: The Role of Deep Learning.

Lifestyle genomics
BACKGROUND: Body composition is increasingly being recognized as an important prognostic factor for health outcomes across cancer, liver cirrhosis, and critically ill patients. Computed tomography (CT) scans, when taken as part of routine care, provi...

Active generation and magnetic actuation of microrobotic swarms in bio-fluids.

Nature communications
In nature, various types of animals will form self-organised large-scale structures. Through designing wireless actuation methods, microrobots can emulate natural swarm behaviours, which have drawn extensive attention due to their great potential in ...

Multi-Institutional Validation of Deep Learning for Pretreatment Identification of Extranodal Extension in Head and Neck Squamous Cell Carcinoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology
PURPOSE: Extranodal extension (ENE) is a well-established poor prognosticator and an indication for adjuvant treatment escalation in patients with head and neck squamous cell carcinoma (HNSCC). Identification of ENE on pretreatment imaging represents...

Decoding and mapping task states of the human brain via deep learning.

Human brain mapping
Support vector machine (SVM)-based multivariate pattern analysis (MVPA) has delivered promising performance in decoding specific task states based on functional magnetic resonance imaging (fMRI) of the human brain. Conventionally, the SVM-MVPA requir...