AIMC Topic: Vancomycin
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Prediction of vancomycin dose on high-dimensional data using machine learning techniques.
Expert review of clinical pharmacology
Apr 9, 2021
OBJECTIVES: Despite therapeutic vancomycin is regularly monitored, its dose requirements vary considerably between individuals. Various innovative vancomycin dosing strategies have been developed for dose optimization; however, the utilization of ind...
Validation of the usefulness of artificial neural networks for risk prediction of adverse drug reactions used for individual patients in clinical practice.
PloS one
Jul 29, 2020
Artificial neural networks are the main tools for data mining and were inspired by the human brain and nervous system. Studies have demonstrated their usefulness in medicine. However, no studies have used artificial neural networks for the prediction...
Initial dosing of intermittent vancomycin in adults: estimation of dosing interval in relation to dose and renal function.
European journal of hospital pharmacy : science and practice
Aug 7, 2019
OBJECTIVES: Due to the high interindividual variability in vancomycin pharmacokinetics, optimisation of its dosing is still challenging. This study aimed to explore vancomycin pharmacokinetics in adult patients and to propose an easy applicable dosin...
An attention based deep learning model of clinical events in the intensive care unit.
PloS one
Feb 13, 2019
This study trained long short-term memory (LSTM) recurrent neural networks (RNNs) incorporating an attention mechanism to predict daily sepsis, myocardial infarction (MI), and vancomycin antibiotic administration over two week patient ICU courses in ...
Synergism of prenylflavonoids from Morus alba root bark against clinical MRSA isolates.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Dec 21, 2017
BACKGROUND: Clinical methicillin-resistant Staphylococcus aureus (MRSA) is a thorny problem in current anti-infective therapeutics and a challenge of new drug development. Plant prenylflavonoids possess anti-MRSA activity, but few of the prenylflavon...
Stability-indicating spectrofluorimetric method with enhanced sensitivity for determination of vancomycin hydrochloride in pharmaceuticals and spiked human plasma: Application to degradation kinetics.
Journal of food and drug analysis
Jul 8, 2017
Based on investigating the relative fluorescence intensity of vancomycin hydrochloride (VCM) in methanol, a simple, highly sensitive, time-saving and specific spectrofluorimetric method was developed and validated. VCM fluorescence was measured at 33...
Superficial Vancomycin Coating of Bone Cement in Orthopedic Revision Surgery: A Safe Technique to Enhance Local Antibiotic Concentrations.
The Journal of arthroplasty
Dec 1, 2016
BACKGROUND: The use of antibiotic-loaded cement has become a well-accepted method to develop high local antibiotic concentrations in revision surgery of infected arthroplasty. A new surgical technique has been established to further increase the loca...
Serum and Wound Vancomycin Levels After Intrawound Administration in Primary Total Joint Arthroplasty.
The Journal of arthroplasty
Oct 26, 2015
BACKGROUND: Periprosthetic joint infection is the most common cause of readmissions after total joint arthroplasty (TJA). Intrawound vancomycin powder (VP) has reduced infection rates in spine surgery; however, there are no data regarding VP in prima...
Characterization of fecal vancomycin-resistant enterococci with acquired and intrinsic resistance mechanisms in wild animals, Spain.
Microbial ecology
Jul 21, 2015
The objectives were to evaluate the presence of vancomycin-resistant enterococci with acquired (VRE-a) and intrinsic (VRE-i) resistance mechanisms in fecal samples from different wild animals, and analyze their phenotypes and genotypes of antimicrobi...
Microbial Sensitivity Tests
Drug Resistance, Multiple, Bacterial
Feces
Animals
Animals, Wild
Enterococcus faecium
Falconiformes
Bacterial Proteins
Galliformes
Spain
Tetracycline Resistance
Sus scrofa
Ampicillin
Tetracycline
Vancomycin-Resistant Enterococci
Ampicillin Resistance
Vancomycin
Aminoglycosides
Carbon-Oxygen Ligases
Multilocus Sequence Typing
SERS based determination of ceftriaxone, ampicillin, and vancomycin in serum using WS/Au@Ag nanocomposites and a 2D-CNN regression model.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
May 15, 2025
Accurate therapeutic drug monitoring (TDM) of antibiotics including ceftriaxone, ampicillin, and vancomycin plays an important role in the treatment of neonatal sepsis, a common and life-threatening disease in neonates. A highly sensitive surface-enh...
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