AIMC Topic: Xenograft Model Antitumor Assays

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Experimental Research on the Antitumor Effect of Human Gastric Cancer Cells Transplanted in Nude Mice Based on Deep Learning Combined with Spleen-Invigorating Chinese Medicine.

Computational and mathematical methods in medicine Feb 12, 2022
Gastric cancer is still the fifth most common malignant tumor in the world and has the fourth highest mortality rate in the world. Gastric cancer is difficult to treat because of its unobvious onset, low resection rate, and rapid deterioration. There...
Algorithms Stomach Neoplasms Animals Deep Learning Cell Line, Tumor Humans Drugs, Chinese Herbal Fluorouracil Xenograft Model Antitumor Assays Spleen Phytotherapy Mice Computational Biology Medicine, Chinese Traditional Mice, Nude Antineoplastic Agents, Phytogenic
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Myricitrin inhibits vascular endothelial growth factor-induced angiogenesis of human umbilical vein endothelial cells and mice.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Sep 17, 2020
In the present study, the protective effects of myricitrin against vascular endothelial growth factor (VEGF)-induced angiogenesis of vascular endothelial cells were characterized. Cells were induced with 50 ng/mL VEGF in the presence or absence of va...
Human Umbilical Vein Endothelial Cells Mice Angiogenesis Inhibitors Caspases Vascular Endothelial Growth Factors Matrix Metalloproteinases Disease Models, Animal Humans Apoptosis Neovascularization, Pathologic Biomarkers Xenograft Model Antitumor Assays Flavonoids Neovascularization, Physiologic Animals Cell Line, Tumor
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Molecular imaging and deep learning analysis of uMUC1 expression in response to chemotherapy in an orthotopic model of ovarian cancer.

Scientific reports Sep 10, 2020
Artificial Intelligence (AI) algorithms including deep learning have recently demonstrated remarkable progress in image-recognition tasks. Here, we utilized AI for monitoring the expression of underglycosylated mucin 1 (uMUC1) tumor antigen, a biomar...
Molecular Imaging Xenograft Model Antitumor Assays Mucin-1 Tumor Cells, Cultured Female Animals Antineoplastic Agents Deep Learning Mice Cell Proliferation Mice, Nude Apoptosis Ovarian Neoplasms Docetaxel Humans Artificial Intelligence
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An Automated Segmentation Pipeline for Intratumoural Regions in Animal Xenografts Using Machine Learning and Saturation Transfer MRI.

Scientific reports May 15, 2020
Saturation transfer MRI can be useful in the characterization of different tumour types. It is sensitive to tumour metabolism, microstructure, and microenvironment. This study aimed to use saturation transfer to differentiate between intratumoural re...
Male Image Processing, Computer-Assisted Mice Cell Proliferation Adenocarcinoma Humans Machine Learning Algorithms Female Animals Xenograft Model Antitumor Assays Automation Magnetic Resonance Imaging Tumor Cells, Cultured Mice, Nude Apoptosis Prostatic Neoplasms
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Propofol affects the growth and metastasis of pancreatic cancer via ADAM8.

Pharmacological reports : PR Dec 20, 2019
BACKGROUND: Anesthesia is a major component of surgery and recently considered an important regulator of cell phenotypes. Here we aimed to investigate propofol, an anesthesia drug, in suppressing pancreatic cancer (PDAC), focusing on A disintegrin an...
Apoptosis Neoplasm Invasiveness Pancreatic Neoplasms Matrix Metalloproteinase 9 Matrix Metalloproteinase 2 Cell Line, Tumor Membrane Proteins Humans Cell Proliferation Animals Xenograft Model Antitumor Assays Propofol Antineoplastic Agents Cell Movement Neoplasm Metastasis MAP Kinase Signaling System ADAM Proteins Mice, SCID
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Efficient identification of novel anti-glioma lead compounds by machine learning models.

European journal of medicinal chemistry Dec 19, 2019
Glioblastoma multiforme (GBM) is the most devastating and widespread primary central nervous system tumor. Pharmacological treatment of this malignance is limited by the selective permeability of the blood-brain barrier (BBB) and relies on a single d...
Mice, Inbred C57BL Models, Statistical Xenograft Model Antitumor Assays Tumor Cells, Cultured Nitrofurans Antineoplastic Agents Mice Cell Proliferation Glioma Apoptosis Humans Machine Learning Female Animals Male
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An Intelligent DNA Nanorobot with Enhanced Protein Lysosomal Degradation of HER2.

Nano letters Jun 5, 2019
DNA nanorobots have emerged as new tools for nanomedicine with the potential to ameliorate the delivery and anticancer efficacy of various drugs. DNA nanostructures have been considered one of the most promising nanocarriers. In the present study, we...
Lysosomes Xenograft Model Antitumor Assays Receptor, ErbB-2 Proteolysis Endocytosis Mice Mice, Nude MCF-7 Cells Robotics DNA Breast Neoplasms Drug Delivery Systems Animals Aptamers, Nucleotide Humans Female
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Enhanced antitumor efficacy of doxorubicin-encapsulated halloysite nanotubes.

International journal of nanomedicine Dec 19, 2017
To improve the antitumor efficacy of doxorubicin (DOX) and provide novel clinical treatment of gastric cancer, halloysite nanotubes (HNTs) loaded with DOX were encapsulated by soybean phospholipid (LIP) and the formed HNTs/DOX/LIP was systematically ...
Humans Stomach Neoplasms Drug Delivery Systems Animals Mice, Nude Phospholipids Doxorubicin Drug Liberation Xenograft Model Antitumor Assays Nanotubes X-Ray Diffraction Clay Microscopy, Electron, Transmission Thermogravimetry Aluminum Silicates Tissue Distribution Antibiotics, Antineoplastic
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Salinomycin-loaded lipid-polymer nanoparticles with anti-CD20 aptamers selectively suppress human CD20+ melanoma stem cells.

Acta pharmacologica Sinica Dec 14, 2017
Melanoma is the deadliest type of skin cancer. CD20+ melanoma stem cells (CSCs) are pivotal for metastasis and initiation of melanoma. Therefore, selective elimination of CD20+ melanoma CSCs represents an effective treatment to eradicate melanoma. Sa...
Pyrans Drug Carriers Polyethylene Glycols Lecithins Xenograft Model Antitumor Assays Humans Antigens, CD20 Nanoparticles Melanoma Neoplastic Stem Cells Animals Mice, Inbred BALB C Antineoplastic Agents Particle Size Aptamers, Nucleotide
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Exploiting Metabolic Defects in Glioma with Nanoparticle-Encapsulated NAMPT Inhibitors.

Molecular cancer therapeutics Aug 1, 2024
The treatment of primary central nervous system tumors is challenging due to the blood-brain barrier and complex mutational profiles, which is associated with low survival rates. However, recent studies have identified common mutations in gliomas [is...
Brain Neoplasms Animals Cell Line, Tumor Mice Nanoparticles Humans Glioma Cytokines Nicotinamide Phosphoribosyltransferase Xenograft Model Antitumor Assays
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