AIMC Topic: Xenograft Model Antitumor Assays

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A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis.

Cancer research Jul 2, 2024
Patient-derived xenografts (PDX) model human intra- and intertumoral heterogeneity in the context of the intact tissue of immunocompromised mice. Histologic imaging via hematoxylin and eosin (H&E) staining is routinely performed on PDX samples, which...
Humans Animals Neoplasms Deep Learning Image Processing, Computer-Assisted Mice Genomics Lymphoproliferative Disorders Xenograft Model Antitumor Assays Heterografts
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Effects of Jiazhu decoction in combination with cyclophosphamide on breast cancer in mice.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Oct 1, 2019
OBJECTIVE: To investigate the therapeutic effects of Jiazhu decoction (JZD) in combination with cyclophosphamide (CTX) on the growth of breast cancer in mice and to explore the possible molecular mechanisms of action.
Breast Neoplasms Animals Antineoplastic Agents Cell Line, Tumor Mice RNA, Messenger Gene Expression Regulation, Neoplastic Cell Proliferation Drugs, Chinese Herbal Drug Interactions Xenograft Model Antitumor Assays Cyclin D1 Cyclophosphamide Genes, myc beta Catenin
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Redox-Responsive Amphipathic Dextran Nanomicelles for Solid Tumor Therapy.

Journal of biomedical nanotechnology Dec 1, 2016
A disulfide bond containing deoxycholic acid-grafted dextran (Dex-SSDCA) was successfully prepared for drug delivery. The Dex-SSDCA polymers can self-assemble into nanomicelles at concentrations below 56 g/mL and encapsulate doxorubicin (DOX) effecti...
Humans Animals Male Antineoplastic Agents Cell Line, Tumor Mice Nanoparticles Mice, Nude Apoptosis Cell Survival Drug Carriers MCF-7 Cells Oxidation-Reduction Doxorubicin Micelles Xenograft Model Antitumor Assays Dextrans Dithiothreitol
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