AIMC Topic: Adrenal Cortex Hormones

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Step up to triple therapy versus switch to dual bronchodilator therapy in patients with COPD on an inhaled corticosteroid/long-acting β-agonist: post-hoc analyses of KRONOS.

Respiratory research May 8, 2025
BACKGROUND: In people with chronic obstructive pulmonary disease (COPD) on inhaled corticosteroid/long-acting β-agonist (ICS/LABA) therapy, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommends stepping up to ICS/long-acting mu...
Humans Drug Substitution Muscarinic Antagonists Adrenal Cortex Hormones Administration, Inhalation Bronchodilator Agents Adrenergic beta-2 Receptor Agonists Middle Aged Treatment Outcome Drug Combinations Double-Blind Method Drug Therapy, Combination Female Aged Pulmonary Disease, Chronic Obstructive Male
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Could machine learning revolutionize how we treat immune thrombocytopenia?

British journal of haematology Aug 5, 2024
The absence of reliable biomarkers in immune thrombocytopenia (ITP) complicates treatment choice, necessitating a trial-and-error approach. Machine learning (ML) holds promise for transforming ITP treatment by analysing complex data to identify predi...
Receptors, Thrombopoietin Machine Learning Adrenal Cortex Hormones Rituximab Purpura, Thrombocytopenic, Idiopathic Humans
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Surveying haemoperfusion impact on COVID-19 from machine learning using Shapley values.

Inflammopharmacology May 19, 2024
BACKGROUND: Haemoperfusion (HP) is an innovative extracorporeal therapy that utilizes special cartridges to filter the blood, effectively removing pro-inflammatory cytokines, toxins, and pathogens in COVID-19 patients. This retrospective cohort study...
Adult Machine Learning Male Humans Middle Aged COVID-19 Retrospective Studies Treatment Outcome Iran Female Methylprednisolone COVID-19 Drug Treatment Aged Adrenal Cortex Hormones Hemoperfusion
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PRCTC: a machine learning model for prediction of response to corticosteroid therapy in COVID-19 patients.

Aging Jan 12, 2022
Corticosteroid has been proved to be one of the few effective treatments for COVID-19 patients. However, not all the patients were suitable for corticosteroid therapy. In this study, we aimed to propose a machine learning model to forecast the respon...
Humans Neural Networks, Computer Machine Learning Aged Male Middle Aged China Logistic Models COVID-19 Algorithms Retrospective Studies Female SARS-CoV-2 Treatment Outcome COVID-19 Drug Treatment Adrenal Cortex Hormones
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Machine Learning as a Precision-Medicine Approach to Prescribing COVID-19 Pharmacotherapy with Remdesivir or Corticosteroids.

Clinical therapeutics Mar 29, 2021
PURPOSE: Coronavirus disease-2019 (COVID-19) continues to be a global threat and remains a significant cause of hospitalizations. Recent clinical guidelines have supported the use of corticosteroids or remdesivir in the treatment of COVID-19. However...
Alanine Adenosine Monophosphate Middle Aged Adolescent Antiviral Agents COVID-19 Drug Treatment Adrenal Cortex Hormones Aged, 80 and over Young Adult Adult Male Humans Machine Learning Female Aged
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Granulomatosis with polyangiitis in Northeastern Brazil: study of 25 cases and review of the literature.

Advances in rheumatology (London, England) Jun 28, 2018
BACKGROUND: Little has been published about the epidemiology of Granulomatosis with polyangiitis (GPA) in South America, especially in the intertropical zone, and no epidemiological data from Brazil are available. The purpose of the present study was...
Disease Progression Arthritis Adult Lung Diseases Gastrointestinal Diseases Humans Proteinuria Cross-Sectional Studies Creatinine Granulomatosis with Polyangiitis Retrospective Studies Heart Diseases Male Skin Diseases Acute Kidney Injury Delayed Diagnosis Nervous System Diseases Middle Aged Female Eye Diseases Brazil Adrenal Cortex Hormones
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A Multicenter Study of Early Anti-inflammatory Treatment in Patients With Acute Anterior Cruciate Ligament Tear.

The American journal of sports medicine Oct 7, 2016
BACKGROUND: It is increasingly recognized that biochemical abnormalities of the joint precede radiographic abnormalities of posttraumatic osteoarthritis (PTOA) by as much as decades. A growing body of evidence strongly suggests that the progression f...
Humans Osteoarthritis Male Prospective Studies Kentucky Adolescent Anterior Cruciate Ligament Injuries Biomarkers Injections, Intra-Articular Inflammation Arthrocentesis Female Adrenal Cortex Hormones Anti-Inflammatory Agents Tennessee Young Adult Cartilage, Articular Pain
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Explainable artificial intelligence for prediction of refractory ulcerative colitis: analysis of a Japanese Nationwide Registry.

Annals of medicine Dec 1, 2025
OBJECTIVE: Ulcerative colitis (UC) is a chronic inflammatory bowel disease for which remission is dependent on corticosteroid (CS) treatment. The diversity of disease pathophysiology necessitates optimal case-specific treatment selection. This study ...
Young Adult Adult Male Artificial Intelligence Middle Aged Registries Humans Machine Learning Colitis, Ulcerative Remission Induction Prognosis Japan Female Adrenal Cortex Hormones Aged
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Multicenter target trial emulation to evaluate corticosteroids for sepsis stratified by predicted organ dysfunction trajectory.

Nature communications May 13, 2025
Corticosteroids decrease the duration of organ dysfunction in sepsis and a range of overlapping and complementary infectious critical illnesses, including septic shock, pneumonia and the acute respiratory distress syndrome (ARDS). The risk and benefi...
Humans Machine Learning Retrospective Studies Female Respiratory Distress Syndrome Pneumonia Multiple Organ Failure Organ Dysfunction Scores Adrenal Cortex Hormones Aged Male Middle Aged Sepsis Shock, Septic
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Predictors of bleeding event among elderly patients with mechanical valve replacement using random forest model: A retrospective study.

Medicine May 14, 2021
Available classification tools and risk factors predicting bleeding events in elderly patients after mechanical valve replacement may not be suitable in Asian populations. Thus, we aimed to identify an accurate model for predicting bleeding in elderl...
Heart Valve Prosthesis Implantation Adrenal Cortex Hormones Warfarin Stroke Myocardial Infarction Hemorrhage Humans Machine Learning Retrospective Studies Risk Factors Aged Risk Assessment Neoplasms Anticoagulants
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