AIMC Topic: Alkaline Phosphatase

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LucaPCycle: Illuminating microbial phosphorus cycling in deep-sea cold seep sediments using protein language models.

Nature communications May 26, 2025
Phosphorus is essential for life and critically influences marine productivity. Despite geochemical evidence of active phosphorus cycling in deep-sea cold seeps, the microbial processes involved remain poorly understood. Traditional sequence-based se...
Alkaline Phosphatase Phosphorus Seawater Geologic Sediments Archaea Phylogeny
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Integrating Machine Learning and Follow-Up Variables to Improve Early Detection of Hepatocellular Carcinoma in Tyrosinemia Type 1: A Multicenter Study.

International journal of molecular sciences Apr 18, 2025
Hepatocellular carcinoma (HCC) is a major complication of tyrosinemia type 1 (HT-1), an inborn error of metabolism affecting tyrosine catabolism. The risk of HCC is higher in late diagnoses despite treatment. Alpha-fetoprotein (AFP) is widely used to...
Liver Neoplasms Carcinoma, Hepatocellular Longitudinal Studies Follow-Up Studies Early Detection of Cancer Infant Adolescent Child, Preschool Child Humans Young Adult Machine Learning Adult alpha-Fetoproteins Retrospective Studies Biomarkers, Tumor Alkaline Phosphatase Female Male Alanine Transaminase Infant, Newborn Middle Aged Tyrosinemias
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Deep learning assisted prediction of osteogenic capability of orthopedic implant surfaces based on early cell morphology.

Acta biomaterialia Feb 1, 2025
The surface modification of titanium (Ti) and its alloys is crucial for improving their osteogenic capability, as their bio-inert nature limits effective osseointegration despite their prevalent use in orthopedic implants. However, these modification...
Humans Prostheses and Implants Osteogenesis Alkaline Phosphatase Surface Properties Animals Alloys Deep Learning Cell Differentiation Titanium
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Study on the Effect of Low Calcium Dialysate on Biochemical Profile of Adynamic Bone Disease in Patients on Maintenance Hemodialysis.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia Jan 17, 2024
In recent years, adynamic bone disease (ABD) has become a common skeletal lesion in adult patients with chronic kidney disease. We aimed to compare the effects of low calcium dialysate (LCD) and standard calcium dialysate of our facility [high calciu...
Calcium Humans Alkaline Phosphatase Adult Parathyroid Hormone Renal Dialysis Bone Diseases Dialysis Solutions Hypercalcemia
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Toxicity, genotoxicity, and carcinogenicity of 2-methylfuran in a 90-day comprehensive toxicity study in gpt delta rats.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Aug 13, 2022
2-Methylfuran (2-MF) exists naturally in foods and is used as a flavoring agent. Furan, the core structure of 2-MF, possesses hepatocarcinogenicity in rodents. Accumulation of toxicological information on furan derivatives is needed to elucidate thei...
Rats, Transgenic Carcinogens Female Animals Male Rats Furans Rats, Sprague-Dawley Pregnancy Flavoring Agents Dose-Response Relationship, Drug Glutathione Transferase Liver Mutagenicity Tests Placenta Rats, Inbred F344 DNA Damage Alkaline Phosphatase
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Biochemical algorithm to identify individuals with ALPL variants among subjects with persistent hypophosphatasaemia.

Orphanet journal of rare diseases Mar 3, 2022
BACKGROUND: Hypophosphatasia (HPP) is a rare and underdiagnosed condition characterized by deficient bone and teeth mineralization. The aim of this study was first, to evaluate the diagnostic utility of employing alkaline phosphatase (ALP) threshold ...
Alkaline Phosphatase Bone and Bones Hypophosphatasia Pyridoxal Phosphate Humans Machine Learning Adult
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Predictors of Stroke Outcome Extracted from Multivariate Linear Discriminant Analysis or Neural Network Analysis.

Journal of atherosclerosis and thrombosis Dec 9, 2020
AIM: The prediction of functional outcome is essential in the management of acute ischemic stroke patients. We aimed to explore the various prognostic factors with multivariate linear discriminant analysis or neural network analysis and evaluate the ...
Recovery of Function Predictive Value of Tests Ischemic Stroke Discriminant Analysis Alkaline Phosphatase Aged, 80 and over Male Middle Aged Regression Analysis Nutritional Status Multivariate Analysis Humans Neural Networks, Computer Machine Learning Prognosis Retrospective Studies Female Risk Factors Aged
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[Seasonal variations in 25-hydroxy vitamin D3, parathormone and alkaline phosphatase in school-aged children].

Revista chilena de pediatria Nov 5, 2020
INTRODUCTION: The main role of Vitamin D is to regulate calcium metabolism, whose main source is vitamin D3 ob tained mostly from the action of ultraviolet (UV) light on the skin.
Alkaline Phosphatase Parathyroid Hormone Humans Seasons Female Cross-Sectional Studies Male Child, Preschool Child Chile Calcifediol Calcium
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Development and Validation of Machine Learning Algorithms for Predicting Adverse Events After Surgery for Lumbar Degenerative Spondylolisthesis.

World neurosurgery Apr 25, 2020
BACKGROUND: Preoperative prognostication of adverse events (AEs) for patients undergoing surgery for lumbar degenerative spondylolisthesis (LDS) can improve risk stratification and help guide the surgical decision-making process. The aim of this stud...
Spondylolisthesis Clinical Decision Rules Sex Factors Young Adult Adult Prognosis Transplantation, Autologous Male Female Bone Transplantation Middle Aged Risk Factors Ilium Postoperative Complications Aged Serum Albumin Adolescent Aged, 80 and over Humans Logistic Models Neurosurgical Procedures Machine Learning Spinal Fusion Age Factors Algorithms Lumbar Vertebrae Decision Making Alkaline Phosphatase Functional Status
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Artificial neural network-based models used for predicting 28- and 90-day mortality of patients with hepatitis B-associated acute-on-chronic liver failure.

BMC gastroenterology Mar 13, 2020
BACKGROUND: This study aimed to develop prognostic models for predicting 28- and 90-day mortality rates of hepatitis B virus (HBV)-associated acute-on-chronic liver failure (HBV-ACLF) through artificial neural network (ANN) systems.
Male Hepatitis B Age Factors Acute-On-Chronic Liver Failure Hepatitis B e Antigens Alkaline Phosphatase Sodium gamma-Glutamyltransferase Bilirubin Prothrombin Time Prognosis Retrospective Studies Female Risk Factors Adult Humans Neural Networks, Computer Hepatic Encephalopathy
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