A detailed functional characterization of electrogenic cells, such as neurons and cardiomyocytes, by means of high-density microelectrode arrays (HD-MEAs) has emerged as a powerful approach for inferring cellular phenotypes and elucidating fundamenta...
Partitioning cells in open nanowells permits high confidence in single cell occupancy and enables flexibility in the development of different molecular assays. A challenge for this approach however is to print cells sufficiently quickly to enable exp...
The corticospinal tract (CST) is essential for forelimb-specific fine motor skills. In rodents, it undergoes extensive structural remodeling across development, injury, and disease states, with major implications for motor function. A vast body of li...
Ovarian cancer is a global silent killer in women and is the second most common cause of gynecologic cancer-related deaths. Despite significant research and advances in treatment, ovarian cancer treatment remains a challenge, as it is diagnosed in an...
Proceedings of the National Academy of Sciences of the United States of America
Sep 22, 2025
remains a leading cause of hospital-acquired infections, with its primary virulence factor, toxin B (TcdB), responsible for severe colitis and recurrent disease. The closely related toxin, TcsL, from , causes a rarer but often fatal toxic shock synd...
. The compound muscle action potential (CMAP) scan contains a muscle's detailed stimulus-activation information and thereby can be used for motor unit number estimation (MUNE). Due to the challenges in accurately obtaining the motor unit numbers from...
Ixodes scapularis ticks are the primary vector of Lyme disease (LD) in North America, and their range has expanded into southeastern and southcentral Canada with climate change. This study presents a comprehensive machine learning (ML) framework to e...
Bone cancer pain (BCP) is a complex condition that severely affects patients' quality of life, and its treatment remains challenging. Astaxanthin, a potent antioxidant with anti-inflammatory and neuroprotective effects, and celecoxib, a selective COX...
Artificial intelligence and machine learning are revolutionizing pharmaceutical research by enabling the rapid analysis of complex datasets and automating critical tasks throughout the drug-development process. In this review, we surveyed how artific...
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