AIMC Topic: Antihypertensive Agents

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Better Blood Pressure Control for Stroke Patients in the ICU: A Deep Reinforcement Learning with Supervised Guidance Approach for Adaptive Infusion Rate Tuning.

AMIA ... Annual Symposium proceedings. AMIA Symposium
Blood pressure variability (BPV) plays a critical role in vascular diseases, particularly in acute ischemic stroke patients in intensive care units (ICUs), where higher BPV correlates with increased mortality rates. Current interventions lack effecti...

Antihypertensive Activity of Sauromatum guttatum Mediated by Vasorelaxation and Myocardial Depressant Effects.

Arquivos brasileiros de cardiologia
BACKGROUND: Sauromatum guttatum (S. guttatum) is used in the treatment of blood disorders and reportedly has a spasmolytic activity through Ca2+ channel inhibition.

Ex-vivo antihypertensive and calcium channel blocking activity of Androsace foliosa n-hexane leaves fraction on isolated rabbit aorta.

Pakistan journal of pharmaceutical sciences
Hypertension is persistent elevation in blood pressure for 3-4 weeks. Estimated global prevalence of hypertension suggested that by the Year 2025 (29%) of adult worldwide are suffering from hypertension (1.56 billion). Hypertension complications are ...

An outcome model approach to transporting a randomized controlled trial results to a target population.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: Participants enrolled into randomized controlled trials (RCTs) often do not reflect real-world populations. Previous research in how best to transport RCT results to target populations has focused on weighting RCT data to look like the tar...

Clinical Value of Predicting Individual Treatment Effects for Intensive Blood Pressure Therapy.

Circulation. Cardiovascular quality and outcomes
BACKGROUND: The absolute risk reduction (ARR) in cardiovascular events from therapy is generally assumed to be proportional to baseline risk-such that high-risk patients benefit most. Yet newer analyses have proposed using randomized trial data to de...

Artificial neuronal networks (ANN) to model the hydrolysis of goat milk protein by subtilisin and trypsin.

The Journal of dairy research
The enzymatic hydrolysis of milk proteins yield final products with improved properties and reduced allergenicity. The degree of hydrolysis (DH) influences both technological (e.g., solubility, water binding capacity) and biological (e.g., angiotensi...

Pattern and predictors of urine protein excretion among patients with type 2 diabetes attending a single tertiary hospital in Lagos, Nigeria.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
Testing for proteinuria is used to screen for diabetic nephropathy. However, significant proportion of diabetics has normal urine protein excretion despite impaired renal function. We aimed to determine the factors predicting increased urine protein ...

Effects of Candesartan Cilexetil Compared with Amlodipine on Serum Asymmetric Dimethylarginine Levels in the Chronic Stage of Cerebral Infarction: A Preliminary Study.

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
OBJECTIVE: Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide synthase inhibitor and a marker of vascular endothelial damage. Angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker (ARB) are reported to reduce the s...

The Treatment of Autosomal Dominant Polycystic Kidney Disease.

Deutsches Arzteblatt international
BACKGROUND: About one in 2000 persons in Europe suffers from autosomal dominant polycystic kidney disease (ADPKD). The treatment of this disease up to the present has been limited to the management of complications.