AIMC Topic: Atherosclerosis

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Large Language Models in Patient Health Communication for Atherosclerotic Cardiovascular Disease: Pilot Cross-Sectional Comparative Analysis.

JMIR medical informatics
BACKGROUND: Large language models (LLMs) have emerged as promising tools for enhancing public access to medical information, particularly for chronic diseases such as atherosclerotic cardiovascular disease (ASCVD). However, their effectiveness in pat...

Correlation between atherogenic index of plasma and retinal vessels in the fundus: a cross-sectional study.

European journal of medical research
BACKGROUND: The Atherogenic Index of Plasma (AIP) is a novel logarithmic index that combines fasting triglyceride and high-density lipoprotein cholesterol (HDL-C) concentrations and is associated with the burden of atherosclerosis. Currently, the non...

Identification of key genes and regulatory networks associated with atherosclerotic carotid artery stenosis through comprehensive bioinformatics analysis and machine learning.

European journal of medical research
OBJECTIVE: To identify the potential diagnostic biomarkers and therapeutic targets of atherosclerotic carotid artery stenosis (ACAS), a comprehensive bioinformatics analysis was conducted to identify its related key genes and regulatory networks.

Predictive value of systemic inflammation response index for atherosclerotic cardiovascular disease risk in patients with hypercholesterolemia: a machine learning study with dual-cohort validation.

Lipids in health and disease
BACKGROUND: Residual cardiovascular risk persists in patients with hypercholesterolemia despite lipid-lowering therapy, underscoring the importance of inflammation in ASCVD development. This study evaluated the relationship between Systemic Inflammat...

Association between atherogenic index of plasma and sepsis in critically ill patients with ischemic stroke: a retrospective cohort study using propensity score and machine learning approaches.

Lipids in health and disease
BACKGROUND: Sepsis is a severe and frequent complication among ischemic stroke patients during hospitalization. The atherogenic index of plasma (AIP), as metabolism-related markers, are closely linked to inflammation. However, their relationship with...

Hierarchical random forest model, inflammation and oxidative stress as predictors of the atherogenic index of plasma and diabetes progression.

Scientific reports
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease that increases the risk of cardiovascular complications. The atherogenic index of plasma (AIP) is a risk marker for T2DM and cardiovascular disease on the basis of lipid profiles. T2DM an...

Small dense LDL: An underestimated driver of atherosclerosis (Review).

Molecular medicine reports
Cardiovascular disease remains the leading cause of death globally, despite advances in lipid‑lowering strategies. A distinct subfraction of low‑density lipoprotein (LDL) particles, known as small LDL (sdLDL; particle size, 15‑20 nm), has been found ...

Exploring potential associations and biomarkers linked polycystic ovarian syndrome with atherosclerosis via comprehensive bioinformatics analysis, machine learning, and animal experiments.

Functional & integrative genomics
Polycystic ovary syndrome (PCOS), a common endocrine condition affecting multiple systems, is tied to atherosclerosis (AS) progression among reproductive-aged women. The present study aimed to explore the underlying associations and uncover potential...

Machine Learning-Based Analysis of Lifestyle Risk Factors for Atherosclerotic Cardiovascular Disease: Retrospective Case-Control Study.

JMIR medical informatics
BACKGROUND: The risk of developing atherosclerotic cardiovascular disease (ASCVD) varies among individuals and is related to a variety of lifestyle factors in addition to the presence of chronic diseases.

Beyond unimodal analysis: Multimodal ensemble learning for enhanced assessment of atherosclerotic disease progression.

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Atherosclerosis is a leading cardiovascular disease typified by fatty streaks accumulating within arterial walls, culminating in potential plaque ruptures and subsequent strokes. Existing clinical risk scores, such as systematic coronary risk estimat...