Retinal OCT biomarker analysis by artificial intelligence (AI) has not previously been integrated with proteomics. Here, we combined the two techniques to elucidate novel molecular mechanisms in central retinal vein occlusion (CRVO). Proteomic data o...
Clinical pharmacology and therapeutics
Sep 1, 2025
In silico trials, utilizing mathematical models calibrated with clinical data, present a transformative approach to expedite drug development. We propose a virtual trial framework for chronic Hepatitis B, accurately simulating clinical protocols, pat...
This paper tested the relevance of two machine learning approaches (decision trees, DTs; and random forest models, RFs) applied to meat authentication. DT allow to select and rank potential biomarkers according to their respective discriminatory powe...
Chemotherapy is one of the most successful strategies for treating cancer. Unfortunately, up to 70 % of cancer survivors develop cognitive impairment during or after chemotherapy, which severely affects their quality of life. We first established a m...
Journal of pharmaceutical and biomedical analysis
Sep 1, 2025
Acute pancreatitis (AP) is a common gastrointestinal disease characterized by pancreatic cell damage and inflammation. Given the early clinical diagnosis and management challenges, exploring novel analytical frameworks from new orientations for inter...
Biochemical and biophysical research communications
Aug 30, 2025
BACKGROUND: Abdominal aortic aneurysm (AAA) is a common degenerative vascular disease characterized by progressive dilation of the abdominal aorta, which poses a life-threatening risk upon rupture. Lactate, a key metabolic byproduct and immunomodulat...
BACKGROUND: Gluconeogenesis is a critical metabolic pathway for maintaining glucose homeostasis, and its dysregulation can lead to glycometabolic disorders. This study aimed to identify hub biomarkers of these disorders to provide a theoretical found...
The identification of biomarkers for early diagnosis and monitoring the progression of Type 1 Diabetes (T1DM) is essential for improving disease management. This study integrates multi-omics data with machine learning to identify antioxidant stress p...
Clinica chimica acta; international journal of clinical chemistry
Aug 15, 2025
Early detection of Alzheimer's disease (AD) remains a formidable clinical challenge, but emerging blood-based assays show promise for identifying at-risk individuals long before cognitive symptoms arise. This is the first comprehensive synthesis comp...
The rapid transfer of volatiles from alveolar blood into the lungs and then out of the body in exhaled breath leads to the common and natural conclusion that these volatiles provide information on health and metabolic processes, with considerable pot...
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