AIMC Topic: Biomarkers

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Prediction of tuberculosis treatment outcomes using biochemical makers with machine learning.

BMC infectious diseases Feb 17, 2025
BACKGROUND: Tuberculosis (TB) continues to pose a significant threat to global public health. Enhancing patient prognosis is essential for alleviating the disease burden.
Adult Prognosis Male Female Humans Middle Aged Aged Machine Learning ROC Curve Treatment Outcome Young Adult Algorithms Biomarkers Antitubercular Agents Tuberculosis
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Key RNA-binding proteins in renal fibrosis: a comprehensive bioinformatics and machine learning framework for diagnostic and therapeutic insights.

Renal failure Feb 16, 2025
BACKGROUND: Renal fibrosis is a critical factor in chronic kidney disease progression, with limited diagnostic and therapeutic options. Emerging evidence suggests RNA-binding proteins (RBPs) are pivotal in regulating cellular mechanisms underlying fi...
Mice Computational Biology RNA-Binding Proteins Kidney Machine Learning Biomarkers Animals Single-Cell Analysis Renal Insufficiency, Chronic Humans Disease Models, Animal Fibrosis Ureteral Obstruction
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Stress hyperglycemia ratio and machine learning model for prediction of all-cause mortality in patients undergoing cardiac surgery.

Cardiovascular diabetology Feb 15, 2025
BACKGROUND: The stress hyperglycemia ratio (SHR) was developed to reduce the effects of long-term chronic glycemic factors on stress hyperglycemia levels, which was associated with adverse clinical outcomes. This study aims to evaluate the relationsh...
Time Factors Hospital Mortality Hyperglycemia Treatment Outcome Cardiac Surgical Procedures Stress, Physiological Predictive Value of Tests Cause of Death Humans Male Machine Learning Middle Aged Decision Support Techniques Risk Assessment Databases, Factual Blood Glucose Biomarkers Retrospective Studies Female Risk Factors Aged
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Identification of biomarkers associated with phagocytosis regulatory factors in coronary artery disease using machine learning and network analysis.

Mammalian genome : official journal of the International Mammalian Genome Society Feb 14, 2025
BACKGROUND: Coronary artery disease (CAD) is the leading cause of death worldwide, and aberrant phagocytosis may be involved in its development. Understanding this aspect may provide new avenues for prompt CAD diagnosis.
Syk Kinase Coronary Artery Disease Phagocytosis Receptors, IgG Gene Expression Profiling Toll-Like Receptor 2 Protein Interaction Maps Gene Regulatory Networks Databases, Genetic Polymorphism, Single Nucleotide Humans Computational Biology MicroRNAs Machine Learning Transcription Factors Interleukin-1beta Biomarkers
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A diagnostic model for sepsis using an integrated machine learning framework approach and its therapeutic drug discovery.

BMC infectious diseases Feb 14, 2025
BACKGROUND: Sepsis remains a life-threatening condition in intensive care units (ICU) with high morbidity and mortality rates. Some biomarkers commonly used in clinic do not have the characteristics of rapid and specific growth and rapid decline afte...
Humans Gene Expression Profiling Machine Learning Sepsis Algorithms Gene Regulatory Networks Biomarkers Drug Discovery Nomograms
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Developing a nomogram model for predicting non-obstructive azoospermia using machine learning techniques.

Scientific reports Feb 14, 2025
Azoospermia, defined by the absence of sperm in the ejaculate, manifests as obstructive azoospermia (OA) or non-obstructive azoospermia (NOA). Reliable predictive models utilizing biomarkers could aid in clinical decision-making. This study included ...
Azoospermia Follicle Stimulating Hormone Humans Machine Learning Biomarkers Adult Logistic Models Nomograms Semen Analysis Male ROC Curve
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Predicting antipsychotic responsiveness using a machine learning classifier trained on plasma levels of inflammatory markers in schizophrenia.

Translational psychiatry Feb 14, 2025
We apply machine learning techniques to navigate the multifaceted landscape of schizophrenia. Our method entails the development of predictive models, emphasizing peripheral inflammatory biomarkers, which are classified into treatment response subgro...
Biomarkers Female Adult Middle Aged Male Case-Control Studies Schizophrenia Humans Inflammation Clozapine Machine Learning Support Vector Machine Antipsychotic Agents
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Simultaneous detection of trace protein biomarkers from a single drop of blood using AI-enhanced smartphone-based digital microscopy.

Biosensors & bioelectronics Feb 13, 2025
The detection of early-stage diseases is often impeded by the low concentrations of protein biomarkers, necessitating sophisticated and costly technologies. In response, we have developed an advanced cyber-physical system that integrates blood plasma...
Humans Artificial Intelligence Biomarkers Quantum Dots Limit of Detection Equipment Design Microscopy, Fluorescence Carcinoembryonic Antigen Smartphone Biosensing Techniques Carbon Phosphopyruvate Hydratase
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Molecular structure of NRG-1 protein and its impact on adult hypertension and heart failure: A new clinical Indicator diagnosis based on advanced machine learning.

International journal of biological macromolecules Feb 11, 2025
The purpose of this study was to investigate the molecular structure of NRG-1 protein and its mechanism of action in adult hypertensive heart failure. The amino acid sequence of NRG-1 protein was analyzed by bioinformatics method. High-throughput seq...
Male Middle Aged Computational Biology Hypertension Machine Learning Biomarkers Female Adult Mutation Heart Failure Neuregulin-1 Humans
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Identification of critical biomarkers and immune infiltration in preeclampsia through bioinformatics and machine learning methods.

BMC pregnancy and childbirth Feb 11, 2025
BACKGROUND: Preeclampsia (PE) is a multisystem progressive disease that occurs during pregnancy. Previous studies have shown that the immune system is involved in the placental trophoblast function and the pathological process of uterine vascular rem...
Machine Learning Biomarkers Pregnancy Female Gene Expression Profiling Humans Pre-Eclampsia ROC Curve Gene Regulatory Networks Computational Biology Placenta
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