AIMC Topic: Biomarkers

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An unsupervised learning approach for clustering joint trajectories of Alzheimer's disease biomarkers: An application to ADNI Data.

Alzheimer's & dementia : the journal of the Alzheimer's Association
INTRODUCTION: Current models of Alzheimer's disease (AD) progression assume a common pattern and pathology, oversimplifying the heterogeneity of clinical AD.

Identification of ubiquitination-related key biomarkers and immune infiltration in Crohn's disease by bioinformatics analysis and machine learning.

Scientific reports
Crohn's disease (CD) is a chronic inflammatory bowel disease with an unknown etiology. Ubiquitination plays a significant role in the pathogenesis of CD. This study aimed to explore the functional roles of ubiquitination-related genes in CD. Differen...

Evaluation of an AI-Based Voice Biomarker Tool to Detect Signals Consistent With Moderate to Severe Depression.

Annals of family medicine
PURPOSE: Mental health screening is recommended by the US Preventive Services Task Force for all patients in areas where treatment options are available. Still, it is estimated that only 4% of primary care patients are screened for depression. The go...

Identification of Novel Biomarkers for Ischemic Stroke Through Integrated Bioinformatics Analysis and Machine Learning.

Journal of molecular neuroscience : MN
Ischemic stroke leads to permanent damage to the affected brain tissue, with strict time constraints for effective treatment. Predictive biomarkers demonstrate great potential in the clinical diagnosis of ischemic stroke, significantly enhancing the ...

Deep-Learning-Assisted Digital Fluorescence Immunoassay on Magnetic Beads for Ultrasensitive Determination of Protein Biomarkers.

Analytical chemistry
Digital fluorescence immunoassay (DFI) based on random dispersion magnetic beads (MBs) is one of the powerful methods for ultrasensitive determination of protein biomarkers. However, in the DFI, improving the limit of detection (LOD) is challenging s...

Low-Cost Raman Spectroscopy Setup Combined with a Machine Learning Model.

Sensors (Basel, Switzerland)
The diagnosis of kidney diseases presents significant challenges, including the reliance on variable and unstable biomarkers and the necessity for complex and expensive laboratory tests. Raman spectroscopy emerges as a promising technique for analyzi...

Enhanced detection of mild cognitive impairment in Alzheimer's disease: a hybrid model integrating dual biomarkers and advanced machine learning.

BMC geriatrics
Alzheimer's disease (AD) is a complex, progressive, and irreversible neurodegenerative disorder marked by cognitive decline and memory loss. Early diagnosis is the most effective strategy to slow the disease's progression. Mild Cognitive Impairment (...

Prognosis modelling of adverse events for post-PCI treated AMI patients based on inflammation and nutrition indexes.

BMC cardiovascular disorders
OBJECTIVE: This study aimed to evaluate the predictive performance of inflammatory and nutritional indices for adverse cardiovascular events (ACE) in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI) using...

Identification of potential biomarkers for 2022 Mpox virus infection: a transcriptomic network analysis and machine learning approach.

Scientific reports
Monkeypox virus (MPXV), a zoonotic pathogen, re-emerged in 2022 with the Clade IIb variant, raising global health concerns due to its unprecedented spread in non-endemic regions. Recent studies have shown that Clade IIb (2022 MPXV) is marked by uniqu...