Machine learning (ML) modeling on mass spectrometry (MS)-based shotgun data facilitates feature selection and disease modeling. However, batch-specific models often struggle with limited transferability and generalizability, necessitating data integr...
Liver cancer represents a significant cause of cancer-related mortality, with hepatocellular carcinoma (HCC) being the most prevalent forms. Computed tomography (CT) serves as the principal imaging modality for the diagnosis of liver tumors, particul...
OBJECTIVE: To develop and validate an integrated 2.5D deep learning (DL) and Radiomics model using gadoxetic acid-enhanced MRI hepatobiliary phase (HBP) images combined with clinical features for preoperative prediction of microvascular invasion (MVI...
Journal of computer-aided molecular design
Nov 8, 2025
The overexpression or activation of C-terminal Src kinase (CSK) has been recognized as a pivotal factor in the progression of hepatocellular carcinoma (HCC), positioning CSK as a promising therapeutic target. Despite this potential, no CSK-specific i...
BACKGROUND: Accurate stratification of recurrence risk after curative resection remains a critical challenge in the management of hepatocellular carcinoma (HCC). Dysregulated ceramide (CER) metabolism has been implicated in HCC progression and relaps...
We developed GlyTrait, a Python-based framework designed to enhance Glycomics analysis through the innovative calculation and interpretation of derived traits from -glycome data. Glycomics research often grapples with the interpretability and biologi...
BACKGROUND: Combination immunotherapies, such as pembrolizumab plus lenvatinib (PL), are commonly used in treatment for unresectable hepatocellular carcinoma (uHCC). However, it remains challenging to predict which patients will benefit from this the...
Hepatocellular carcinoma (HCC) is a biologically and clinically heterogeneous malignancy, whose initiation and progression are increasingly recognized to be driven by the aberrant regulation of programmed cell death (PCD) pathways. To elucidate this ...
OBJECTIVE: Microvascular invasion (MVI) is of great significance for the individualized treatment of hepatocellular carcinoma (HCC) and preoperative noninvasive prediction of MVI is still an urgent clinical problem. To explore the effects of differen...
BACKGROUND: Early diagnosis of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) is challenging. Models that combine novel biomarkers with clinical features may improve both early diagnosis and risk stratification, but f...
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