AIMC Topic: Cell Death
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celldeath: A tool for detection of cell death in transmitted light microscopy images by deep learning-based visual recognition.
PloS one
Jun 24, 2021
Cell death experiments are routinely done in many labs around the world, these experiments are the backbone of many assays for drug development. Cell death detection is usually performed in many ways, and requires time and reagents. However, cell dea...
Predicting direct hepatocyte toxicity in humans by combining high-throughput imaging of HepaRG cells and machine learning-based phenotypic profiling.
Archives of toxicology
Jun 12, 2020
Accurate prediction of drug- and chemical-induced hepatotoxicity remains to be a problem for pharmaceutical companies as well as other industries and regulators. The goal of the current study was to develop an in vitro/in silico method for the rapid ...
Toxicity Tests
Transcription Factor RelA
Chemical and Drug Induced Liver Injury
Primary Cell Culture
Cellular Senescence
Cell Death
Hepatocytes
High-Throughput Screening Assays
Actin Cytoskeleton
Proto-Oncogene Mas
Humans
Machine Learning
Dose-Response Relationship, Drug
Phenotype
Image Processing, Computer-Assisted
DNA Damage
Risk Assessment
Hep G2 Cells
Microscopy, Fluorescence
Machine Learning to Quantitate Neutrophil NETosis.
Scientific reports
Nov 15, 2019
We introduce machine learning (ML) to perform classification and quantitation of images of nuclei from human blood neutrophils. Here we assessed the use of convolutional neural networks (CNNs) using free, open source software to accurately quantitate...
Clinical Significance of Circulating Cardiomyocyte-Specific Cell-Free DNA in Patients With Heart Failure: A Proof-of-Concept Study.
The Canadian journal of cardiology
Oct 19, 2019
We investigated clinical significance of cell-free DNA (cfDNA) in heart failure. This study enrolled 32 heart failure patients and 28 control subjects. Total cfDNA levels were not different between groups (P = 0.343). Bisulfite-digital polymerase cha...
Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis.
Nature neuroscience
Jul 25, 2019
Studies of patients afflicted by neurodegenerative diseases suggest that misfolded proteins spread through the brain along anatomically connected networks, prompting progressive decline. Recently, mouse models have recapitulated the cell-to-cell tran...
Synthesis and Evaluation of Biological Activities of Aziridine Derivatives of Urea and Thiourea.
Molecules (Basel, Switzerland)
Dec 25, 2017
In the present paper, we report the synthesis and evaluation of in vitro antimicrobial activities of aziridine-thiourea derivatives. A series of aziridines in reaction with isocyanates and isothiocyanates to obtain urea and thiourea derivatives were ...
Nitric oxide-releasing injectable hydrogels with high antibacterial activity through in situ formation of peroxynitrite.
Acta biomaterialia
Dec 18, 2017
UNLABELLED: Nitric oxide (NO) is an endogenous molecule with many critical biological functions that depend on its concentration. At high levels, NO provides broad-spectrum antibacterial effects through both its pathogen inhibition and killing abilit...
Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles.
Journal of environmental sciences (China)
Nov 7, 2017
As well-known persistent organic pollutants (POPs), organofluorine pollutants such as perfluorooctane sulfonate (PFOS) have been proven to be bioaccumulated and harmful to health. However, toxicological assessment of organofluorinated nanoparticles, ...
Betulin-loaded PEDOT films for regional chemotherapy.
Materials science & engineering. C, Materials for biological applications
Dec 28, 2016
Chemotherapy is one of the most commonly used cancer treatments. Even so, it has significant adverse effects on healthy tissues. These effects can be avoided through the use of regional chemotherapy, an approach based on delivering the anti-cancer ag...
Differential cytotoxicity and internalization of graphene family nanomaterials in myocardial cells.
Materials science & engineering. C, Materials for biological applications
Dec 23, 2016
Given the well-known physical properties of graphene oxide (GO), numerous applications for this novel nanomaterial have been recently envisioned to improve the performance of biomedical devices. However, the toxicological assessment of GO, which stro...
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