OBJECTIVE: Microsatellite instability (MSI) is a novel predictive biomarker for chemotherapy and immunotherapy response, as well as prognostic indicator in colorectal cancer (CRC). The current standard for MSI identification is polymerase chain react...
UNLABELLED: tRNA-derived fragments (tRF) are a class of small noncoding RNAs that have exhibited several functions in cancer. Recent studies have shown that mutations in tRNA genes can lead to global changes in tRF expression levels and may affect tR...
Cancer prevention research (Philadelphia, Pa.)
Sep 2, 2025
UNLABELLED: Higher T-cell infiltration in colorectal tumors has been associated with better prognosis. Evidence indicates that calcium signaling is essential for T-cell functioning. However, as it is unknown whether calcium intake influences T-cell i...
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Sep 1, 2025
BACKGROUND: Chemotherapy-induced adverse drug reactions (ADRs) are common in patients with colorectal cancer. We developed four machine learning models to predict chemotherapy-induced ADRs and assessed the performance. These models leverage high-dime...
BACKGROUND: Background: Fecal volatile organic compound (VOC) analysis has emerged as a promising non-invasive tool for detecting colorectal cancer (CRC). Despite its reported high diagnostic accuracy, clinical adoption is hindered due to issues like...
Colorectal cancer (CRC) is a leading cause of death worldwide. A plethora of research shows the alteration of the gut microbiome and the association of bacterial taxa with CRC. Gaining insights into the health status through microbiome-based diagnosi...
Computer methods and programs in biomedicine
Sep 1, 2025
BACKGROUND AND OBJECTIVE: Colorectal cancer (CRC) ranks among the most prevalent cancers worldwide, with early postoperative recurrence remaining a major cause of mortality. Body composition and inflammatory-nutritional indices (BCINI) have demonstra...
Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related deaths worldwide, with a 5-year survival rate below 20 %. Immunotherapy, particularly immune checkpoint blockade (ICB)-based therapies, has bec...
Studies in health technology and informatics
Aug 7, 2025
Colorectal cancer (CRC), the second deadliest cancer globally, is closely tied to gut microbiota, opening doors for early detection and treatment. This review of 45 studies (2018-2024) highlights microbial biomarkers like Fusobacterium nucleatum, Bac...
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