AI Medical Compendium Topic

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Disease Models, Animal

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Decreased circulating catestatin levels are associated with coronary artery disease: The emerging anti-inflammatory role.

Atherosclerosis Dec 24, 2018
BACKGROUND AND AIMS: The neuropeptide catestatin (CST) is an endogenous nicotinic cholinergic antagonist that acts as pleiotropic cardiac protective hormone. This study investigated the association between CST and coronary artery disease (CAD) and th...
Cells, Cultured Cytokines Biomarkers Female Animals Male Severity of Illness Index Case-Control Studies Disease Models, Animal Human Umbilical Vein Endothelial Cells Peptidyl-Dipeptidase A Down-Regulation Humans Plaque, Atherosclerotic Cell Adhesion Molecules Peptide Fragments Angiotensin-Converting Enzyme 2 Anti-Inflammatory Agents Chromogranin A Coronary Artery Disease Mice, Knockout, ApoE Atherosclerosis
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Degradation of TRPML1 in Neurons Reduces Neuron Survival in Transient Global Cerebral Ischemia.

Oxidative medicine and cellular longevity Dec 18, 2018
Postcardiac arrest syndrome yields poor neurological outcomes, but the mechanisms underlying this condition remain poorly understood. Autophagy plays an important role in neuronal apoptosis induced by ischemia. However, whether autophagy is involved ...
Ischemic Attack, Transient Microtubule-Associated Proteins Quinolines Transient Receptor Potential Channels Astrocytes Autophagy Neurons Phthalimides Mice Cells, Cultured Disease Models, Animal Animals Apoptosis Male Mice, Inbred C57BL Oxidative Stress Reperfusion Injury
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Quantitative ultrasound and machine learning for assessment of steatohepatitis in a rat model.

European radiology Dec 17, 2018
OBJECTIVES: To develop a machine learning model based on quantitative ultrasound (QUS) parameters to improve classification of steatohepatitis with shear wave elastography in rats by using histopathology scoring as the reference standard.
Non-alcoholic Fatty Liver Disease Rats Rats, Sprague-Dawley Disease Models, Animal Liver Machine Learning Animals Male Ultrasonography ROC Curve
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Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-B/p65 Signaling in Chronic Radiculitis Rats.

Pain research & management Dec 13, 2018
BACKGROUND: Oxygen/ozone therapy is a minimally invasive technique for the treatment of radiculitis from lumbar disc herniation. This study aimed at investigating whether intrathecal administration of low-concentration oxygen/ozone could attenuate ch...
Cyclic AMP Cyclic GMP Cyclic Nucleotide Phosphodiesterases, Type 2 Hyperalgesia Transcription Factor RelA Ozone NF-kappa B Radiculopathy Intervertebral Disc Displacement Animals Male Rats, Wistar Rats Signal Transduction Treatment Outcome Disease Models, Animal Oxygen
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High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology.

Nature communications Dec 3, 2018
Technologies for mapping the spatial and temporal patterns of neural activity have advanced our understanding of brain function in both health and disease. An important application of these technologies is the discovery of next-generation neurotherap...
Machine Learning Brain Animals Larva Drug Evaluation, Preclinical Disease Models, Animal Zebrafish Brain Mapping Animals, Genetically Modified Molecular Structure Convulsants Pentylenetetrazole Neuropharmacology Seizures
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A neural network approach to analyze cross-sections of muscle fibers in pathological images.

Computers in biology and medicine Nov 12, 2018
Morphological characteristics of muscle fibers, such as their cross-sections, are important indicators of the health and function of the musculoskeletal system. However, manual analysis of muscle fiber morphology is a labor-intensive and time-consumi...
Neural Networks, Computer Mice Animals Disease Models, Animal Male Muscle Fibers, Skeletal Image Processing, Computer-Assisted Muscular Dystrophies Mice, Inbred mdx
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Placental CD4 T cells isolated from preeclamptic women cause preeclampsia-like symptoms in pregnant nude-athymic rats.

Pregnancy hypertension Nov 2, 2018
Preeclampsia (PE), new onset hypertension during pregnancy, is associated with a proinflammatory profile compared to normal pregnancy (NP). We hypothesize that CD4 T cells from PE patient placentas cause PE symptoms during pregnancy compared to those...
CD4-Positive T-Lymphocytes Humans Vascular Endothelial Growth Factor Receptor-1 Rats Tumor Necrosis Factor-alpha Young Adult Pre-Eclampsia Enzyme-Linked Immunosorbent Assay Pregnancy Adult Arterial Pressure Disease Models, Animal Animals Placentation Female Placenta Real-Time Polymerase Chain Reaction Rats, Nude Interleukin-17
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Seizure forecasting using single robust linear feature as correlation vector of seizure-like events in brain slices preparation in vitro.

Neurological research Oct 17, 2018
Epilepsy is a neurological disorder affecting 50 million individuals globally. Modern research has inspected the likelihood of forecasting epileptic seizures. Algorithmic investigations are giving promising results for seizure prediction. Though most...
Forecasting Animals Rats Support Vector Machine Disease Models, Animal Humans Drug Resistant Epilepsy Electroencephalography Epilepsy Seizures Cerebral Cortex
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Automatic glomerular identification and quantification of histological phenotypes using image analysis and machine learning.

American journal of physiology. Renal physiology Sep 26, 2018
Current methods of scoring histological kidney samples, specifically glomeruli, do not allow for collection of quantitative data in a high-throughput and consistent manner. Neither untrained individuals nor computers are presently capable of identify...
Predictive Value of Tests Biopsy Workflow Kidney Glomerulus Microscopy Rats Disease Models, Animal Mice, Inbred C57BL Kidney Diseases Image Interpretation, Computer-Assisted Pattern Recognition, Automated Species Specificity Mice, Transgenic Humans Machine Learning Software Automation, Laboratory Phenotype Female Reproducibility of Results Animals Male Diagnosis, Computer-Assisted
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Determining optimal ultrasound percent on time with long-pulse torsional phacoemulsification.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie Sep 11, 2018
OBJECTIVE: To evaluate the optimum percent on time for the most efficient lens fragment removal using long-pulse torsional ultrasound (US).
Ultrasonic Therapy Disease Models, Animal Humans Operative Time Animals Cataract Swine High-Energy Shock Waves Time Factors Phacoemulsification
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