AIMC Topic: Disease Models, Animal

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DeepACSON automated segmentation of white matter in 3D electron microscopy.

Communications biology Feb 10, 2021
Tracing the entirety of ultrastructures in large three-dimensional electron microscopy (3D-EM) images of the brain tissue requires automated segmentation techniques. Current segmentation techniques use deep convolutional neural networks (DCNNs) and r...
White Matter Nerve Fibers, Myelinated Mitochondria Image Interpretation, Computer-Assisted Cell Nucleus Microscopy, Electron Reproducibility of Results Animals Male Imaging, Three-Dimensional Rats, Sprague-Dawley Disease Models, Animal Predictive Value of Tests Rats Brain Injuries, Traumatic Artificial Intelligence
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Machine intelligence identifies soluble TNFa as a therapeutic target for spinal cord injury.

Scientific reports Feb 9, 2021
Traumatic spinal cord injury (SCI) produces a complex syndrome that is expressed across multiple endpoints ranging from molecular and cellular changes to functional behavioral deficits. Effective therapeutic strategies for CNS injury are therefore li...
Artificial Intelligence Tumor Necrosis Factor-alpha Female Models, Neurological Injections, Spinal Spinal Cord Injuries Receptors, Tumor Necrosis Factor, Type I Rats, Long-Evans Animals Recombinant Proteins Rats Disease Models, Animal
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Use of Machine Learning to Re-Assess Patterns of Multivariate Functional Recovery after Fluid Percussion Injury: Operation Brain Trauma Therapy.

Journal of neurotrauma Jan 13, 2021
Traumatic brain injury (TBI) is a leading cause of death and disability. Yet, despite immense research efforts, treatment options remain elusive. Translational failures in TBI are often attributed to the heterogeneity of the TBI population and limite...
Machine Learning Recovery of Function Animals Translational Research, Biomedical Rats Datasets as Topic Brain Injuries, Traumatic Disease Models, Animal
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Automated detection of mouse scratching behaviour using convolutional recurrent neural network.

Scientific reports Jan 12, 2021
Scratching is one of the most important behaviours in experimental animals because it can reflect itching and/or psychological stress. Here, we aimed to establish a novel method to detect scratching using deep neural network. Scratching was elicited ...
Neural Networks, Computer Female Animals Mice, Inbred BALB C Pruritus Behavior, Animal Dermatitis, Atopic Male Mice Lysophospholipids Disease Models, Animal
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Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease.

Science (New York, N.Y.) Dec 10, 2020
Mapping the gene-regulatory networks dysregulated in human disease would allow the design of network-correcting therapies that treat the core disease mechanism. However, small molecules are traditionally screened for their effects on one to several o...
Haploinsufficiency Aortic Valve Disease Nitriles Small Molecule Libraries Induced Pluripotent Stem Cells Receptor, Notch1 Mice Disease Models, Animal Mice, Inbred C57BL Calcinosis Drug Evaluation, Preclinical Thiazoles Gene Expression Regulation Aortic Valve Stenosis Aortic Valve Animals Drug Discovery RNA-Seq Gene Regulatory Networks Humans Machine Learning Algorithms
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Impact of chronic intermittent hypoxia on the long non-coding RNA and mRNA expression profiles in myocardial infarction.

Journal of cellular and molecular medicine Nov 20, 2020
Chronic intermittent hypoxia (CIH) is the primary feature of obstructive sleep apnoea (OSA), a crucial risk factor for cardiovascular diseases. Long non-coding RNAs (lncRNAs) in myocardial infarction (MI) pathogenesis have drawn considerable attentio...
Animals Male Echocardiography RNA, Long Noncoding Mice Myocardial Infarction Blotting, Western RNA, Messenger Hypoxia Disease Models, Animal Gene Ontology Mice, Inbred C57BL
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Automatic discovery of clinically interpretable imaging biomarkers for Mycobacterium tuberculosis supersusceptibility using deep learning.

EBioMedicine Nov 7, 2020
BACKGROUND: Identifying which individuals will develop tuberculosis (TB) remains an unresolved problem due to few animal models and computational approaches that effectively address its heterogeneity. To meet these shortcomings, we show that Diversit...
Male Deep Learning Image Processing, Computer-Assisted Computational Biology Mycobacterium tuberculosis Molecular Imaging Immunohistochemistry Disease Models, Animal Tuberculosis Prognosis Humans Female Machine Learning Disease Susceptibility Reproducibility of Results Algorithms Animals Biomarkers
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Deep Learning-Based Segmentation and Quantification in Experimental Kidney Histopathology.

Journal of the American Society of Nephrology : JASN Nov 5, 2020
BACKGROUND: Nephropathologic analyses provide important outcomes-related data in experiments with the animal models that are essential for understanding kidney disease pathophysiology. Precision medicine increases the demand for quantitative, unbiase...
Periodic Acid Mice Kidney Disease Models, Animal Mice, Inbred C57BL Animals Diagnosis, Computer-Assisted Translational Research, Biomedical Kidney Diseases Neural Networks, Computer Male Deep Learning Schiff Bases Kidney Glomerulus Algorithms Pattern Recognition, Automated Image Processing, Computer-Assisted Reproducibility of Results
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Thrombolysis of Pulmonary Emboli via Endobronchial Ultrasound-Guided Transbronchial Needle Injection.

The Annals of thoracic surgery Oct 24, 2020
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle injection (EBUS-TBNI) is a novel technique for treating peribronchial targets. The aim of this study was to evaluate preliminary feasibility of thrombolysis of pulmonary emboli via EBU...
Thrombolytic Therapy Animals Pulmonary Embolism Swine Endoscopic Ultrasound-Guided Fine Needle Aspiration Disease Models, Animal Endosonography Bronchoscopy
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A Comprehensive Analysis of MicroRNAs in Human Osteoporosis.

Frontiers in endocrinology Oct 21, 2020
MicroRNAs (miRNAs) are single-stranded RNA molecules that control gene expression in various processes, such as cancers, Alzheimer's disease, and bone metabolic diseases. However, the regulatory roles of miRNAs in osteoporosis have not been systemati...
Gene Ontology Humans Databases, Genetic Osteoporosis Gene Regulatory Networks Disease Models, Animal Gene Expression Profiling Animals Mice MicroRNAs Protein Interaction Maps Male Computational Biology Hindlimb Suspension
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