AIMC Topic: Disease Models, Animal

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A novel device for studying weight supported, quadrupedal overground locomotion in spinal cord injured rats.

Journal of neuroscience methods Mar 18, 2015
BACKGROUND: Providing weight support facilitates locomotion in spinal cord injured animals. To control weight support, robotic systems have been developed for treadmill stepping and more recently for overground walking.
Disease Models, Animal Robotics Body Weight Psychomotor Performance Locomotion Spinal Cord Injuries Neurological Rehabilitation Canes Female Animals Rats Rats, Sprague-Dawley
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Using trend templates in a neonatal seizure algorithm improves detection of short seizures in a foetal ovine model.

Physiological measurement Feb 5, 2015
Seizures below one minute in duration are difficult to assess correctly using seizure detection algorithms. We aimed to improve neonatal detection algorithm performance for short seizures through the use of trend templates for seizure onset and end. ...
Asphyxia Information Theory Fetal Hypoxia Brain Electroencephalography Animals Seizures Time Factors Signal Processing, Computer-Assisted Support Vector Machine Sheep, Domestic Disease Models, Animal
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Robotic natural orifice transluminal endoscopic surgery (R-NOTES): literature review and prototype system.

Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy Dec 25, 2014
In minimally invasive surgery methods such as laparoscopic surgery, surgical instruments are introduced through small incisions to minimize patient trauma and recovery times. To reduce the number of incisions, new techniques such as natural orifice t...
Natural Orifice Endoscopic Surgery Equipment Safety Humans Systems Analysis Minimally Invasive Surgical Procedures Laparoscopy Animals Equipment Design Swine Robotic Surgical Procedures Disease Models, Animal Robotics
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Innovative application of confocal Raman spectroscopy and Machine learning in cardiovascular diseases identification.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Nov 5, 2025
Myocardial hypertrophy and heart failure are leading causes of mortality in cardiovascular diseases, yet current diagnostic techniques lack the resolution to monitor molecular changes effectively. In this study, we employed confocal Raman spectroscop...
Mice, Inbred C57BL Myocardium Heart Failure Machine Learning Animals Cardiovascular Diseases Male Mice Spectrum Analysis, Raman Disease Models, Animal
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Decoding chronic stress: From behavioral-molecular dynamics in mice to clinical implications of cortisol and IL-17 in depression severity.

Journal of affective disorders Sep 15, 2025
BACKGROUNDS: The etiology of depression involves chronic stress, a recognized determinant of onset and severity. This study adopts a translational approach, utilizing a mouse model and a clinical cohort to explore the relationship between chronic str...
Stress, Psychological Interleukin-17 Mice Disease Models, Animal Male Middle Aged Severity of Illness Index Depression Mice, Inbred C57BL Chronic Disease Hydrocortisone Humans Machine Learning Biomarkers Female Adult Animals
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Call category classification of the isolation-induced ultrasonic vocalizations emitted by BTBR TItpr3/J mouse pups exposed to different perinatal diets.

Brain research Sep 1, 2025
Autism spectrum disorder (ASD) is characterized by deficits in social communication and repetitive behaviors/restricted interests that may be diagnosed as early as 2 years of age. This suggests that the pathology underlying the disorder is present du...
Prenatal Exposure Delayed Effects Vocalization, Animal Mice, Inbred C57BL Diet, High-Fat Social Isolation Animals, Newborn Male Mice Disease Models, Animal Autism Spectrum Disorder Pregnancy Female Animals
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CDKN1A and EGR1 are key genes for endoplasmic reticulum stress-induced ferroptosis in MASH.

Free radical biology & medicine Aug 16, 2025
Metabolic dysfunction-associated steatohepatitis (MASH) is a complex liver disease whose pathogenesis involving endoplasmic reticulum (ER) stress and ferroptosis. However, key regulatory genes remain poorly understood, hindering the development of ef...
Animals Male Mice Fatty Liver Humans Non-alcoholic Fatty Liver Disease Mice, Inbred C57BL Gene Expression Regulation Liver Endoplasmic Reticulum Stress Disease Models, Animal Diet, High-Fat Phenylenediamines Early Growth Response Protein 1 Hep G2 Cells Ferroptosis Cyclin-Dependent Kinase Inhibitor p21
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Mechanistic exploration of hexokinase 2 and metabolism in diabetic cardiomyopathy.

Molecular medicine reports Aug 1, 2025
The pathogenesis of diabetic cardiomyopathy (DCM) remains incompletely understood. The present study employed weighted gene co‑expression network analysis to analyze the DCM transcriptome dataset from the Gene Expression Omnibus (GEO) database to ide...
Diabetic Cardiomyopathies Hexokinase Gene Expression Profiling Transcriptome Mice Disease Models, Animal Humans Animals Male
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The interaction of UBR4, LRP1, and OPHN1 in refractory epilepsy: Drosophila model to investigate the oligogenic effect on epilepsy.

Neurobiology of disease Aug 1, 2025
Refractory epilepsy is an intractable neurological disorder that can be associated with oligogenic/polygenic etiologies. Through trio-based whole-exome sequencing analysis, we identified a clinical case of refractory epilepsy with three candidate gen...
Drosophila Drug Resistant Epilepsy GTPase-Activating Proteins Disease Models, Animal Low Density Lipoprotein Receptor-Related Protein-1 Animals, Genetically Modified Humans Drosophila Proteins Female Ubiquitin-Protein Ligases Animals Male
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Volumetric and Diffusion Tensor Imaging Abnormalities Are Associated With Behavioral Changes Post-Concussion in a Youth Pig Model of Mild Traumatic Brain Injury.

NMR in biomedicine Jul 1, 2025
Mild traumatic brain injury (mTBI) caused by sports-related incidents in children and youth often leads to prolonged cognitive impairments but remains difficult to diagnose. In order to identify clinically relevant imaging and behavioral biomarkers a...
Brain Female Organ Size Behavior, Animal Diffusion Tensor Imaging Animals Brain Concussion Male Swine Disease Models, Animal
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