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Disease Progression

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A machine learning algorithm successfully screens for Parkinson's in web users.

Annals of clinical and translational neurology
OBJECTIVE: To develop, apply, and evaluate, a novel web-based classifier for screening for Parkinson disease among a large cohort of search engine users.

A distributed multitask multimodal approach for the prediction of Alzheimer's disease in a longitudinal study.

NeuroImage
Predicting the progression of Alzheimer's Disease (AD) has been held back for decades due to the lack of sufficient longitudinal data required for the development of novel machine learning algorithms. This study proposes a novel machine learning algo...

Machine learning-based prediction of radiographic progression in patients with axial spondyloarthritis.

Clinical rheumatology
INTRODUCTION: Machine learning is applied to characterize the risk and predict outcomes in multi-dimensional data. The prediction of radiographic progression in axial spondyloarthritis (axSpA) remains limited. Hence, we tested the feasibility of supe...

Atrial fibrillation classification based on convolutional neural networks.

BMC medical informatics and decision making
BACKGROUND: The global age-adjusted mortality rate related to atrial fibrillation (AF) registered a rapid growth in the last four decades, i.e., from 0.8 to 1.6 and 0.9 to 1.7 per 100,000 for men and women during 1990-2010, respectively. In this cont...

The hidden information in patient-reported outcomes and clinician-assessed outcomes: multiple sclerosis as a proof of concept of a machine learning approach.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Machine learning (ML) applied to patient-reported (PROs) and clinical-assessed outcomes (CAOs) could favour a more predictive and personalized medicine. Our aim was to confirm the important role of applying ML to PROs and CAOs of people with relapsin...

Machine learning and bioinformatics models to identify gene expression patterns of ovarian cancer associated with disease progression and mortality.

Journal of biomedical informatics
Ovarian cancer (OC) is a common cause of cancer death among women worldwide, so there is a pressing need to identify factors influencing OC mortality. Much OC patient clinical data is publicly accessible via the Broad Institute Cancer Genome Atlas (T...

Anti-varicella Zoster Virus IgG and hsCRP Levels Correlate with Progression of Coronary Artery Atherosclerosis.

Iranian journal of allergy, asthma, and immunology
The relationship between high levels of anti-Varicella Zoster Virus (VZV) IgG in cerebrospinal fluid (CSF) and cerebrovascular atherosclerosis commends a possible similar association in other vessels. We aimed to investigate the association of VZV-se...

SVM recursive feature elimination analyses of structural brain MRI predicts near-term relapses in patients with clinically isolated syndromes suggestive of multiple sclerosis.

NeuroImage. Clinical
Machine learning classification is an attractive approach to automatically differentiate patients from healthy subjects, and to predict future disease outcomes. A clinically isolated syndrome (CIS) is often the first presentation of multiple sclerosi...

Deep Learning Based on Standard H&E Images of Primary Melanoma Tumors Identifies Patients at Risk for Visceral Recurrence and Death.

Clinical cancer research : an official journal of the American Association for Cancer Research
PURPOSE: Biomarkers for disease-specific survival (DSS) in early-stage melanoma are needed to select patients for adjuvant immunotherapy and accelerate clinical trial design. We present a pathology-based computational method using a deep neural netwo...