In early cancer diagnosis, extracellular vesicles (EVs) are more advantageous than circulating tumor cells due to their smaller size, greater stability, and enhanced tissue penetration. These qualities lead to higher EV concentrations in body fluids,...
Quantum transport-based DNA sequencing is emerging as a promising technique in genetic analysis, offering fast, precise, and scalable decoding of genetic information, holding significant potential for applications in human biology and personalized me...
This study proposes a method for detecting trace quinolone antibiotics in milk using a ternary composite surface-enhanced Raman spectroscopy (SERS) substrate. It combines chemometric algorithms and deep learning models to achieve qualitative and quan...
Allicin tolerance () clusters in phytopathogenic bacteria, which provide resistance to thiosulfinates like allicin, are challenging to find using conventional approaches due to their varied architecture and the paradox of being vertically maintained ...
Bladder cancer is the fourth most common malignant tumor in men, with limited therapeutic biomarkers and heterogeneous responses to immunotherapy. Disulfide bond-driven cell death has emerged as a critical regulator of tumor progression and immune mi...
Laser desorption ionization mass spectrometry (LDI-MS) is a critical platform for high-throughput nontargeted metabolomics analysis in clinical diagnosis. However, traditional organic matrices inherently suffer from background interference in the low...
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder, with oxidative stress recognized as a key pathogenic mechanisms. Oxidative stress disrupts intracellular dynamic- thiol/disulfide homeostasis (DTDH), potentially leading to disu...
Solid-state nanopore and nanochannel biosensors have revolutionized protein detection by offering label-free, highly sensitive analyses. Traditional sensing systems (1st and 2nd stages) primarily focus on inner wall (IW) interactions, facing challeng...
Peptides are an emerging modality for developing therapeutics that can either agonize or antagonize cellular pathways associated with disease, yet peptides often suffer from poor chemical and physical stability, which limits their potential. However,...
Multimodal cancer therapies are often required for progressive cancers due to the high persistence and mortality of the disease and the negative systemic side effects of traditional therapeutic methods. Thus, the development of less invasive modaliti...
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