AIMC Topic: Doxorubicin
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Vitamin D deficiency and supplementation in patients with aggressive B-cell lymphomas treated with immunochemotherapy.
Cancer medicine
Dec 22, 2017
Vitamin D deficiency has been reported to be a negative prognostic factor in elderly patients with aggressive B-cell lymphomas. In vitro data suggest that vitamin D supplementation may enhance rituximab-mediated cytotoxicity. We prospectively assesse...
Enhanced antitumor efficacy of doxorubicin-encapsulated halloysite nanotubes.
International journal of nanomedicine
Dec 19, 2017
To improve the antitumor efficacy of doxorubicin (DOX) and provide novel clinical treatment of gastric cancer, halloysite nanotubes (HNTs) loaded with DOX were encapsulated by soybean phospholipid (LIP) and the formed HNTs/DOX/LIP was systematically ...
Simultaneous delivery of anti-miR21 with doxorubicin prodrug by mimetic lipoprotein nanoparticles for synergistic effect against drug resistance in cancer cells.
International journal of nanomedicine
Dec 30, 2016
The development of drug resistance in cancer cells is one of the major obstacles to achieving effective chemotherapy. We hypothesized that the combination of a doxorubicin (Dox) prodrug and microRNA (miR)21 inhibitor might show synergistic antitumor ...
Optimization of an Anti-poly(ethylene glycol) (anti-PEG) Cell-Based Capture System To Quantify PEG and PEGylated Molecules.
Analytical chemistry
Nov 30, 2016
Sensitive determination of the pharmacokinetics of PEGylated molecules can accelerate the process of drug development. Here, we combined different anti-PEG Fab expressing 293T cells as capture cells (293T/3.3, 293T/6.3, and 293T/15-2b cells) with fou...
Machine learning-based classification of diffuse large B-cell lymphoma patients by eight gene expression profiles.
Cancer medicine
Feb 11, 2016
Gene expression profiling (GEP) had divided the diffuse large B-cell lymphoma (DLBCL) into molecular subgroups: germinal center B-cell like (GCB), activated B-cell like (ABC), and unclassified (UC) subtype. However, this classification with prognosti...
Antibodies, Monoclonal, Murine-Derived
Germinal Center
Cyclophosphamide
Prednisone
Rituximab
Vincristine
Genes, Neoplasm
Male
Middle Aged
Gene Expression Profiling
ROC Curve
Antineoplastic Combined Chemotherapy Protocols
Treatment Outcome
Support Vector Machine
Databases, Genetic
Doxorubicin
Survival Analysis
Prognosis
Female
Aged
Sensitivity and Specificity
Lymphoma, Large B-Cell, Diffuse
Humans
Machine learning-guided fabrication of carbon dot-pepsin nano-conjugates for enhanced bioimaging, synergistic drug delivery, and visible light-induced photosensitization.
Nanoscale
Jun 12, 2025
Carbon dots (CDs) are emerging as next-generation bioimaging agents due to their strong fluorescence, photobleaching resistance, and biocompatibility. However, their small size often limits efficient cell internalization, leading to unspecified cellu...
Active Learning-Based Prediction of Drug Combination Efficacy.
ACS nano
May 13, 2025
Combination therapy, which involves the use of multiple drugs, has emerged as a promising approach to cancer treatment. However, traditional combination therapy development is constrained by the vast experimental design space, requiring exhaustive te...
Machine learning algorithms to control concentrations of carbon nanocomplexes in a biological medium via optical absorption spectroscopy: how to choose and what to expect?
Applied optics
Sep 20, 2021
A solution of spectroscopic inverse problems, implying determination of target parameters of the research object via analysis of spectra of various origins, is an overly complex task, especially in case of strong variability of the research object. O...
Dual-responsive biohybrid neutrobots for active target delivery.
Science robotics
Mar 24, 2021
Swimming biohybrid microsized robots (e.g., bacteria- or sperm-driven microrobots) with self-propelling and navigating capabilities have become an exciting field of research, thanks to their controllable locomotion in hard-to-reach areas of the body ...
Kidney dysfunction and oxidative stress in doxorubicin-induced nephrotic rat: Protective role of sesame oil.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
Jan 1, 2021
Doxorubicin (DOX) is an antineoplastic agent which it's clinical use has been limited due to its major side effects including cardiotoxicity and nephrotic syndrome. Sesame oil (SO) is an important edible oil with many pharmacologic effects. The aim o...
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