AIMC Topic: Drug Monitoring

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Machine Learning-based Prediction Model for Treatment of Acromegaly With First-generation Somatostatin Receptor Ligands.

The Journal of clinical endocrinology and metabolism Jun 16, 2021
CONTEXT: Artificial intelligence (AI), in particular machine learning (ML), may be used to deeply analyze biomarkers of response to first-generation somatostatin receptor ligands (fg-SRLs) in the treatment of acromegaly.
Female Aged Young Adult Adult Male Middle Aged Humans Machine Learning Biomarkers Drug Monitoring Ligands Acromegaly Keratins Clinical Decision Rules Receptors, Somatostatin Human Growth Hormone Insulin-Like Growth Factor I Logistic Models Treatment Outcome Predictive Value of Tests
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New artificial intelligence prediction model using serial prothrombin time international normalized ratio measurements in atrial fibrillation patients on vitamin K antagonists: GARFIELD-AF.

European heart journal. Cardiovascular pharmacotherapy Sep 1, 2020
AIMS: Most clinical risk stratification models are based on measurement at a single time-point rather than serial measurements. Artificial intelligence (AI) is able to predict one-dimensional outcomes from multi-dimensional datasets. Using data from ...
Humans Neural Networks, Computer Prothrombin Time Drug Therapy, Computer-Assisted Predictive Value of Tests Anticoagulants Databases, Factual Blood Coagulation Prospective Studies International Normalized Ratio Aged Registries Female Drug Monitoring Stroke Aged, 80 and over Reproducibility of Results Administration, Oral Male Risk Factors Atrial Fibrillation Risk Assessment Vitamin K Time Factors Hemorrhage Treatment Outcome
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Super learner analysis of real-time electronically monitored adherence to antiretroviral therapy under constrained optimization and comparison to non-differentiated care approaches for persons living with HIV in rural Uganda.

Journal of the International AIDS Society Mar 1, 2020
INTRODUCTION: Real-time electronic adherence monitoring (EAM) systems could inform on-going risk assessment for HIV viraemia and be used to personalize viral load testing schedules. We evaluated the potential of real-time EAM (transferred via cellula...
Machine Learning Female Adult Male HIV Infections Viral Load Humans Drug Monitoring CD4 Lymphocyte Count Viremia HIV-1 Anti-HIV Agents Cohort Studies Medication Adherence Uganda Longitudinal Studies
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Deep Learning Approach for Assessment of Bladder Cancer Treatment Response.

Tomography (Ann Arbor, Mich.) Mar 1, 2019
We compared the performance of different Deep learning-convolutional neural network (DL-CNN) models for bladder cancer treatment response assessment based on transfer learning by freezing different DL-CNN layers and varying the DL-CNN structure. Pre-...
Radiographic Image Interpretation, Computer-Assisted Cystectomy Urography Transfer, Psychology Humans Tomography, X-Ray Computed Sensitivity and Specificity Antineoplastic Agents Deep Learning ROC Curve Decision Support Systems, Clinical Treatment Outcome Neoadjuvant Therapy Urinary Bladder Neoplasms Drug Monitoring
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Pharmacokinetic Therapeutic Drug Monitoring of Advagraf in More Than 500 Adult Renal Transplant Patients, Using an Expert System Online.

Therapeutic drug monitoring Jun 1, 2018
BACKGROUND: Immunosuppressant Bayesian dose adjustment (ISBA) is an online expert system, routinely used by approximately 140 transplantation centers in the world for the dose adjustment of immunosuppressive drugs in transplant patients. This system ...
Immunosuppressive Agents Area Under Curve Drug Monitoring Internet Kidney Transplantation Tacrolimus Humans Expert Systems Retrospective Studies Female Adult Male
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THE EFFECT OF TOTAL AND PARTIAL NEPHRECTOMY ON THE PHARMACOKINETICS OF INTRAVENOUS PARACETAMOL IN HUMANS.

Acta poloniae pharmaceutica May 1, 2017
Paracetamol is one of the most common analgesic and antipyretic drugs. Recently intravenous paracetamol has been widely used to treat moderate postoperative pain. Surgery is the main method of treatment of renal cancer. Total or partial nephrectomy c...
Humans Female Aged Aged, 80 and over Adult Male Middle Aged Kidney Infusions, Intravenous Area Under Curve Drug Monitoring Half-Life Nephrectomy Models, Biological Renal Elimination Kidney Neoplasms Antipyretics Metabolic Clearance Rate Chromatography, High Pressure Liquid Spectrophotometry, Ultraviolet Biological Availability Acetaminophen Analgesics, Non-Narcotic
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DEVELOPMENT AND VALIDATION OF FAST REVERSED-PHASE HPLC METHOD FOR ANALYSIS OF ESOMEPRAZOLE IN RABBIT PLASMA.

Acta poloniae pharmaceutica Mar 1, 2017
The present study focused to develop rapid, accurate and sensitive reversed-phase high pressure liquid chromatography method for the quantification of esomeprazole (ESO) magnesium in rabbit plasma. Chromatographic separation was achieved isocraticall...
Drug Stability Rabbits Freezing Reproducibility of Results Linear Models Hydrogen-Ion Concentration Hydroxides Animals Chromatography, High Pressure Liquid Buffers Proton Pump Inhibitors Limit of Detection Acetonitriles Chromatography, Reverse-Phase Esomeprazole Drug Monitoring Solvents Potassium Compounds Cold Temperature Methanol Spectrophotometry, Ultraviolet
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REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR DETERMINATION OF 5-FLUOROURACIL IN RABBIT PLASMA.

Acta poloniae pharmaceutica Mar 1, 2017
A simple, efficient, accurate and selective HPLC method has been developed and validated successfully for the estimation of 5-fluorouracil in rabbit plasma. The drug was eluted by using Supelco C18 column (1.5 cm x 4.6 mm, 5 μm) with a mobile phase c...
Methanol Rabbits Hydrogen-Ion Concentration Fluorouracil Antimetabolites, Antineoplastic Reproducibility of Results Linear Models Perchlorates Chromatography, High Pressure Liquid Buffers Animals Solvents Chromatography, Reverse-Phase Water Calibration Limit of Detection Reference Standards Drug Monitoring
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Therapeutic Drug Monitoring of Phenytoin by Simple, Rapid, Accurate, Highly Sensitive and Novel Method and Its Clinical Applications.

Current pharmaceutical biotechnology Jan 1, 2017
BACKGROUND: Phenytoin has very challenging pharmacokinetic properties. To prevent its toxicity and ensure efficacy, continuous therapeutic monitoring is required. It is hard to get a simple, accurate, rapid, easily available, economical and highly se...
Phenytoin Child Chromatography, Liquid Epilepsy Drug Monitoring Anticonvulsants Tandem Mass Spectrometry Adult Male Humans Middle Aged Female Adolescent Aged Child, Preschool Young Adult
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Adverse Drug Event Monitoring with Clinical and Laboratory Data Using Arden Syntax.

Studies in health technology and informatics Jan 1, 2017
In times of steadily increasing numbers of administered drugs, the detection of adverse drug events (ADEs) is an important aspect of improving patient safety. At present only about 1-13% of detected ADEs are reported. Raising the number of reported A...
Humans Patient Safety Drug Monitoring Drug-Related Side Effects and Adverse Reactions Knowledge Bases Pharmacovigilance Adverse Drug Reaction Reporting Systems Hyperkalemia
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