AIMC Topic: Drug Monitoring

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Non-weight-based enoxaparin dosing subtherapeutic in trauma patients.

The Journal of surgical research
BACKGROUND: We report our experience dosing and monitoring enoxaparin with anti-factor Xa activity (anti-FXaA) levels for venous thromboembolism prophylaxis in trauma patients (TP).

SERS based determination of ceftriaxone, ampicillin, and vancomycin in serum using WS/Au@Ag nanocomposites and a 2D-CNN regression model.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Accurate therapeutic drug monitoring (TDM) of antibiotics including ceftriaxone, ampicillin, and vancomycin plays an important role in the treatment of neonatal sepsis, a common and life-threatening disease in neonates. A highly sensitive surface-enh...

Prediction of Vancomycin-Associated Nephrotoxicity Based on the Area under the Concentration-Time Curve of Vancomycin: A Machine Learning Analysis.

Biological & pharmaceutical bulletin
Several machine learning models have been proposed to predict vancomycin (VCM)-associated nephrotoxicity; however, they have notable limitations. Specifically, they do not use the area under the concentration-time curve (AUC) as recommended in the la...

Critical Appraisal on the Role of Warfarin in the Current Era.

The Journal of the Association of Physicians of India
Warfarin has been the most extensively used oral anticoagulant (OAC) in medical settings for over 60 years. Its uses, potential adverse effects, and methods for reversing its effects have been firmly established, rendering it a routine medication in ...

Machine Learning-based Prediction Model for Treatment of Acromegaly With First-generation Somatostatin Receptor Ligands.

The Journal of clinical endocrinology and metabolism
CONTEXT: Artificial intelligence (AI), in particular machine learning (ML), may be used to deeply analyze biomarkers of response to first-generation somatostatin receptor ligands (fg-SRLs) in the treatment of acromegaly.

Super learner analysis of real-time electronically monitored adherence to antiretroviral therapy under constrained optimization and comparison to non-differentiated care approaches for persons living with HIV in rural Uganda.

Journal of the International AIDS Society
INTRODUCTION: Real-time electronic adherence monitoring (EAM) systems could inform on-going risk assessment for HIV viraemia and be used to personalize viral load testing schedules. We evaluated the potential of real-time EAM (transferred via cellula...

Deep Learning Approach for Assessment of Bladder Cancer Treatment Response.

Tomography (Ann Arbor, Mich.)
We compared the performance of different Deep learning-convolutional neural network (DL-CNN) models for bladder cancer treatment response assessment based on transfer learning by freezing different DL-CNN layers and varying the DL-CNN structure. Pre-...

Pharmacokinetic Therapeutic Drug Monitoring of Advagraf in More Than 500 Adult Renal Transplant Patients, Using an Expert System Online.

Therapeutic drug monitoring
BACKGROUND: Immunosuppressant Bayesian dose adjustment (ISBA) is an online expert system, routinely used by approximately 140 transplantation centers in the world for the dose adjustment of immunosuppressive drugs in transplant patients. This system ...