AIMC Topic: Dysbiosis

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Gut microbiota in rheumatoid arthritis: Mechanistic insights, clinical biomarkers, and translational perspectives.

Autoimmunity reviews
Rheumatoid arthritis (RA) is a systemic autoimmune disease shaped by complex interactions between genetics and environmental factors, among which gut microbiota has emerged as a critical modulator. Recent advances have implicated gut microbiota dysbi...

Gut microbiota and SCFAs improve the treatment efficacy of chemotherapy and immunotherapy in NSCLC.

NPJ biofilms and microbiomes
The role of gut dysbiosis in shaping immunotherapy responses is well-recognized, yet its effect on the therapeutic efficacy of chemotherapy and immunotherapy combinations remains poorly understood. We analyzed gut microbiota in non-small cell lung ca...

Oral and Gut Dysbiosis in Migraine: Oral Microbial Signatures as Biomarkers of Migraine.

Neurology(R) neuroimmunology & neuroinflammation
BACKGROUND AND OBJECTIVES: Emerging evidence suggests that oral health conditions may exacerbate migraine, and saliva is a potential source of biomarkers for migraine. The 3-way interaction of the oral-gut-brain axis has been implicated in several ne...

Gut microbiota alterations are linked to COVID-19 severity in North African and European populations.

NPJ biofilms and microbiomes
Although COVID-19 primarily affects the respiratory system, many patients experience gastrointestinal symptoms, suggesting a role for the gut microbiota in disease pathogenesis. To explore this, we performed shotgun metagenomic sequencing on stool sa...

Insight into microbial extracellular vesicles as key communication materials and their clinical implications for lung cancer (Review).

International journal of molecular medicine
The complexity of lung cancer, driven by multifactorial causes such as genetic, environmental and lifestyle factors, underscores the necessity for tailored treatment strategies informed by recent advancements. Studies highlight a significant associat...

Machine learning based gut microbiota pattern and response to fiber as a diagnostic tool for chronic inflammatory diseases.

BMC microbiology
Gut microbiota has been implicated in the pathogenesis of multiple gastrointestinal (GI) and systemic metabolic and inflammatory disorders where disrupted gut microbiota composition and function (dysbiosis) has been found in multiple studies. Thus, h...

Microbiome and fragmentation pattern of blood cell-free DNA and fecal metagenome enhance colorectal cancer micro-dysbiosis and diagnosis analysis: a proof-of-concept study.

mSystems
Colorectal cancer (CRC) is the third most common cancer, and it can be prevented by performing early screening. As a hallmark of cancer, the human microbiome plays important roles in the occurrence and development of CRC. Recently, the blood microbio...

Single-cell microbiota phenotyping reveals distinct disease and therapy-associated signatures in Crohn's disease.

Gut microbes
IgA-coated fractions of the intestinal microbiota of Crohn's disease (CD) patients have been shown to contain taxa that hallmark the compositional dysbiosis in CD microbiomes. However, the correlation between other cellular properties of intestinal b...

Gut microbial composition associated with risk of premature aging in women with Yin-deficiency constitution.

Frontiers in cellular and infection microbiology
BACKGROUND: Yin-deficiency constitution (YinDC) refers to a traditional Chinese medicine concept, characterized by an imbalance state that includes an imbalance in the gut microbiota, resulting from a relative deficiency of Yin fluids within the body...