AIMC Topic: Epithelial Cells

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Hyperplastic growth, not hydrostatic distension, in endolymphatic hydrops in humans challenges the classic view of Meniere's disease.

Scientific reports
Meniere's disease (MD), a degenerative inner ear disorder, is characterized by debilitating episodic vertigo and hearing fluctuations, progressing to permanent sensory impairment. The prevailing dogma attributes these symptoms to abnormal inner ear f...

Linarin protects against asthma-induced airway epithelial ferroptosis and inflammation via ALDH2 regulation.

Phytomedicine : international journal of phytotherapy and phytopharmacology
BACKGROUND: Asthma, a complex disease characterized by airway epithelial dysfunction and chronic inflammation, poses ongoing therapeutic challenges.

Recellularization of scaffolds derived from precision-cut kidney slices.

Biomedical materials (Bristol, England)
The global rise in chronic kidney disease necessitates innovative solutions for end-stage renal disease that can help to overcome the limitations of the only available treatment options, transplantation and dialysis. Tissue engineering presents a pro...

FAM46B inhibits CS-induced oxidative stress and ferroptosis in bronchial epithelial cells via KLHL24.

International immunopharmacology
BACKGROUND: Chronic obstructive pulmonary disease (COPD), mainly caused by cigarette smoke (CS), is a global health concern. Ferroptosis is recognized as a key driver of COPD progression, yet its underlying mechanisms are unclear. This study aimed to...

Immunohistochemistry guided segmentation of benign epithelial cells, in situ lesions, and invasive epithelial cells in breast cancer slides.

PloS one
Digital pathology enables automatic analysis of histopathological sections using artificial intelligence. Automatic evaluation could improve diagnostic efficiency and find associations between morphological features and clinical outcome. For developm...

Multimodal feature fusion machine learning for predicting chronic injury induced by engineered nanomaterials.

Nature communications
Concerns regarding chronic injuries (e.g., fibrosis and carcinogenesis) induced by nanoparticles raised public health concerns and need to be rapidly assessed in hazard identification. Although in silico analysis is commonly used for risk assessment ...

The Role of Autophagy and Cell Communication in COPD Progression: Insights from Bioinformatics and scRNA-seq.

COPD
Chronic obstructive pulmonary disease (COPD) is characterized by restricted airflow that leads to significant respiratory difficulties. This progressive disease often results in diminished pulmonary function and the onset of additional respiratory co...

Detection of Human Bladder Epithelial Cancerous Cells with Atomic Force Microscopy and Machine Learning.

Cells
The development of noninvasive methods for bladder cancer identification remains a critical clinical need. Recent studies have shown that atomic force microscopy (AFM), combined with pattern recognition machine learning, can detect bladder cancer by ...

Preparation, characterization, and protective effects of carbon dots against oxidative damage induced by LPS in IPEC-J2 cells.

Frontiers in cellular and infection microbiology
This study aimed to prepare carbon dots (GF-CDs) and examine their efficacy in mitigating oxidative stress and apoptosis in intestinal porcine epithelial cells from the jejunum (IPEC-J2 cells) induced by lipopolysaccharide (LPS). The GF-CDs were syn...