AIMC Topic: Humans

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DeepM6ASeq: prediction and characterization of m6A-containing sequences using deep learning.

BMC bioinformatics
BACKGROUND: N6-methyladensine (m6A) is a common and abundant RNA methylation modification found in various species. As a type of post-transcriptional methylation, m6A plays an important role in diverse RNA activities such as alternative splicing, an ...

Identification of pre-microRNAs by characterizing their sequence order evolution information and secondary structure graphs.

BMC bioinformatics
BACKGROUND: Distinction between pre-microRNAs (precursor microRNAs) and length-similar pseudo pre-microRNAs can reveal more about the regulatory mechanism of RNA biological processes. Machine learning techniques have been widely applied to deal with ...

Better medicine through machine learning: What's real, and what's artificial?

PLoS medicine
Machine Learning Special Issue Guest Editors Suchi Saria, Atul Butte, and Aziz Sheikh cut through the hyperbole with an accessible and accurate portrayal of the forefront of machine learning in clinical translation.

Learning from data to predict future symptoms of oncology patients.

PloS one
Effective symptom management is a critical component of cancer treatment. Computational tools that predict the course and severity of these symptoms have the potential to assist oncology clinicians to personalize the patient's treatment regimen more ...
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Rapid microarray-based assay for detection of pyrazinamide resistant Mycobacterium tuberculosis.

Diagnostic microbiology and infectious disease
Pyrazinamide (PZA) is a key antibiotic for the treatment of drug susceptible tuberculosis. PZA-resistance is mainly mediated by mutations in the pncA gene; however the current gold standard is a phenotypic drug susceptibility test requiring a well-ad...

Association between prenatal exposure to multiple persistent organic pollutants (POPs) and growth indicators in newborns.

Environmental research
Despite the fact that many of persistent organic pollutants (POPs) have been banned for decades, they still constitute a group of harmful substances to human health. Prenatal exposure can have adverse effects on one's health as well as on their newbo...

Renal Function Impairment in Kidney Transplantation: Importance of Early BK Virus Detection.

Transplantation proceedings
BACKGROUND: BK virus allograft nephropathy is a major complication of kidney transplantation that markedly reduces graft survival (50% graft failure 24 months after being diagnosed). BK virus replication can occur at any time posttransplantation. Vir...
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Ultrasonic Tethering to Enable Side-by-Side Following for Powered Wheelchairs.

Sensors (Basel, Switzerland)
In social situations, people who use a powered wheelchair must divide their attention between navigating the chair and conversing with people. These conversations could lead to increased mental stress when navigating and distraction from maneuvering ...

In vitro bioactivity and degradation behaviour of β-wollastonite derived from natural waste.

Materials science & engineering. C, Materials for biological applications
Calcium silicate ceramics, in particular wollastonite (CaSiO), is the most commonly used bioactive material for bone regeneration and repairing applications. The present study aims to synthesize cost effective wollastonite using natural waste materia...

Predictors of Nodal and Metastatic Failure in Early Stage Non-small-cell Lung Cancer After Stereotactic Body Radiation Therapy.

Clinical lung cancer
INTRODUCTION/BACKGROUND: Many patients with early stage non-small-cell lung cancer (ES-NSCLC) undergoing stereotactic body radiation therapy (SBRT) develop metastases, which is associated with poor outcomes. We sought to identify factors predictive o...