AIMC Topic: Humans

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Development and Validation of a Lifestyle-Based 10-Year Risk Prediction Model of Colorectal Cancer for Early Stratification: Evidence from a Longitudinal Screening Cohort in China.

Nutrients
Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, with growing evidence linking risk to lifestyle and dietary factors. However, nutrition-related exposures have rarely been integrated into existing CRC ...

Comparison of salivary statherin and beta-defensin-2 levels, oral health behaviors, and demographic factors in children with and without early childhood caries.

BMC oral health
BACKGROUND: Early childhood caries (ECC) is a widespread pediatric dental condition that is influenced by a combination of biological, behavioral, and demographic factors. Salivary biomarkers, including beta-defensin-2 (BD-2) and statherin (STATH), o...

TRAF3 as a potential diagnostic biomarker for recurrent pregnancy loss: insights from single-cell transcriptomics and machine learning.

BMC pregnancy and childbirth
BACKGROUND: Recurrent pregnancy loss (RPL), characterized by multiple miscarriages, remains a condition with unclear etiology, posing significant challenges for affected women and couples. This study aims to explore the underlying mechanisms of RPL, ...

Estimating motor symptom presence and severity in Parkinson's disease from wrist accelerometer time series using ROCKET and InceptionTime.

Scientific reports
Parkinson's disease (PD) is a neurodegenerative condition characterized by frequently changing motor symptoms, necessitating continuous symptom monitoring for more targeted treatment. Classical time series classification and deep learning techniques ...

Exploration of the potential therapeutic effects and targets of Coriandrum sativum on non-erosive esophagitis based on bioinformatics and molecular dynamics simulation.

Scientific reports
Gastroesophageal reflux disease (GERD) is one of the most frequently diagnosed gastrointestinal disorders, adversely affecting quality of life. Coriandrum sativum has been shown to effectively promote gastrointestinal motility, alleviate gastric disc...

Incorporating the STOP-BANG questionnaire improves prediction of cardiovascular events during hospitalization after myocardial infarction.

Scientific reports
Obstructive sleep apnea (OSA) may impact outcomes in acute coronary syndrome (ACS) patients. The Global Registry of Acute Coronary Events (GRACE) score assesses cardiovascular risk post-ACS. This study evaluated whether incorporating the STOP-BANG sc...

NeoPred: dual-phase CT AI forecasts pathologic response to neoadjuvant chemo-immunotherapy in NSCLC.

Journal for immunotherapy of cancer
BACKGROUND: Accurate preoperative prediction of major pathological response or pathological complete response after neoadjuvant chemo-immunotherapy remains a critical unmet need in resectable non-small-cell lung cancer (NSCLC). Conventional size-base...

Performance of GPT-4 in oral and maxillofacial surgery board exams: challenges in specialized questions.

Oral and maxillofacial surgery
PURPOSE: The aim of this study was to evaluate the performance of GPT-4 in answering oral and maxillofacial surgery (OMFS) board exam questions, given its success in other medical specializations.

Large Language Models in Medicine: Applications, Challenges, and Future Directions.

International journal of medical sciences
In recent years, large language models (LLMs) represented by GPT-4 have developed rapidly and performed well in various natural language processing tasks, showing great potential and transformative impact. The medical field, due to its vast data info...

Development Of the VAMPCT Score for Predicting Mortality in CKD Patients with COVID-19.

International journal of medical sciences
Chronic kidney disease (CKD) patients with coronavirus disease 2019 (COVID-19) are at significant risk of death. However, clinical identification of high-risk individuals remains suboptimal despite the recognition of many pathophysiological and como...