AIMC Topic: Kidney Diseases
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Pharmacokinetics and Safety of Elotuzumab Combined With Lenalidomide and Dexamethasone in Patients With Multiple Myeloma and Various Levels of Renal Impairment: Results of a Phase Ib Study.
Clinical lymphoma, myeloma & leukemia
Dec 21, 2015
INTRODUCTION: The present study evaluated the pharmacokinetics and safety of elotuzumab, a humanized IgG1 monoclonal antibody against signaling lymphocyte activation molecule-F7, combined with lenalidomide and dexamethasone, in patients with multiple...
Treatment Outcome
Kidney Function Tests
Antibodies, Monoclonal, Humanized
Kidney Diseases
Thalidomide
Neoplasm Staging
Dexamethasone
Multiple Myeloma
Male
Middle Aged
Humans
Severity of Illness Index
Antineoplastic Combined Chemotherapy Protocols
Female
Aged
Aged, 80 and over
Adult
Lenalidomide
Cytogenetic Analysis
Retreatment
Impact of renal impairment on platelet reactivity and clinical outcomes during chronic dual antiplatelet therapy following coronary stenting.
European heart journal. Cardiovascular pharmacotherapy
Dec 17, 2015
AIMS: Clinical utilization of dual antiplatelet therapy (DAPT) in patients with renal impairment (RI) following percutaneous coronary interventions (PCI) represents an urgent, unmet need choosing optimal agents, duration of treatment, and potential d...
A Soft Computing Approach to Kidney Diseases Evaluation.
Journal of medical systems
Aug 27, 2015
Kidney renal failure means that one's kidney have unexpectedly stopped functioning, i.e., once chronic disease is exposed, the presence or degree of kidney dysfunction and its progression must be assessed, and the underlying syndrome has to be diagno...
Robot-assisted laparoscopic management of duplex renal anomaly: Comparison of surgical outcomes to traditional pure laparoscopic and open surgery.
Journal of pediatric urology
Aug 17, 2015
INTRODUCTION: Surgical management of duplex renal anomaly (DRA) is complex because of individual anatomic variation, competing priorities of vesicoureteral reflux (VUR) and ureteral obstruction present in the same child, the varied differential funct...
Lack of association between anemia and renal disease progression in Chinese patients with type 2 diabetes.
Journal of diabetes investigation
Jun 3, 2015
AIMS/INTRODUCTION: Anemia has a close interaction with renal dysfunction in diabetes patients. More proof is still awaited on the relationship between anemia and the progression of renal disease in this population.
Comparing the efficacy and safety between robotic-assisted versus open pyeloplasty in children: a systemic review and meta-analysis.
World journal of urology
Mar 10, 2015
OBJECTIVE: This manuscript is mainly to systemically review the published reports that compared the efficacy and safety of robotic-assisted (RP) versus open pyeloplasty (OP) in children with ureteropelvic junction obstruction (UPJO).
PhenoMiner: a quantitative phenotype database for the laboratory rat, Rattus norvegicus. Application in hypertension and renal disease.
Database : the journal of biological databases and curation
Jan 28, 2015
Rats have been used extensively as animal models to study physiological and pathological processes involved in human diseases. Numerous rat strains have been selectively bred for certain biological traits related to specific medical interests. Recent...
Applying exposure-response analysis to enhance Mycophenolate Mofetil dosing precision in pediatric patients with immune-mediated renal diseases by machine learning models.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Aug 1, 2025
BACKGROUND: Mycophenolate mofetil (MMF), a cornerstone immunosuppressant for lupus nephritis, is increasingly used off-label in pediatric immune-mediated renal diseases. The aims of this study were to develop and validate pharmacokinetic models for m...
AI-driven glomerular morphology quantification: a novel pipeline for assessing basement membrane thickness and podocyte foot process effacement in kidney diseases.
Computer methods and programs in biomedicine
Aug 1, 2025
BACKGROUND AND OBJECTIVE: Measuring the thickness of the glomerular basement membrane (GBM) and assessing the percentage of podocyte foot process effacement (%PFPE) are important for diagnosing non-neoplastic kidney diseases. However, when performed ...
Molecule-Responsive SERS Sensors for Urine Diagnosis of Kidney Diseases Enhanced by Neural Networks.
Analytical chemistry
Jul 1, 2025
Early diagnosis of kidney disease is crucial for treatment and prognosis. Compared with kidney biopsy, a noninvasive urine-based diagnosis method of kidney disease can be more convenient and less painful for patients. Urine is closely associated with...
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