Genomic heterogeneity has largely been overlooked in single-cell replication timing (scRT) studies. Here, we develop MnM, an efficient machine learning-based tool that allows disentangling scRT profiles from heterogenous samples. We use single-cell c...
OBJECTIVES: Alzheimer's disease (AD) poses a significant challenge for individuals aged 65 and older, being the most prevalent form of dementia. Although existing AD risk prediction tools demonstrate high accuracy, their complexity and limited access...
Timelapse microscopy has recently been employed to study the metabolism and physiology of cyanobacteria at the single-cell level. However, the identification of individual cells in brightfield images remains a significant challenge. Traditional inten...
BACKGROUND: Immunoglobulin A nephropathy (IgAN) has a heterogeneous clinical presentation. Comparison of different IgAN subgroups may facilitate the application of more targeted therapies. This study was aimed to distinct disease phenotypes in IgAN a...
Microplastics (MPs) can adsorb antibiotics (ATs) to cause combined pollution in the environment. Research on this topic has been limited to specific types of MPs and ATs, resulting in inconsistent findings, particularly for the influencing factors an...
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Feb 7, 2025
Primary graft dysfunction (PGD) is a common complication after lung transplantation associated with poor outcomes. Although risk factors have been identified, the complex interactions between clinical variables affecting PGD risk are not well underst...
Journal of clinical monitoring and computing
Feb 7, 2025
Regional cerebral oxygen saturation (rSO) is used to monitor cerebral perfusion with emerging evidence that optimization of rSO may improve neurological and non-neurological outcomes. To manipulate rSO an understanding of the variables that drive its...
Computer methods and programs in biomedicine
Feb 7, 2025
BACKGROUND AND OBJECTIVE: Integrating multimodal data, such as pathology images and genomics, is crucial for understanding cancer heterogeneity, personalized treatment complexity, and enhancing survival prediction. However, most current prognostic me...
RATIONALE AND OBJECTIVES: To develop and validate a computed tomography-based radiomics nomogram for cancer-specific survival (CSS) prediction in curatively resected colorectal cancer (CRC), and its performance was compared with the American Joint Co...
BACKGROUND: Safety signals for potential drug-induced adverse events (AEs) typically emerge from multiple data sources, primarily spontaneous reporting systems, despite known limitations. Increasingly, real-world data from sources such as electronic ...
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