AIMC Topic: Macrophages
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Biohybrid microrobots regulate colonic cytokines and the epithelium barrier in inflammatory bowel disease.
Science robotics
Jun 26, 2024
Cytokines have been identified as key contributors to the development of inflammatory bowel disease (IBD), yet conventional treatments often prove inadequate and carry substantial side effects. Here, we present an innovative biohybrid robotic system,...
Immune Cell-Based Microrobots for Remote Magnetic Actuation, Antitumor Activity, and Medical Imaging.
Advanced healthcare materials
Jun 25, 2024
Translating medical microrobots into clinics requires tracking, localization, and performing assigned medical tasks at target locations, which can only happen when appropriate design, actuation mechanisms, and medical imaging systems are integrated i...
Integrated analysis of single-cell sequencing and machine learning identifies a signature based on monocyte/macrophage hub genes to analyze the intracranial aneurysm associated immune microenvironment.
Frontiers in immunology
Jun 24, 2024
Monocytes are pivotal immune cells in eliciting specific immune responses and can exert a significant impact on the progression, prognosis, and immunotherapy of intracranial aneurysms (IAs). The objective of this study was to identify monocyte/macrop...
IPF-related new macrophage subpopulations and diagnostic biomarker identification - combine machine learning with single-cell analysis.
Respiratory research
Jun 13, 2024
Idiopathic pulmonary fibrosis (IPF) is a chronic disease of unknown etiology that lacks a specific treatment. In IPF, macrophages play a key regulatory role as a major component of the lung immune system, especially during inflammation and fibrosis. ...
Integrating machine learning algorithms and single-cell analysis to identify gut microbiota-related macrophage biomarkers in atherosclerotic plaques.
Frontiers in cellular and infection microbiology
Apr 23, 2024
OBJECTIVE: The relationship between macrophages and the gut microbiota in patients with atherosclerosis remains poorly defined, and effective biological markers are lacking. This study aims to elucidate the interplay between gut microbial communities...
Receptors, CCR1
CD68 Molecule
Humans
Biomarkers
Machine Learning
Gene Expression Profiling
Single-Cell Analysis
Algorithms
Gene Regulatory Networks
Macrophages
Gastrointestinal Microbiome
Antigens, CD
Atherosclerosis
Antigens, Differentiation, Myelomonocytic
Plaque, Atherosclerotic
Interferon Regulatory Factors
Agammaglobulinaemia Tyrosine Kinase
PROS1 is a crucial gene in the macrophage efferocytosis of diabetic foot ulcers: a concerted analytical approach through the prisms of computer analysis.
Aging
Apr 10, 2024
BACKGROUND: Diabetic foot ulcers (DFUs) pose a serious long-term threat because of elevated mortality and disability risks. Research on its biomarkers is still, however, very limited. In this paper, we have effectively identified biomarkers linked wi...
A multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer.
Cell reports. Medicine
Feb 1, 2024
Colorectal cancer (CRC) is a common malignancy involving multiple cellular components. The CRC tumor microenvironment (TME) has been characterized well at single-cell resolution. However, a spatial interaction map of the CRC TME is still elusive. Her...
Prediction of six macrophage phenotypes and their IL-10 content based on single-cell morphology using artificial intelligence.
Frontiers in immunology
Jan 4, 2024
INTRODUCTION: The last decade has led to rapid developments and increased usage of computational tools at the single-cell level. However, our knowledge remains limited in how extracellular cues alter quantitative macrophage morphology and how such mo...
Pepsin Hydrolysate from Surimi Industry-Related Olive Flounder Head Byproducts Attenuates LPS-Induced Inflammation and Oxidative Stress in RAW 264.7 Macrophages and In Vivo Zebrafish Model.
Marine drugs
Dec 28, 2023
Fish head byproducts derived from surimi processing contribute about 15% of the total body weight, which are beneficial to health because they contain essential nutrients. In this study, olive flounder (OF) was the target species in order to maximize...
Identifying Macrophage-Related Genes in Ulcerative Colitis Using Weighted Coexpression Network Analysis and Machine Learning.
Mediators of inflammation
Oct 25, 2023
Ulcerative colitis (UC) is an inflammatory bowel disease of unknown cause that typically affects the colon and rectum. Innate intestinal immunity, including macrophages, plays a significant role in the pathological development of UC. Using the CIBERS...
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