AIMC Topic: Male

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Identification of a panel of volatile organic compounds in urine for early detection of for bladder cancer.

Scientific reports
The absence of specific markers makes early detection of bladder cancer (BC) challenging. Recent studies have reported the reliable diagnostic significance of volatile organic compounds (VOCs) in several cancers. This study aimed to investigate wheth...

Intestinal permeability of N-acetylcysteine is driven by gut microbiota-dependent cysteine palmitoylation.

Nature communications
Trillions of intestinal microbiota are essential to the permeability of orally administered drugs. However, identifying microbial-drug interactions remains challenging due to the highly variable composition of intestinal flora among individuals. Usin...

Feasibility study of a general model for synthetic CT generation in MRI-guided extracranial radiotherapy.

Biomedical physics & engineering express
This study aims to investigate the feasibility of a single general model to synthesize CT images across body sites, thorax, abdomen, and pelvis, to support treatment planning for MRI-only radiotherapy. A total of 157 patients who received MRI-guided ...

Development and validation of a nomogram for differentiating immune checkpoint inhibitor-related pneumonitis from pneumonia in patients undergoing immunochemotherapy: a multicenter, real-world, retrospective study.

Frontiers in immunology
BACKGROUND: Immune Checkpoint Inhibitor-related Pneumonitis (CIP) exhibits high morbidity and mortality rates in the real world, often coexisting with pneumonia, particularly after immunochemotherapy. We aimed to develop and validate a non-invasive n...

[Cluster predictors of trajectories of leisure-time physical activity intensity in men and women from ELSA-Brasil].

Cadernos de saude publica
The maintenance of physical activity over time is a challenge for public health. Predictors of different physical activity intensities have not been sufficiently analyzed. This study aimed to identify clusters of trajectories of physical activity int...

A data-driven scoring framework for personalized employee health check-ups: Integrating historical laboratory trends and evidence-based prevalence.

International journal of medical informatics
INTRODUCTION: Rising healthcare costs and growing demand for personalized preventive care have highlighted the need for data-driven approaches to optimize health check-ups, particularly in corporate settings. This study presents a scoring-based platf...

3D+t Multifocal Imaging Dataset of Human Sperm.

Scientific data
Understanding human fertility requires dynamic and three-dimensional (3D) analysis of sperm movement, which extends beyond the capabilities of traditional datasets focused primarily on two-dimensional sperm motility or static morphological characteri...

Global burden of vertebral fractures from 1990 to 2021 and projections for the next three decades.

Journal of orthopaedic surgery and research
BACKGROUND: Vertebral fractures are linked to significant disability and mortality risks. Yet, existing studies on their global burden are outdated and lack predictive foresight.

Brain metabolic imaging-based model identifies cognitive stability in prodromal Alzheimer's disease.

Scientific reports
The recent approval of anti-amyloid pharmaceuticals for the treatment of Alzheimer's disease (AD) has created a pressing need for the ability to accurately identify optimal candidates for anti-amyloid therapy, specifically those with evidence for inc...

Construction and validation of a pain facial expressions dataset for critically ill children.

Scientific reports
Automatic pain assessment for non-communicative children is in high demand. However, the availability of related training datasets remains limited. This study focuses on creating a large-scale dataset of pain facial expressions specifically for Chine...