AIMC Topic: MAP Kinase Signaling System
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Deciphering the history of ERK activity from fixed-cell immunofluorescence measurements.
Nature communications
May 21, 2025
The RAS/ERK pathway plays a central role in diagnosis and therapy for many cancers. ERK activity is highly dynamic within individual cells and drives cell proliferation, metabolism, and other processes through effector proteins including c-Myc, c-Fos...
Mitochondrial dysfunction and cell death induced by Toona sinensis leaf extracts through MEK/ERK signaling in glioblastoma cells.
PloS one
May 9, 2025
Toona sinensis, a kind of phytochemicals in traditional Chinese medicine widely used in South-East Asia, has been recognized for its anticancer properties, particularly against various types of cancer. We aimed to evaluate the effectiveness of T. sin...
ShenJiaoLingCao decoction ameliorates cyclophosphamide-induced splenic injury and immunosuppression via the inhibition of MEK/ERK signaling pathway activity and modulation of amino acid metabolism.
Journal of ethnopharmacology
Apr 16, 2025
ETHNOPHARMACOLOGICAL RELEVANCE: ShenJiaoLingCao Decoction (SJLCD) is derived from the classic Chinese medicine prescription, which consists of ten kinds of herbs. In China, SJLCD has been used as an immunomodulator in clinical practice for more than ...
Exploring the spatial effects influencing the EGFR/ERK pathway dynamics with machine learning surrogate models.
Bio Systems
Nov 7, 2024
The fate of cells is regulated by biochemical reactions taking place inside of them, known as intracellular pathways. Cells display a variety of characteristics related to their shape, structure and contained fluid, which influences the diffusion of ...
Screening of key biomarkers of tendinopathy based on bioinformatics and machine learning algorithms.
PloS one
Oct 29, 2021
Tendinopathy is a complex multifaceted tendinopathy often associated with overuse and with its high prevalence resulting in significant health care costs. At present, the pathogenesis and effective treatment of tendinopathy are still not sufficiently...
Machine-Learning and Chemicogenomics Approach Defines and Predicts Cross-Talk of Hippo and MAPK Pathways.
Cancer discovery
Nov 18, 2020
Hippo pathway dysregulation occurs in multiple cancers through genetic and nongenetic alterations, resulting in translocation of YAP to the nucleus and activation of the TEAD family of transcription factors. Unlike other oncogenic pathways such as RA...
Quantitative Structure-Mutation-Activity Relationship Tests (QSMART) model for protein kinase inhibitor response prediction.
BMC bioinformatics
Nov 12, 2020
BACKGROUND: Protein kinases are a large family of druggable proteins that are genomically and proteomically altered in many human cancers. Kinase-targeted drugs are emerging as promising avenues for personalized medicine because of the differential r...
Propofol affects the growth and metastasis of pancreatic cancer via ADAM8.
Pharmacological reports : PR
Dec 20, 2019
BACKGROUND: Anesthesia is a major component of surgery and recently considered an important regulator of cell phenotypes. Here we aimed to investigate propofol, an anesthesia drug, in suppressing pancreatic cancer (PDAC), focusing on A disintegrin an...
ADAM Proteins
Mice, SCID
Propofol
Xenograft Model Antitumor Assays
Cell Movement
Cell Line, Tumor
Matrix Metalloproteinase 9
Neoplasm Metastasis
Apoptosis
Membrane Proteins
MAP Kinase Signaling System
Neoplasm Invasiveness
Humans
Matrix Metalloproteinase 2
Cell Proliferation
Pancreatic Neoplasms
Animals
Antineoplastic Agents
Screening and Bioinformatics Analysis of IgA Nephropathy Gene Based on GEO Databases.
BioMed research international
Jul 16, 2019
PURPOSE: To identify novel biomarkers of IgA nephropathy (IgAN) through bioinformatics analysis and elucidate the possible molecular mechanism.
Protective effect of polysaccharide from Sophora japonica L. flower buds against UVB radiation in a human keratinocyte cell line (HaCaT cells).
Journal of photochemistry and photobiology. B, Biology
Dec 5, 2018
Natured botanical extract has attracted considerable attention recently in the field of skin anti-ultraviolet (UV) radiation. As a medicinal herb, Sophora japonica flower buds contained several components such as flavonoids, isoflavonoids, triterpene...
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