AIMC Topic: Mesenchymal Stem Cells
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Effect of Short-Term Stimulation with Interleukin-1β and Differentiation Medium on Human Mesenchymal Stromal Cell Paracrine Activity in Coculture with Osteoblasts.
BioMed research international
Dec 22, 2015
INTRODUCTION: Human mesenchymal stromal cells (hMSCs) exhibit the potential to accelerate bone healing by enhanced osteogenic differentiation. Interleukin-1β is highly expressed during fracture healing and has been demonstrated to exert a significant...
Mesenchymal stem cell transplantation ameliorates inflammation in spinal cord injury by inhibiting lactylation-related genes.
Cytokine
Jul 1, 2025
BACKGROUND: The immune microenvironment significantly influences neural regeneration in spinal cord injury (SCI). Lactate activates central nervous system (CNS) glial cells, prompting the secretion of proinflammatory cytokines and triggering an infla...
Deciphering the Regulatory Networks of the Migrasome-Associated Cell Subpopulation in Heterotopic Ossification via Multi-Omics Analysis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Jun 30, 2025
Heterotopic ossification (HO) is a pathological process where bone forms in extraskeletal tissues, often occurring as a complication of tissue repair following injury. This condition can lead to movement limitations, pain, and functional impairment. ...
Developments in Stem Cell Therapy by Utilizing Artificial Intelligence.
Current pharmaceutical design
Jan 1, 2023
Undifferentiated cells, known as stem cells, have the capacity to self-renew and specialise in a variety of distinct mature and functional cell types while still retaining their original identity. For their significance in regenerative medicine, stem...
Quantitative scoring of epithelial and mesenchymal qualities of cancer cells using machine learning and quantitative phase imaging.
Journal of biomedical optics
Feb 1, 2020
SIGNIFICANCE: We introduce an application of machine learning trained on optical phase features of epithelial and mesenchymal cells to grade cancer cells' morphologies, relevant to evaluation of cancer phenotype in screening assays and clinical biops...
Human adipose-derived mesenchymal stem cell-based medical microrobot system for knee cartilage regeneration in vivo.
Science robotics
Jan 22, 2020
Targeted cell delivery by a magnetically actuated microrobot with a porous structure is a promising technique to enhance the low targeting efficiency of mesenchymal stem cell (MSC) in tissue regeneration. However, the relevant research performed to d...
Cell Proliferation
Robotics
Cell Differentiation
Equipment Design
Humans
Cells, Cultured
Animals
Regeneration
Microscopy, Electron, Scanning
Tissue Scaffolds
Electromagnetic Phenomena
Robotic Surgical Procedures
Knee Joint
Rabbits
Mesenchymal Stem Cells
Mesenchymal Stem Cell Transplantation
Polylactic Acid-Polyglycolic Acid Copolymer
Cell Adhesion
Cartilage, Articular
Cell- and Tissue-Based Therapy
Practical and Safe Method of Long-Term Cryopreservation for Clinical Application of Human Adipose-Derived Mesenchymal Stem Cells Without a Programmable Freezer Or Serum.
Cryo letters
Jan 1, 2020
BACKGROUND: Adipose-derived mesenchymal stem cells (ADSCs) have emerged as a promising modality for cellular therapy. However, techniques of ADSC cryopreservation, which can facilitate their clinical application, haven't been established yet.
[rhPDGF-BB promotes migration of bone marrow stromal stem cells in diabetic rats].
Shanghai kou qiang yi xue = Shanghai journal of stomatology
Dec 1, 2018
PURPOSE: To evaluate the effect of different concentrations of rhPDGF-BB on bone marrow stromal stem cells(BMSCs) migration in diabetic rat, and related mechanisms of SDF-1 and its G-protein conjugated receptor regulation, provide a theoretical basis...
[Acupoint injection of BMSCs combined with Chinese herbs for capillary density in ischemic hind limb of diabetes mellitus rats].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion
Sep 12, 2018
OBJECTIVE: To observe the effect of acupoint injection of bone mesenchymal stem cells (BMSCs) combined with Chinese herbs of benefiting for activating blood circulation for capillary density and arterioles density in skeletal muscle in ischemic hind...
[Construction of Recombinant Adenovirus Vector with Human/Mouse Interferon Gene and Its Transfection into Human Umbilical Cord Mesenchymal Stem Cells].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
Nov 1, 2015
OBJECTIVE: Construction and identification of recombinant adenovirus vector with human/mouse interferon (IFN-gamma) and effectively transfection into human umbilical cord mesenchymal stem cells (HUMSCs).
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