AIMC Topic: Mice
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AxonDeepSeg: automatic axon and myelin segmentation from microscopy data using convolutional neural networks.
Scientific reports
Feb 28, 2018
Segmentation of axon and myelin from microscopy images of the nervous system provides useful quantitative information about the tissue microstructure, such as axon density and myelin thickness. This could be used for instance to document cell morphom...
A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters.
Nature chemical biology
Feb 26, 2018
We developed a new way to engineer complex proteins toward multidimensional specifications using a simple, yet scalable, directed evolution strategy. By robotically picking mammalian cells that were identified, under a microscope, as expressing prote...
Gene function prediction based on Gene Ontology Hierarchy Preserving Hashing.
Genomics
Feb 23, 2018
Gene Ontology (GO) uses structured vocabularies (or terms) to describe the molecular functions, biological roles, and cellular locations of gene products in a hierarchical ontology. GO annotations associate genes with GO terms and indicate the given ...
Towards enhanced metabolomic data analysis of mass spectrometry image: Multivariate Curve Resolution and Machine Learning.
Analytica chimica acta
Feb 20, 2018
Large amounts of data are generally produced from mass spectrometry imaging (MSI) experiments in obtaining the molecular and spatial information of biological samples. Traditionally, MS images are constructed using manually selected ions, and it is v...
Support vector machines for explaining physiological stress response in Wood mice (Apodemus sylvaticus).
Scientific reports
Feb 7, 2018
Physiological stress response is a crucial adaptive mechanism for prey species survival. This paper aims to identify the main environmental and/or individual factors better explaining the stress response in Wood mice, Apodemus sylvaticus. We analyzed...
Critical texture pattern feature assessment for characterizing colonies of induced pluripotent stem cells through machine learning techniques.
Computers in biology and medicine
Jan 31, 2018
The objectives of this study are to assess various automated texture features obtained from the segmented colony regions of induced pluripotent stem cells (iPSCs) and confirm their potential for characterizing the colonies using different machine lea...
Multi-neuron intracellular recording in vivo via interacting autopatching robots.
eLife
Jan 3, 2018
The activities of groups of neurons in a circuit or brain region are important for neuronal computations that contribute to behaviors and disease states. Traditional extracellular recordings have been powerful and scalable, but much less is known abo...
Detection of nanodiamonds in biological samples by EPR spectrometry.
Doklady. Biochemistry and biophysics
Jan 3, 2018
In model experiments in vitro, the applicability of the EPR spectrometry method for the detection of modified nanodiamonds (MNDs) in blood and homogenates of mouse organs has been established. A characteristic signal (g = 2.003, ΔH ≈ 10 G) is observe...
Carboxybetaine-modified succinylated chitosan-based beads encourage pancreatic β-cells (Min-6) to form islet-like spheroids under in vitro conditions.
Journal of materials science. Materials in medicine
Dec 30, 2017
In vitro, pancreatic β-cells tend to reduce their ability to aggregate into islets and lose insulin-producing ability, likely due to insufficient cell-cell and cell-matrix interactions that are essential for β-cell retention, viability and functional...
Molecular Dynamics Simulation
Insulin Secretion
Lasers
Animals
Microscopy, Electron, Scanning
Insulin
Trans-Activators
Cell Survival
Surface Properties
Mice
Insulin-Secreting Cells
Homeodomain Proteins
Spectroscopy, Fourier Transform Infrared
Chitosan
Cell Culture Techniques
Scattering, Radiation
Carbon
Microscopy, Fluorescence
Betaine
Cadherins
Spheroids, Cellular
Essential oil of Citrus lumia Risso: Phytochemical profile, antioxidant properties and activity on the central nervous system.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Dec 28, 2017
The use of essential oils (EOs) is known since long time in traditional medicine and aromatherapy for the management of various oxidative stress-related disorders and has been further increased recently for their neuroprotective and anti-aging potent...
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