FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Oct 31, 2025
Dilated cardiomyopathy (DCM) is a progressive myocardial disorder lacking reliable molecular biomarkers for early diagnosis. Given the emerging role of protein lactylation in cardiovascular disease, we investigated lactylation-related genes (LRGs) in...
OBJECTIVE: Skeletal muscle is crucial for glucose metabolism, but diabetes impairs this function, leading to muscle atrophy. Although the mutation of BOLA Family Member 3 (BOLA3) resulted in disease Multiple Mitochondrial Dysfunctions Syndrome, the r...
The hippocampus, including the cornu ammonis (CA) and dentate gyrus (DG) subregions, is a brain area highly susceptible to seizure-like activity (SLA). Most studies conducted in vivo have been performed in a single hippocampal subregion. In our study...
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Oct 15, 2025
Diabetic retinopathy (DR) and retinopathy of prematurity (ROP) continue to be significant causes of vision impairment despite the well-established role of vascular endothelial growth factor (VEGF) in pathological angiogenesis. We still need to deeply...
UNLABELLED: Alterations to N6-methyladenosine (m6A) modifications can promote malignant progression by modulating gene expression through regulation of transcript metabolism. Quantifying the causal impact of m6A dysregulation at the population level ...
UNLABELLED: Identifying functionally important cell states and structure within heterogeneous tumors remains a significant biological and computational challenge. Current clustering- or trajectory-based models are ill-equipped to address the notion t...
BACKGROUND: Relapse and drug resistance are major contributor to chemotherapy failure in diffuse large B-cell lymphoma (DLBCL). Programmed cell death (PCD), a key mechanism in tumor progression and resistance, has emerged as a promising biomarker for...
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Sep 15, 2025
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent hepatic metabolic disorder with a rising global incidence. Epigenetic modifications-such as methylation, acetylation, phosphorylation, and ubiquitination-play critical ro...
Mitochondrial function plays a crucial role in understanding the pathogenesis of acute myocardial infarction.This study investigates mitochondrial function-related genes (MFRGs) in acute myocardial infarction (AMI) through bioinformatics and rigorous...
AIMS: This study investigates the role of macrophage histone lactylation-a protein modification-in atherosclerosis progression, particularly in peripheral artery disease (PAD), and evaluates the therapeutic potential of the herbal formula Ruan Jian Q...
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