AIMC Topic: Mice

Clear Filters Showing 181 to 190 of 1493 articles

Opioid growth factor receptor overexpression exerts anti-hepatocellular carcinoma effects by activating P16 and P21 to inhibit proliferation and migration of HepG2 cells.

Folia histochemica et cytobiologica Jan 13, 2025
INTRODUCTION: Hepatocellular carcinoma (HCC) is the sixth most common type of cancer and the second leading cause of cancer death worldwide [19]. Opioid growth factor (OGF) has been shown to exhibit antitumour potential, binding to OGF receptor (OGFr...
Mice, Inbred BALB C Cyclin-Dependent Kinase Inhibitor p21 Receptors, Opioid Cyclin-Dependent Kinase Inhibitor p16 Apoptosis Cell Proliferation Hep G2 Cells Cell Movement Mice, Nude Liver Neoplasms Carcinoma, Hepatocellular Mice Humans Animals Male
View on PubMed DOI

Machine Learning-Assisted High-Throughput Screening of Nanozymes for Ulcerative Colitis.

Advanced materials (Deerfield Beach, Fla.) Jan 12, 2025
Ulcerative colitis (UC) is a chronic gastrointestinal inflammatory disorder with rising prevalence. Due to the recurrent and difficult-to-treat nature of UC symptoms, current pharmacological treatments fail to meet patients' expectations. This study ...
High-Throughput Screening Assays Machine Learning Animals Mice Antioxidants Gastrointestinal Microbiome Apoptosis Reactive Oxygen Species Humans Colitis, Ulcerative
View on PubMed DOI

Diagnostic Accuracy of Ambient Mass Spectrometry with Blood Plasma in a Murine Glioma Model Using Machine Learning.

World neurosurgery Jan 9, 2025
OBJECTIVE: Malignant glioma progresses rapidly and shows poor prognosis, but clinically applicable blood plasma-based biochemical tumor markers remain lacking. This study aimed to develop a diagnostic system using probe electrospray ionization mass s...
Machine Learning Biomarkers, Tumor Glioma Brain Neoplasms Animals Disease Models, Animal Male Mice, Inbred C57BL Cell Line, Tumor Spectrometry, Mass, Electrospray Ionization Mice
View on PubMed DOI

ULM-MbCNRT: In Vivo Ultrafast Ultrasound Localization Microscopy by Combining Multibranch CNN and Recursive Transformer.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control Jan 8, 2025
Ultrasound localization microscopy (ULM) overcomes the acoustic diffraction limit by localizing tiny microbubbles (MBs), thus enabling the microvascular to be rendered at subwavelength resolution. Nevertheless, to obtain such superior spatial resolut...
Neural Networks, Computer Algorithms Animals Microbubbles Deep Learning Phantoms, Imaging Microscopy, Acoustic Ultrasonography Image Processing, Computer-Assisted Mice
View on PubMed DOI

Comprehensive bioinformatics analysis identifies metabolic and immune-related diagnostic biomarkers shared between diabetes and COPD using multi-omics and machine learning.

Frontiers in endocrinology Jan 8, 2025
BACKGROUND: Diabetes and chronic obstructive pulmonary disease (COPD) are prominent global health challenges, each imposing significant burdens on affected individuals, healthcare systems, and society. However, the specific molecular mechanisms suppo...
Pulmonary Disease, Chronic Obstructive Mice Humans Animals Computational Biology Gene Expression Profiling Machine Learning Multiomics Gene Regulatory Networks Biomarkers Diabetes Mellitus
View on PubMed DOI

From Genes to Metabolites: HSP90B1's Role in Alzheimer's Disease and Potential for Therapeutic Intervention.

Neuromolecular medicine Jan 6, 2025
Alzheimer's disease (AD) is a prototypical neurodegenerative disorder, predominantly affecting individuals in the presenile and elderly populations, with an etiology that remains elusive. This investigation aimed to elucidate the alterations in anoik...
Hippocampus Gene Expression Regulation Mice, Transgenic HSP90 Heat-Shock Proteins Male Mice Disease Models, Animal Mice, Inbred C57BL Cell Survival MicroRNAs Amyloid beta-Peptides Alzheimer Disease Humans Biomarkers Machine Learning Female Aged Animals
View on PubMed DOI

Integrating bioinformatics and machine learning to identify AhR-related gene signatures for prognosis and tumor microenvironment modulation in melanoma.

Frontiers in immunology Jan 6, 2025
BACKGROUND: The Aryl Hydrocarbon Receptor (AhR) pathway significantly influences immune cell regulation, impacting the effectiveness of immunotherapy and patient outcomes in melanoma. However, the specific downstream targets and mechanisms by which A...
Gene Expression Profiling Transcriptome Mice Computational Biology Skin Neoplasms Tumor Microenvironment Biomarkers, Tumor Animals Basic Helix-Loop-Helix Transcription Factors Gene Expression Regulation, Neoplastic Humans Lymphocytes, Tumor-Infiltrating Machine Learning Receptors, Aryl Hydrocarbon Prognosis Databases, Genetic Melanoma
View on PubMed DOI

Deciphering the cellular and molecular landscape of pulmonary fibrosis through single-cell sequencing and machine learning.

Journal of translational medicine Jan 2, 2025
Pulmonary fibrosis is characterized by progressive lung scarring, leading to a decline in lung function and an increase in morbidity and mortality. This study leverages single-cell sequencing and machine learning to unravel the complex cellular and m...
Humans Machine Learning Animals Male Mice, Inbred C57BL Fibroblasts Pulmonary Fibrosis Gene Expression Regulation Lung Single-Cell Analysis Mice Bleomycin
View on PubMed DOI

Deep learning-based aberration compensation improves contrast and resolution in fluorescence microscopy.

Nature communications Jan 2, 2025
Optical aberrations hinder fluorescence microscopy of thick samples, reducing image signal, contrast, and resolution. Here we introduce a deep learning-based strategy for aberration compensation, improving image quality without slowing image acquisit...
Mice Neural Networks, Computer Animals Microscopy, Confocal Deep Learning Microscopy, Fluorescence Image Processing, Computer-Assisted Caenorhabditis elegans
View on PubMed DOI

ChromatinHD connects single-cell DNA accessibility and conformation to gene expression through scale-adaptive machine learning.

Nature communications Jan 2, 2025
Gene regulation is inherently multiscale, but scale-adaptive machine learning methods that fully exploit this property in single-nucleus accessibility data are still lacking. Here, we develop ChromatinHD, a pair of scale-adaptive models that uses the...
Chromatin Immunoprecipitation Sequencing Gene Expression Regulation Nucleic Acid Conformation Regulatory Sequences, Nucleic Acid Chromatin Humans Machine Learning Animals Single-Cell Analysis Mice Computational Biology Transcription Factors DNA
View on PubMed DOI
Popular Topics
Recent Journals