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Neoplasm Invasiveness

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Spatially-resolved analyses of muscle invasive bladder cancer microenvironment unveil a distinct fibroblast cluster associated with prognosis.

Frontiers in immunology
BACKGROUND: Muscle-invasive bladder cancer (MIBC) is a prevalent cancer characterized by molecular and clinical heterogeneity. Assessing the spatial heterogeneity of the MIBC microenvironment is crucial to understand its clinical significance.

CXCL12 impact on glioblastoma cells behaviors under dynamic culture conditions: Insights for developing new therapeutic approaches.

PloS one
Glioblastoma multiforme (GBM) is the most prevalent malignant brain tumor, with an average survival time of 14 to 20 months. Its capacity to invade brain parenchyma leads to the failure of conventional treatments and subsequent tumor recurrence. Rece...

MRI-based radiomic and machine learning for prediction of lymphovascular invasion status in breast cancer.

BMC medical imaging
OBJECTIVE: Lymphovascular invasion (LVI) is critical for the effective treatment and prognosis of breast cancer (BC). This study aimed to investigate the value of eight machine learning models based on MRI radiomic features for the preoperative predi...

Machine Learning Prediction of Early Recurrence in Gastric Cancer: A Nationwide Real-World Study.

Annals of surgical oncology
BACKGROUND: Patients with gastric cancer (GC) who experience early recurrence (ER) within 2 years postoperatively have poor prognoses. This study aimed to analyze and predict ER after curative surgery for patients with GC using machine learning (ML) ...

Radiomics and deep learning models for glioblastoma treatment outcome prediction based on tumor invasion modeling.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
PURPOSE: We investigate the feasibility of using a biophysically guided approach for delineating the Clinical Target Volume (CTV) in Glioblastoma Multiforme (GBM) by evaluating its impact on the treatment outcomes, specifically Overall Survival (OS) ...

Personalized predictions of Glioblastoma infiltration: Mathematical models, Physics-Informed Neural Networks and multimodal scans.

Medical image analysis
Predicting the infiltration of Glioblastoma (GBM) from medical MRI scans is crucial for understanding tumor growth dynamics and designing personalized radiotherapy treatment plans. Mathematical models of GBM growth can complement the data in the pred...

Deep learning detected histological differences between invasive and non-invasive areas of early esophageal cancer.

Cancer science
The depth of invasion plays a critical role in predicting the prognosis of early esophageal cancer, but the reasons behind invasion and the changes occurring in invasive areas are still not well understood. This study aimed to explore the morphologic...

Deep learning-based prediction of tumor aggressiveness in RCC using multiparametric MRI: a pilot study.

International urology and nephrology
OBJECTIVE: To investigate the value of multiparametric magnetic resonance imaging (MRI) as a non-invasive method to predict the aggressiveness of renal cell carcinoma (RCC) by developing a convolutional neural network (CNN) model and fusing it with c...

The Value of Machine Learning-based Radiomics Model Characterized by PET Imaging with Ga-FAPI in Assessing Microvascular Invasion of Hepatocellular Carcinoma.

Academic radiology
RATIONALE AND OBJECTIVES: This study aimed to develop a radiomics model characterized by Ga-fibroblast activation protein inhibitors (FAPI) positron emission tomography (PET) imaging to predict microvascular invasion (MVI) of hepatocellular carcinoma...