AIMC Topic: Nuclear Proteins

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An Integrated Approach Fusing CEEMD Energy Entropy and Sparrow Search Algorithm-Based PNN for Fault Diagnosis of Rolling Bearings.

Computational intelligence and neuroscience
This paper solves the problem of difficulty in achieving satisfactory results with traditional methods of bearing fault diagnosis, which can effectively extract the fault information and improve the fault diagnosis accuracy. This paper proposes a nov...

MAFF-Net: Multi-Attention Guided Feature Fusion Network for Change Detection in Remote Sensing Images.

Sensors (Basel, Switzerland)
One of the most important tasks in remote sensing image analysis is remote sensing image Change Detection (CD), and CD is the key to helping people obtain more accurate information about changes on the Earth's surface. A Multi-Attention Guided Featur...

Machine learning prediction of cyanobacterial toxin (microcystin) toxicodynamics in humans.

ALTEX
Microcystins (MC) represent a family of cyclic peptides with approx. 250 congeners presumed harmful to human health due to their ability to inhibit ser/thr-proteinphosphatases (PPP), albeit all hazard and risk assessments (RA) are based on data of on...

A machine learning approach to integrate big data for precision medicine in acute myeloid leukemia.

Nature communications
Cancers that appear pathologically similar often respond differently to the same drug regimens. Methods to better match patients to drugs are in high demand. We demonstrate a promising approach to identify robust molecular markers for targeted treatm...

Comparison of Selected Parameters of Redox Homeostasis in Patients with Ataxia-Telangiectasia and Nijmegen Breakage Syndrome.

Oxidative medicine and cellular longevity
This study compared the antioxidant status and major lipophilic antioxidants in patients with ataxia-telangiectasia (AT) and Nijmegen breakage syndrome (NBS). Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), a...

Machine-Learning-Assisted Approach for Discovering Novel Inhibitors Targeting Bromodomain-Containing Protein 4.

Journal of chemical information and modeling
Bromodomain-containing protein 4 (BRD4) is implicated in the pathogenesis of a number of different cancers, inflammatory diseases and heart failure. Much effort has been dedicated toward discovering novel scaffold BRD4 inhibitors (BRD4is) with differ...

Correcting the impact of docking pose generation error on binding affinity prediction.

BMC bioinformatics
BACKGROUND: Pose generation error is usually quantified as the difference between the geometry of the pose generated by the docking software and that of the same molecule co-crystallised with the considered protein. Surprisingly, the impact of this e...