AIMC Topic: Pseudomonas aeruginosa

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DEEPred: Automated Protein Function Prediction with Multi-task Feed-forward Deep Neural Networks.

Scientific reports May 14, 2019
Automated protein function prediction is critical for the annotation of uncharacterized protein sequences, where accurate prediction methods are still required. Recently, deep learning based methods have outperformed conventional algorithms in comput...
Humans Neural Networks, Computer Models, Biological Software Pseudomonas aeruginosa Deep Learning Data Mining Biofilms Gene Ontology Proteins Pseudomonas Infections Bacterial Proteins
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Albumin binding, anticancer and antibacterial properties of synthesized zero valent iron nanoparticles.

International journal of nanomedicine Dec 28, 2018
BACKGROUND: Nanoparticles (NPs) have been emerging as potential players in modern medicine with clinical applications ranging from therapeutic purposes to antimicrobial agents. However, before applications in medical agents, some in vitro studies sho...
Iron Pseudomonas aeruginosa Humans Bacteria Tumor Cells, Cultured Protein Conformation Anti-Bacterial Agents Cell Proliferation Neuroblastoma Molecular Docking Simulation Escherichia coli Serum Albumin, Human Antineoplastic Agents Staphylococcus aureus Metal Nanoparticles
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Amino acid conjugated antimicrobial drugs: Synthesis, lipophilicity- activity relationship, antibacterial and urease inhibition activity.

European journal of medicinal chemistry Dec 29, 2017
Present work describes the in vitro antibacterial evaluation of some new amino acid conjugated antimicrobial drugs. Structural modification was attempted on the three existing antimicrobial pharmaceuticals namely trimethoprim, metronidazole, isoniazi...
Trimethoprim Hydrophobic and Hydrophilic Interactions Enzyme Inhibitors Bacillus Isoniazid Anti-Bacterial Agents Amino Acids Microbial Sensitivity Tests Urease Escherichia coli Metronidazole Staphylococcus aureus Pseudomonas aeruginosa Dose-Response Relationship, Drug Salmonella typhi Structure-Activity Relationship Molecular Structure
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Effect of nano-silver, nano-copper, deconex and benzalkonium chloride on biofilm formation and expression of transcription regulatory quorum sensing gene (rh1R) in drug-resistance Pseudomonas aeruginosa burn isolates.

Burns : journal of the International Society for Burn Injuries Dec 28, 2017
BACKGROUND: Biofilm forming drug-resistant Pseudomonas aeruginosa are responsible for major death in burn center of different hospitals across the globe.
Metal Nanoparticles Gene Expression Bacterial Proteins Copper Silver Drug Resistance, Bacterial Anti-Infective Agents Biofilms Microbial Sensitivity Tests RNA, Messenger Anti-Infective Agents, Local Burns Pseudomonas aeruginosa Disinfectants Benzalkonium Compounds Polymerase Chain Reaction Humans
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R-100 improves pulmonary function and systemic fluid balance in sheep with combined smoke-inhalation injury and Pseudomonas aeruginosa sepsis.

Journal of translational medicine Dec 28, 2017
BACKGROUND: Septic shock is a major cause of death in intensive care units around the world . The aim of the study was to investigate whether the novel drug R-100 (a superoxide degradation catalyst and nitric oxide donor) improves pulmonary function ...
Female Animals Lung Hemodynamics Respiratory Function Tests Superoxides Smoke Inhalation Injury Sepsis Nitric Oxide Donors Blood Proteins Pulmonary Gas Exchange Body Fluids Pseudomonas aeruginosa Sheep
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Design and synthesis of cell selective α/β-diastereomeric peptidomimetic with potent in vivo antibacterial activity against methicillin resistant S. Aureus.

Bioorganic chemistry Dec 26, 2017
Design of therapeutically viable antimicrobial peptides with cell selectivity against microorganisms is an important step towards the development of new antimicrobial agents. Here, we report four de novo designed, short amphipathic sequences based on...
Keratinocytes Enterococcus faecalis Phosphatidylcholines Erythrocytes Acinetobacter baumannii Escherichia coli Hemolysis Methicillin-Resistant Staphylococcus aureus Lipid Bilayers Mice, Inbred BALB C Peptidomimetics Amino Acid Sequence Phosphatidylglycerols Pseudomonas aeruginosa Humans Stereoisomerism Anti-Bacterial Agents Female Animals Microbial Sensitivity Tests
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Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients.

International journal of antimicrobial agents Dec 22, 2017
Dosing recommendations for continuous infusion of piperacillin, a broad-spectrum beta-lactam antibiotic, are mainly guided by outputs from population pharmacokinetic models constructed with intermittent infusion data. However, the probability of targ...
Penicillanic Acid Piperacillin Pseudomonas Infections Humans Infusions, Intravenous Anti-Bacterial Agents Creatinine Critical Illness Pseudomonas aeruginosa Female Tazobactam Middle Aged Male Metabolic Clearance Rate Sepsis Microbial Sensitivity Tests Kidney Function Tests Drug Combinations
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Determination of total plasma oxysterols by enzymatic hydrolysis, solid phase extraction and liquid chromatography coupled to mass-spectrometry.

Journal of pharmaceutical and biomedical analysis Dec 21, 2017
The potential use of cholesterol esterases was tested to avoid alkaline hydrolysis for cleavage of plasma esterified oxysterols. The enzymatic hydrolysis was optimized by testing two sources of enzyme-Pseudomonas and bovine pancreas, presence of surf...
Hydrolysis Animals, Genetically Modified Calibration Reference Standards Cytochrome P450 Family 7 Oxysterols Rats, Inbred F344 Steroid Hydroxylases Sterol Esterase Chromatography, Liquid Humans Bacterial Proteins Tandem Mass Spectrometry Reproducibility of Results Pseudomonas aeruginosa Animals Solid Phase Extraction Male
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Antibacterial mechanisms of a novel type picosecond laser-generated silver-titanium nanoparticles and their toxicity to human cells.

International journal of nanomedicine Dec 20, 2017
In this study, we explored the antibacterial mechanisms for a novel type of Ag-TiO compound nanoparticles (NPs) produced from an Ag-TiO alloy using a picosecond laser and evaluated the toxicity of the Ag-TiO NPs to a range of human cell types. Transm...
Cell Line Reactive Oxygen Species Metal Nanoparticles Titanium Silver Pseudomonas aeruginosa Lasers HEK293 Cells Gram-Positive Bacteria Microscopy, Electron, Transmission Humans Anti-Bacterial Agents Escherichia coli Methicillin-Resistant Staphylococcus aureus
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Innovative material containing the natural product curcumin, with enhanced antimicrobial properties for active packaging.

Materials science & engineering. C, Materials for biological applications Nov 28, 2017
Curcumin (Curc) reacts with zinc di‑iodine (ZnI) in 2:1molar ratio in the presence of an excess of a base triethylamine ((CHCH)N) in methanol (CHOH) solution towards the amorphous solid material of formula [ZnI(Curc)] (1). The complex was characteriz...
X-Ray Diffraction Coordination Complexes Magnetic Resonance Spectroscopy Anti-Infective Agents Biological Products Microbial Sensitivity Tests Curcumin Zinc Pseudomonas aeruginosa Spectroscopy, Fourier Transform Infrared Polystyrenes Drug Compounding
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