AIMC Topic: Spinal Cord
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Microglial pruning of glycinergic synapses disinhibits spinal PKCĪ³ interneurons to drive pain hypersensitivity in mice.
Science translational medicine
Jun 18, 2025
Microglial activation is linked to neuroinflammation in neuropathic pain. Recently, microglia-mediated synaptic pruning has received mounting attention. However, the exact role of spinal microglia in modulating neuropathic pain-associated neural circ...
Decreased spinal inhibition leads to undiversified locomotor patterns.
Biological cybernetics
Jun 4, 2025
During walking and running, animals display rich and coordinated motor patterns that are generated and controlled within the central nervous system. Previous computational and experimental results suggest that the balance between excitation and inhib...
Fast, accurate, and versatile data analysis platform for the quantification of molecular spatiotemporal signals.
Cell
Apr 8, 2025
Optical recording of intricate molecular dynamics is becoming an indispensable technique for biological studies, accelerated by the development of new or improved biosensors and microscopy technology. This creates major computational challenges to ex...
Augmenting rehabilitation robotics with spinal cord neuromodulation: A proof of concept.
Science robotics
Mar 12, 2025
Rehabilitation robotics aims to promote activity-dependent reorganization of the nervous system. However, people with paralysis cannot generate sufficient activity during robot-assisted rehabilitation and, consequently, do not benefit from these ther...
Towards contrast-agnostic soft segmentation of the spinal cord.
Medical image analysis
Jan 21, 2025
Spinal cord segmentation is clinically relevant and is notably used to compute spinal cord cross-sectional area (CSA) for the diagnosis and monitoring of cord compression or neurodegenerative diseases such as multiple sclerosis. While several semi an...
Machine learning identified novel players in lipid metabolism, endosomal trafficking, and iron metabolism of the ALS spinal cord.
Scientific reports
Jan 10, 2025
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting motor neurons. Although genes causing familial cases have been identified, those of sporadic ALS, which occupies the majority of patients, are still elusive. In this s...
VoxelMorph-Based Deep Learning Motion Correction for Ultrasound Localization Microscopy of Spinal Cord.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control
Jan 8, 2025
Accurate assessment of spinal cord vasculature is important for the urgent diagnosis of injury and subsequent treatment. Ultrasound localization microscopy (ULM) offers super-resolution imaging of microvasculature by localizing and tracking individua...
Deep-learning reconstruction enhances image quality of Adamkiewicz Artery in low-keV dual-energy CT.
Acta radiologica (Stockholm, Sweden : 1987)
Oct 22, 2024
BACKGROUND: Low-keV virtual monoenergetic images (VMIs) of dual-energy computed tomography (CT) enhances iodine contrast for detecting small arteries like the Adamkiewicz artery (AKA), but image noise can be problematic. Deep-learning image reconstru...
Dynamic changes in pyroptosis following spinal cord injury and the identification of crucial molecular signatures through machine learning and single-cell sequencing.
Journal of pharmaceutical and biomedical analysis
Aug 26, 2024
The pathological cascade of spinal cord injury (SCI) is highly intricate. The onset of neuroinflammation can exacerbate the extent of damage. Pyroptosis is a form of inflammation-linked programmed cell death (PCD), the inhibition of pyroptosis can pa...
A novel CNN-based image segmentation pipeline for individualized feline spinal cord stimulation modeling.
Journal of neural engineering
Jun 7, 2024
. Spinal cord stimulation (SCS) is a well-established treatment for managing certain chronic pain conditions. More recently, it has also garnered attention as a means of modulating neural activity to restore lost autonomic or sensory-motor function. ...
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