AIMC Topic: Sulfonamides

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Simultaneous determination of TPN729 and its five metabolites in human plasma and urine by liquid chromatography coupled to tandem mass spectrometry.

Journal of pharmaceutical and biomedical analysis Dec 30, 2017
A specific and sensitive method was firstly developed using high performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) to simultaneously quantify TPN729 and its metabolites (TPN729-D1, TPN729-D2, TPN729M15-3 and TPN729M...
Humans Biomarkers Chromatography, Liquid Sulfonamides Chromatography, High Pressure Liquid Tandem Mass Spectrometry Pyrimidinones
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The application of artificial neural networks and support vector regression for simultaneous spectrophotometric determination of commercial eye drop contents.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Dec 5, 2017
In the present study, artificial neural networks (ANNs) and support vector regression (SVR) as intelligent methods coupled with UV spectroscopy for simultaneous quantitative determination of Dorzolamide (DOR) and Timolol (TIM) in eye drop. Several sy...
Ophthalmic Solutions Sulfonamides Thiophenes Spectrophotometry, Ultraviolet Timolol Humans Neural Networks, Computer Support Vector Machine
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From word models to executable models of signaling networks using automated assembly.

Molecular systems biology Nov 24, 2017
Word models (natural language descriptions of molecular mechanisms) are a common currency in spoken and written communication in biomedicine but are of limited use in predicting the behavior of complex biological networks. We present an approach to b...
Humans Neural Networks, Computer Antineoplastic Agents Natural Language Processing Vemurafenib Cell Line, Tumor DNA Damage Enzyme Inhibitors Computer Simulation Gene Expression Regulation, Neoplastic Sulfonamides Drug Resistance, Neoplasm Language Models, Genetic Indoles Tumor Suppressor Protein p53 Melanoma Signal Transduction Proto-Oncogene Proteins p21(ras) Skin Neoplasms Proto-Oncogene Proteins B-raf
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Sulfonamide-based non-alkyne LpxC inhibitors as Gram-negative antibacterial agents.

Bioorganic & medicinal chemistry letters Dec 24, 2016
We attempted to optimize sulfonamide-based non-alkyne LpxC inhibitors by focusing on improvements in enzyme inhibitory and antibacterial activity. It was discovered that inhibitors possessing 2-aryl benzofuran as a hydrophobe exhibited good activity....
Sulfonamides Gram-Negative Bacteria Amidohydrolases Anti-Bacterial Agents Drug Resistance, Bacterial Microbial Sensitivity Tests Structure-Activity Relationship
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Ombitasvir, paritaprevir, and ritonavir plus ribavirin for chronic hepatitis C virus genotype 4 infection in Egyptian patients with or without compensated cirrhosis (AGATE-II): a multicentre, phase 3, partly randomised open-label trial.

The lancet. Gastroenterology & hepatology Jun 16, 2016
BACKGROUND: In Egypt, chronic hepatitis C virus (HCV) infection occurs in around 10% of the population (about 8 million individuals), and is a leading cause of liver cirrhosis, hepatocellular carcinoma, and mortality. Although HCV genotype 4 constitu...
Macrocyclic Compounds Ribavirin Sustained Virologic Response Adult Valine Proline Male Drug Administration Schedule Humans Cyclopropanes Ritonavir Middle Aged Anilides Genotype Adolescent Carbamates Egypt Liver Cirrhosis Drug Therapy, Combination Antiviral Agents Lactams, Macrocyclic Female Sulfonamides Hepatitis C, Chronic Hepacivirus Aged Administration, Oral Aged, 80 and over Young Adult Treatment Outcome Follow-Up Studies
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Ombitasvir, paritaprevir, and ritonavir plus ribavirin in adults with hepatitis C virus genotype 4 infection and cirrhosis (AGATE-I): a multicentre, phase 3, randomised open-label trial.

The lancet. Gastroenterology & hepatology Jun 16, 2016
BACKGROUND: Hepatitis C virus (HCV) genotype 4 infection is most commonly reported in sub-Saharan Africa and the Middle East; however, prevalence is increasing worldwide through immigration. HCV genotype 4 accounts for 20% of all infections, but clin...
Humans Female Aged Lactams, Macrocyclic Aged, 80 and over Macrocyclic Compounds Hepacivirus Young Adult Ribavirin Proline Adult Sustained Virologic Response Ritonavir Drug Therapy, Combination Genotype Hepatitis C, Chronic Male Treatment Outcome Valine Middle Aged Follow-Up Studies Drug Administration Schedule Adolescent Cyclopropanes Anilides Antiviral Agents Sulfonamides Carbamates
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A simple, accurate, time-saving and green method for the determination of 15 sulfonamides and metabolites in serum samples by ultra-high performance supercritical fluid chromatography.

Journal of chromatography. A Dec 31, 2015
An analytical method based on ultra-high performance supercritical fluid chromatography (UHPSFC) with photo-diode array detection (PDA) has been developed to quantify 15 sulfonamides and their N4-acetylation metabolites in serum. Under the optimized ...
Sulfonamides Chromatography, Supercritical Fluid Sulfanilamides Humans
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Urodynamic Efficacy and Safety of Mirabegron Add-on Treatment with Tamsulosin for Japanese Male Patients with Overactive Bladder.

Lower urinary tract symptoms Feb 17, 2015
OBJECTIVES: To investigate urodynamic efficacy and safety of mirabegron add-on treatment with tamsulosin for Japanese male patients with overactive bladder (OAB).
Thiazoles Urination Adrenergic beta-Agonists Urodynamics Urological Agents Middle Aged Treatment Outcome Sulfonamides Drug Therapy, Combination Acetanilides Tamsulosin Urinary Bladder, Overactive Humans Patient Safety Prospective Studies Aged Aged, 80 and over Male
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Machine learning-driven insights into retention mechanism in IAM chromatography of anticancer sulfonamides: Implications for biological efficacy.

Journal of chromatography. A Jun 21, 2025
Machine learning (ML) tools offer new opportunities in drug discovery, especially for enhancing our understanding of molecular interactions with biological systems. This study develops a comprehensive quantitative structure-retention relationship (QS...
Sulfonamides Chromatography, High Pressure Liquid Phospholipids Quantitative Structure-Activity Relationship Membranes, Artificial Humans Machine Learning Antineoplastic Agents Cell Line, Tumor
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Inhibition of choline kinase as an antiamoebic approach in Entamoeba histolytica infection.

Tropical biomedicine Dec 1, 2023
Entamoeba histolytica is the parasite responsible for amoebiasis, which can result in amoebic colitis or amoebic liver abscess. Metronidazole has been the conventional treatment for intestinal amoebiasis, but concerns regarding resistance have emerge...
Sulfonamides Humans Amebiasis Entamoebiasis Entamoeba histolytica Metronidazole RNA, Small Interfering Choline Kinase Isoquinolines
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