AIMC Topic: Thiazoles
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Inhibition of CDC27 O-GlcNAcylation coordinates the antitumor efficacy in multiple myeloma through the autophagy-lysosome pathway.
Acta pharmacologica Sinica
Feb 21, 2025
Multiple myeloma (MM) is a prevalent hematologic malignancy characterized by abnormal proliferation of cloned plasma cells. Given the aggressive nature and drug resistance of MM cells, identification of novel genes could provide valuable insights for...
A support vector machine-based approach to guide the selection of a pseudo-reference region for brain PET quantification.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Oct 13, 2024
A Support Vector Machine (SVM) based approach was developed to identify a pseudo-reference region for brain PET scans with the aim of reducing interscan and intersubject variability. By training a binary linear SVM classifier with PET datasets from t...
Translating amyloid PET of different radiotracers by a deep generative model for interchangeability.
NeuroImage
Feb 19, 2021
It is challenging to compare amyloid PET images obtained with different radiotracers. Here, we introduce a new approach to improve the interchangeability of amyloid PET acquired with different radiotracers through image-level translation. Deep genera...
Modeling autosomal dominant Alzheimer's disease with machine learning.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Jan 21, 2021
INTRODUCTION: Machine learning models were used to discover novel disease trajectories for autosomal dominant Alzheimer's disease.
Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease.
Science (New York, N.Y.)
Dec 10, 2020
Mapping the gene-regulatory networks dysregulated in human disease would allow the design of network-correcting therapies that treat the core disease mechanism. However, small molecules are traditionally screened for their effects on one to several o...
Aortic Valve Disease
Nitriles
Small Molecule Libraries
Induced Pluripotent Stem Cells
Receptor, Notch1
Haploinsufficiency
Gene Regulatory Networks
Mice
Disease Models, Animal
Mice, Inbred C57BL
Calcinosis
Aortic Valve Stenosis
Aortic Valve
Drug Evaluation, Preclinical
Thiazoles
Gene Expression Regulation
Machine Learning
Algorithms
Animals
Drug Discovery
RNA-Seq
Humans
Factor Xa inhibitors in clinical practice: Comparison of pharmacokinetic profiles.
Drug metabolism and pharmacokinetics
Oct 25, 2019
BACKGROUND: The anticoagulant actions of oral direct factor Xa (FXa) inhibitors can be inferred from their observed plasma concentrations; however, the steady-state pharmacokinetics (PK) of different FXa inhibitors have not been compared in clinicall...
Adaptive template generation for amyloid PET using a deep learning approach.
Human brain mapping
May 11, 2018
Accurate spatial normalization (SN) of amyloid positron emission tomography (PET) images for Alzheimer's disease assessment without coregistered anatomical magnetic resonance imaging (MRI) of the same individual is technically challenging. In this st...
Leaching and sorption of neonicotinoid insecticides and fungicides from seed coatings.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes
Dec 29, 2017
Seed coatings are a treatment used on a variety of crops to improve production and offer protection against pests and fungal outbreaks. The leaching of the active ingredients associated with the seed coatings and the sorption to soil was evaluated un...
Integrating DNA structure switch with branched hairpins for the detection of uracil-DNA glycosylase activity and inhibitor screening.
Talanta
Nov 22, 2017
The detection of uracil-DNA glycosylase (UDG) activity is pivotal for its biochemical studies and the development of drugs for UDG-related diseases. Here, we explored an integrated DNA structure switch for high sensitive detection of UDG activity. Th...
Accelerated Solvent Extraction of Insecticides from Rice Hulls, Rice Bran, and Polished Rice Grains.
Journal of AOAC International
Dec 23, 2016
Analysis of pesticide residues in irrigated rice grains is important for food security. In this study, we analyzed accelerated solvent extraction (ASE) conditions for the extraction of thiamethoxam and chlorantraniliprole insecticides from rice hulls...
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