Recurrent spontaneous abortion (RSA) represents a significant challenge in reproductive obstetrics, affecting approximately 5% of couples globally. Despite various treatments, the effectiveness of these interventions remains highly contentious. Emerg...
Wound healing is a dynamic process involving various cell types. Collecting samples from healing wounds and investigating their transcriptomics can provide deeper insights into the underlying processes. In recent years, several experiments have been ...
Neutrophils are the most abundant granulocyte population and have important functions such as defense against pathogens. However, they show significant Heterogeneity and play more complex roles in tumors. The theory of two-tiered differentiation of n...
Emerging evidence suggests that post-translational modifications (PTMs) contribute to osteosarcoma pathogenesis, yet their exact molecular roles require further elucidation. Using the AddModuleScore method, we classified tumor cells on the basis of P...
BACKGROUND AND AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease worldwide. Progression from simple metabolic dysfunction-associated steatotic liver (MASL) without necro-inflammation to...
Proceedings of the National Academy of Sciences of the United States of America
Oct 7, 2025
Protein secretion is an essential process of mammalian cells. In biomanufacturing, this process can be optimized to enhance production yields and biotherapeutic quality. While cell line engineering and bioprocess optimization have yielded high protei...
BACKGROUND: Primary Sjögren's syndrome (pSS) is an autoimmune and inflammatory disorder that may affect the lungs, leading to interstitial lung disease (ILD). However, the diagnosis of progression from pSS to ILD is frequently delayed due to unstanda...
Diabetic kidney disease (DKD) is a microvascular complication of diabetes that can progress to renal failure. Tert-butylhydroquinone (TBHQ) exhibits renal protective effects in type II diabetes, but its regulatory role on microvascular protection-rel...
Periodontitis, a prevalent inflammatory disease, leads to the progressive destruction of periodontal tissues and poses significant systemic health risks. Despite its widespread impact, the molecular mechanisms driving periodontitis remain poorly unde...
Clear cell renal cell carcinoma (ccRCC) is a highly heterogeneous tumor that lacks reliable biological markers for diagnosis and prognostic monitoring. Currently, the differentially expressed genes between paired adjacent normal tissues and ccRCC tum...
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